Abstract:
:Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl galactan contains differently methylated secondary hydroxyl groups. SEC and analytical ultracentrifugation showed a consistent decrease in the molecular weight after the consecutive reaction steps. Biological studies revealed that the methyl galactans are less active in complement fixation assays as compared with a 3-O-methyl galactan-enriched polysaccharide fraction isolated from Acanthus ebracteatus.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Koschella A,Inngjerdingen K,Paulsen BS,Morris GA,Harding SE,Heinze Tdoi
10.1002/mabi.200700120subject
Has Abstractpub_date
2008-01-09 00:00:00pages
96-105issue
1eissn
1616-5187issn
1616-5195journal_volume
8pub_type
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