Abstract:
:To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content. Correspondingly, the erosion rate increases with increasing PEG content, whereas it decreases with increasing specimen thickness. This indicates that the incorporation of poly(ethylene glycol) into traditional two-component polyanhydrides retains their surface erosion properties while making the erosion rate tunable. The new polyanhydrides hold potential for drug delivery applications.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Hou S,McCauley LK,Ma PXdoi
10.1002/mabi.200600256subject
Has Abstractpub_date
2007-05-10 00:00:00pages
620-8issue
5eissn
1616-5187issn
1616-5195journal_volume
7pub_type
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