Microparticles for drug delivery based on functional polycaprolactones with enhanced degradability: loading of hydrophilic and hydrophobic active compounds.

abstract：:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

journal_title：Macromolecular bioscience

authors： Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

更新日期：2007-11-12 00:00:00

abstract：:In the last decade, substantial research in the field of post-plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly-ε-caprolacto...

journal_title：Macromolecular bioscience

authors： Desmet T,Billiet T,Berneel E,Cornelissen R,Schaubroeck D,Schacht E,Dubruel P

更新日期：2010-12-08 00:00:00

abstract：:Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...

journal_title：Macromolecular bioscience

authors： Basinska T

更新日期：2005-12-15 00:00:00

abstract：:Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...

journal_title：Macromolecular bioscience

authors： Jia X,Kiick KL

更新日期：2009-02-11 00:00:00

abstract：:Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial c...

journal_title：Macromolecular bioscience

authors： Whittington CF,Yoder MC,Voytik-Harbin SL

更新日期：2013-09-01 00:00:00

abstract：:Although chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western world, it remains incurable with conventional chemotherapeutic agents. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an antitumor candidate in cancer therapy. This study examines the proapoptotic effects...

journal_title：Macromolecular bioscience

authors： Franiak-Pietryga I,Ostrowska K,Maciejewski H,Appelhans D,Misiewicz M,Ziemba B,Bednarek M,Bryszewska M,Borowiec M

更新日期：2017-05-01 00:00:00

abstract：:An antioxidant microgel with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities is reported. Using computational design and genetic engineering methods, the main catalytic components of GPx are fabricated onto the surface of ferritin. The resulting seleno-ferritin (Se-Fn) monomers can self-ass...

journal_title：Macromolecular bioscience

authors： Gao Y,Hou C,Zhou L,Zhang D,Zhang C,Miao L,Wang L,Dong Z,Luo Q,Liu J

更新日期：2013-06-01 00:00:00

abstract：:Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention...

journal_title：Macromolecular bioscience

authors： Kim M,Kim HS,Kim MA,Ryu H,Jeong HJ,Lee CM

更新日期：2017-05-01 00:00:00

abstract：:The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacit...

journal_title：Macromolecular bioscience

authors： Dong X,Lin L,Chen J,Guo Z,Tian H,Li Y,Wei Y,Chen X

更新日期：2013-04-01 00:00:00

abstract：:New nonfouling tubes are developed and their influence on the adhesion of neuroproteins is studied. The biomarkers are considered as single components (recombinant prion and Tau proteins) or in a solution of native and pathological forms. The samples are stored for 24 h at 4 °C in virgin and treated tubes layered with...

journal_title：Macromolecular bioscience

authors： Vrlinic T,Debarnot D,Legeay G,Coudreuse A,El Moualij B,Zorzi W,Perret-Liaudet A,Quadrio I,Mozetic M,Poncin-Epaillard F

更新日期：2012-10-01 00:00:00

abstract：:The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine and phenylalanine peptide synthons allow the assembly/disassembly to be adjusted in a physiologically relevant range of pH 5.3-6.0. Co...

journal_title：Macromolecular bioscience

authors： Ahlers P,Frisch H,Holm R,Spitzer D,Barz M,Besenius P

更新日期：2017-10-01 00:00:00

abstract：:Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, m...

journal_title：Macromolecular bioscience

authors： Ben-Shabat S,Kumar N,Domb AJ

更新日期：2006-12-08 00:00:00

abstract：:Surface structural characterisation of three different starch-based blends (with poly[ethylene-co-(vinyl alcohol)], cellulose acetate and polycaprolactone) was carried out. The results show that there is a difference between the bulk and the surface composition of all studied blends. Two different hypotheses were inve...

journal_title：Macromolecular bioscience

authors： Pashkuleva I,Azevedo HS,Reis RL

更新日期：2008-02-11 00:00:00

abstract：:Three different microbial wild-type strains are compared with respect to their potential as industrial scale polyhydroxyalkanoate (PHA) producers from the feed stock whey lactose. The halophilic archaeon Haloferax mediterranei as well as two eubacterial strains (Pseudomonas hydrogenovora and Hydrogenophaga pseudoflava...

journal_title：Macromolecular bioscience

authors： Koller M,Hesse P,Bona R,Kutschera C,Atlić A,Braunegg G

更新日期：2007-02-12 00:00:00

abstract：:A poly(o-methoxyaniline) (POMA)/DNA [weight fraction of DNA (W(DNA)) = 0.45] hybrid was prepared by mixing their solutions in sterilized double distilled water. The solution turned green upon aging for a longer time, and the doping of POMA by DNA was complete after about 15 d of aging. The doping was confirmed from th...

journal_title：Macromolecular bioscience

authors： Dawn A,Nandi AK

更新日期：2005-05-23 00:00:00

abstract：:Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...

journal_title：Macromolecular bioscience

authors： Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth T

更新日期：2012-06-01 00:00:00

abstract：:Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...

journal_title：Macromolecular bioscience

authors： Thielbeer F,Johansson EM,Chankeshwara SV,Bradley M

更新日期：2013-06-01 00:00:00

abstract：:This study describes the development and cell culture application of nanometer thick photocrosslinkable thermoresponsive polymer films prepared by physical adsorption. Two thermoresponsive polymers, poly(N-isopropylacrylamide (NIPAm)-co-acrylamidebenzophenone (AcBzPh)) and poly(NIPAm-co-AcBzPh-co-N-tertbutylacrylamide...

journal_title：Macromolecular bioscience

authors： Healy D,Nash ME,Gorelov A,Thompson K,Dockery P,Beloshapkin S,Rochev Y

更新日期：2017-02-01 00:00:00

abstract：:The role viscoelasticity in fibrotic disease progression is an emerging area of interest. Here, a fast-relaxing hydrogel system is exploited to investigate potential crosstalk between calcium signaling and mechanotransduction. Poly(ethylene glycol) (PEG) hydrogels containing boronate and triazole crosslinkers are synt...

journal_title：Macromolecular bioscience

authors： Ma H,Macdougall LJ,GonzalezRodriguez A,Schroeder ME,Batan D,Weiss RM,Anseth KS

更新日期：2020-12-01 00:00:00

abstract：:The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, inclu...

journal_title：Macromolecular bioscience

authors： Hsu SH,Tang CM,Chiu JJ,Liao TC,Lin CC,Iwata H

更新日期：2007-04-10 00:00:00

abstract：:A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide-co-polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature-induced precipitation method, to get multila...

journal_title：Macromolecular bioscience

authors： Dorati R,De Trizio A,Marconi S,Ferrara A,Auricchio F,Genta I,Modena T,Benazzo M,Benazzo A,Volpato G,Conti B

更新日期：2017-06-01 00:00:00

abstract：:Transparent, biodegradable, mechanically robust, and surface-patterned silk films were evaluated for the effect of surface morphology on human corneal fibroblast (hCF) cell proliferation, orientation, and ECM deposition and alignment. A series of dimensionally different surface groove patterns were prepared from optic...

journal_title：Macromolecular bioscience

authors： Gil ES,Park SH,Marchant J,Omenetto F,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:The biorecognition-based control of attachment/detachment of MCF-7 cancer cells from polymer-coated surfaces is demonstrated. A glass surface is coated with a thermoresponsive statistical copolymer of poly(N-isopropylacrylamide-co-acrylamide) [p(NIPAm-co-Am)], which is end-capped with the Gly-Arg-Gly-Asp-Ser (GRGDS) p...

journal_title：Macromolecular bioscience

authors： Brunato S,Mastrotto F,Bellato F,Garofalo M,Göddenhenrich T,Mantovani G,Alexander C,Gross S,Salmaso S,Caliceti P

更新日期：2020-11-04 00:00:00

abstract：:Back Cover: The authors have created polymers which release insulin using light. These materials utilize insulin itself as the primary monomer and therefore achieve a very high density (85% w/w insulin). This near perfect density makes them ideal as photoactivated depots of insulin. Further details can be found in the...

journal_title：Macromolecular bioscience

authors： Sarode BR,Jain PK,Friedman SH

更新日期：2016-08-01 00:00:00

abstract：:Amino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus-containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3 (ethyl glycinato)0.7 phosphazene] (PAG...

journal_title：Macromolecular bioscience

authors： Huang Z,Yang L,Hu X,Huang Y,Cai Q,Ao Y,Yang X

更新日期：2019-06-01 00:00:00

abstract：:In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross-linking agent for chitosan (CS). This biocompatible material cross-links and gels in minutes. The structure and morphology were characterized by various analyses. The results indicate that t...

journal_title：Macromolecular bioscience

authors： Yu H,Lu J,Xiao C

更新日期：2007-09-11 00:00:00

abstract：:A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...

journal_title：Macromolecular bioscience

authors： Soeda Y,Toshima K,Matsumura S

更新日期：2005-04-19 00:00:00

abstract：:The supramolecular self-assembly of macromonomers may serve as a first step to prepare well-defined, highly functionalized, hierarchically structured, conjugated polymers. Functional diacetylene macromonomers equipped with an oligopeptide segment designed to promote self-assembly into parallel beta-sheet type structur...

journal_title：Macromolecular bioscience

authors： Jahnke E,Millerioux AS,Severin N,Rabe JP,Frauenrath H

更新日期：2007-02-12 00:00:00

abstract：:A nanoscale biodegradable polymersome with pH-tuning on-off membrane is prepared via the self-assembly of poly(β-amino ester)-based amphiphilic copolymers. The pH-sensitive polymersome-like vesicle structure includes two layers that can encapsulate either hydrophobic or hydrophilic therapeutic drugs at physiological p...

journal_title：Macromolecular bioscience

authors： Jeong IK,Gao GH,Li Y,Kang SW,Lee DS

更新日期：2013-07-01 00:00:00

abstract：:Although recently a growing number of reports demonstrate that topography or geometry of the substrate also plays an important role in the fate of the stem cells, most of these studies are usually completed by a few distinct patterns such as simple lines, posts, etc. As a result, there is a lack of quantitative analys...

journal_title：Macromolecular bioscience

authors： Seo CH,Furukawa K,Suzuki Y,Kasagi N,Ichiki T,Ushida T

更新日期：2011-07-07 00:00:00