Abstract:
:Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion method, amides and heparin-like polymer are introduced to functionalize the core-shell beads. The beads are successfully prepared with obvious core-shell structure, adequate thermostability and porous shell. Clotting times and protein adsorption are investigated to inspect the hemocompatibility property of the beads. The adsorption of bilirubin is systematically investigated by evaluating the effects of contacting time, initial concentration and temperature on the adsorption, which exhibits improved bilirubin adsorption amount for the beads with amides contained cores or/and shells. It is worth believing that the amides and heparin-like polymer co-functionalized core-shell beads may be utilized in the field of hemoperfusion for bilirubin adsorption.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
He C,Li M,Zhang J,Yan B,Zhao W,Sun S,Zhao Cdoi
10.1002/mabi.202000153subject
Has Abstractpub_date
2020-08-01 00:00:00pages
e2000153issue
8eissn
1616-5187issn
1616-5195journal_volume
20pub_type
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