Abstract:
:Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential vehicle for sustained intravitreal drug delivery. The copolymer features a high molecular weight hyaluronic acid (HA) backbone and poly(glyceryl glycerol) (PGG) side chains attached via hydrolysable ester linkers. PGG, a polyether with 1,2-diol groups in every repeating unit available for conjugation, serves as a detachable carrier. The influence of synthesis conditions and incubation in physiological media on the molecular weight of HA is studied. The cleavage of the PGG grafts from the HA backbone is quantified and polymer-from-polymer release kinetics are determined. The biocompatibility of the materials is tested in different cell cultures.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Borke T,Najberg M,Ilina P,Bhattacharya M,Urtti A,Tenhu H,Hietala Sdoi
10.1002/mabi.201700200subject
Has Abstractpub_date
2018-01-01 00:00:00issue
1eissn
1616-5187issn
1616-5195journal_volume
18pub_type
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