Macromol. Biosci. 8/2016.

abstract：:Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and respons...

journal_title：Macromolecular bioscience

authors： Aksoy N,Akinci OF

更新日期：2004-05-17 00:00:00

abstract：:Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly im...

journal_title：Macromolecular bioscience

authors： Sherrell PC,Cieślar-Pobuda A,Ejneby MS,Sammalisto L,Gelmi A,de Muinck E,Brask J,Łos MJ,Rafat M

更新日期：2017-07-01 00:00:00

abstract：:The present study investigates the effect of galactosylated gelatin on encapsulated HepG2 cells. Methacrylamide modified gelatin is evaluated and compared with its galactosylated counterpart with respect to effects on viability, morphological characteristics, proliferation, and the expression of hepatocyte specific ma...

journal_title：Macromolecular bioscience

authors： Gevaert E,Billiet T,Declercq H,Dubruel P,Cornelissen R

更新日期：2014-03-01 00:00:00

abstract：:The major route to convert lactic acid to high-molecular-weight polymers is ring-opening polymerization of lactide. We have investigated alternative synthesis routes based on oligomerization and chain linking to produce high-molecular-weight thermoplastic degradable polymers cost-effectively. Chain linking also offers...

journal_title：Macromolecular bioscience

authors： Seppälä JV,Helminen AO,Korhonen H

更新日期：2004-03-15 00:00:00

abstract：:Metastasis is a pathogenic spread of cancer cells from the primary site to surrounding tissues and distant organs, making it one of the primary challenges for effective cancer treatment and the major cause of cancer mortality. Heparin-based biomaterials exhibit significant inhibition of cancer cell metastasis. In this...

journal_title：Macromolecular bioscience

authors： Andrgie AT,Mekuria SL,Addisu KD,Hailemeskel BZ,Hsu WH,Tsai HC,Lai JY

更新日期：2019-05-01 00:00:00

abstract：:Uniform stereo-complex microparticles ranging from nanometer to micrometer size are prepared by using stereo multiblock co-poly(rac-lactide)s (smb-PLAs) with different stereo-regularity. At comparable molecular weights, as the smb-PLA stereo-regularity decreases from 88% to 76%, the crystallinity of the microparticles...

journal_title：Macromolecular bioscience

authors： Hu J,Tang Z,Qiu X,Han Y,Du Q,Chen X,Jing X

更新日期：2005-12-15 00:00:00

abstract：:5,6-Bis(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside the cells. In spite of the promising potential as an anticancer agent, hydrophobicity of SC...

journal_title：Macromolecular bioscience

authors： John F,George J,Vartak SV,Srivastava M,Hassan PA,Aswal VK,Karki SS,Raghavan SC

更新日期：2015-04-01 00:00:00

abstract：:Two chondrogenic factors, Dex and TGF-beta1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-beta1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were s...

journal_title：Macromolecular bioscience

authors： Park K,Cho KJ,Kim JJ,Kim IH,Han DK

更新日期：2009-03-10 00:00:00

abstract：:Emphasizing the role of hydrogel stiffness and cellular differentiation, this study develops collagen and elastin-like polypeptide (ELP)-based bone regenerative hydrogels loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) and doxycycline with mechanical properties suitable for osteogenesis. The drug-...

journal_title：Macromolecular bioscience

authors： Pal P,Nguyen QC,Benton AH,Marquart ME,Janorkar AV

更新日期：2019-09-01 00:00:00

abstract：:Amylose-fatty acid inclusion complexes can be easily prepared by simple mixing in hot aqueous solutions. Above a critical chain length (C6) of the fatty acid insoluble complexes between amylose and each fatty acid (C8, C10, C12, C14, C16) were precipitated from the solution, and characterized by FT-IR, XRD, DSC, and S...

journal_title：Macromolecular bioscience

authors： Cao Z,Woortman AJ,Rudolf P,Loos K

更新日期：2015-05-01 00:00:00

abstract：:We report the self-assembly of a series of amphiphilic diblock copolymers comprising a biocompatible, hydrophilic block, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and a pH-sensitive block, poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), into a dispersion of colloidally stable, nanometer-sized polymers...

journal_title：Macromolecular bioscience

authors： Lomas H,Du J,Canton I,Madsen J,Warren N,Armes SP,Lewis AL,Battaglia G

更新日期：2010-05-14 00:00:00

abstract：:The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacit...

journal_title：Macromolecular bioscience

authors： Dong X,Lin L,Chen J,Guo Z,Tian H,Li Y,Wei Y,Chen X

更新日期：2013-04-01 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...

journal_title：Macromolecular bioscience

authors： Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MR

更新日期：2009-09-09 00:00:00

abstract：:To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with inc...

journal_title：Macromolecular bioscience

authors： Hou S,McCauley LK,Ma PX

更新日期：2007-05-10 00:00:00

abstract：:This work focuses on the development of ultrasound contrast vesicles for ultrasound-mediated enhanced transfection of nucleic acids in the cancer cells and projects its application as a tool for diagnostic imaging. The ultrasound contrast vesicles are stable, anionic, nanoscaled vesicles with ultrasound contrast equiv...

journal_title：Macromolecular bioscience

authors： Shah H,Tariq I,Engelhardt K,Bakowsky U,Pinnapireddy SR

更新日期：2020-12-01 00:00:00

abstract：:Current methods of tissue fixation rely on mechanical-related technologies developed from the clothing and carpentry industries. Herein, a novel bioadhesive method that allows tuneable adhesion and is also applicable to biodegradable polyester substrates is described. Diazirine is the key functional group that allows ...

journal_title：Macromolecular bioscience

authors： Mogal V,Papper V,Chaurasia A,Feng G,Marks R,Steele T

更新日期：2014-04-01 00:00:00

abstract：:Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...

journal_title：Macromolecular bioscience

authors： Nijhuis AW,Leeuwenburgh SC,Jansen JA

更新日期：2010-11-10 00:00:00

abstract：:Pulmonary air leaks are medical complications of thoracic surgery for which fibrin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their ...

journal_title：Macromolecular bioscience

authors： Mizuta R,Taguchi T

更新日期：2017-04-01 00:00:00

abstract：:Integration of electrogenic microorganisms remains a challenge in biofuel cell technology. Here, synthetic biocomposites ("artificial biofilms") are proposed. Bacteria (Shewanella oneidensis) are embedded in a hydrogel matrix (poly(vinyl alcohol)) via wet- and electrospinning, creating fibers and nonwoven gauzes. The ...

journal_title：Macromolecular bioscience

authors： Kaiser P,Reich S,Leykam D,Willert-Porada M,Greiner A,Freitag R

更新日期：2017-07-01 00:00:00

abstract：:Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...

journal_title：Macromolecular bioscience

authors： Awada HK,Johnson NR,Wang Y

更新日期：2014-05-01 00:00:00

abstract：:Blend films of silk fibroin and carboxymethyl chitin were prepared by solution casting using water as a cosolvent. The blend films were subjected to post-treatment with an aqueous methanol solution to induce beta-sheet formation of silk fibroin. The miscibility of the blend films both before and after methanol treatme...

journal_title：Macromolecular bioscience

authors： Wongpanit P,Tabata Y,Rujiravanit R

更新日期：2007-12-06 00:00:00

abstract：:Polycations, mimicking activity of antibacterial peptides, belong to an important class of molecules investigated as a support or as an alternative to antibiotics. In this work, studies of modified linear amphiphilic statistical polymethyloxazoline (PMOX) and polyethyleneimine copolymers (PMOX_PEI) series are presente...

journal_title：Macromolecular bioscience

authors： Kozon D,Mierzejewska J,Kobiela T,Grochowska A,Dudnyk K,Głogowska A,Sobiepanek A,Kuźmińska A,Ciach T,Augustynowicz-Kopeć E,Jańczewski D

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study is to design a novel two-component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin-based dermal scaffold more robust for the treatment of the clinically challenging pres...

journal_title：Macromolecular bioscience

authors： Sharma V,Kohli N,Moulding D,Afolabi H,Hook L,Mason C,García-Gareta E

更新日期：2017-11-01 00:00:00

abstract：:Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trim...

journal_title：Macromolecular bioscience

authors： Jansen J,Mihov G,Feijen J,Grijpma DW

更新日期：2012-05-01 00:00:00

abstract：:Uniform chitosan microspheres have been fabricated and weakly crosslinked for potential applications in colon-specific drug delivery. The effects of microsphere size, crosslinking density and electrostatic interactions between the drug and chitosan on drug release were studied, employing model drugs of different acidi...

journal_title：Macromolecular bioscience

authors： Choy YB,Cheng F,Choi H,Kim KK

更新日期：2008-12-08 00:00:00

abstract：:We report on a novel series of biomimetic polymers exhibiting interfacial properties similar to the extracellular matrix. A series of well-defined surfactant polymers were synthesized by simultaneously incorporating arginine-glycine-aspartic acid (RGD) peptide, dextran oligosaccharide, and hexyl ligands with controlle...

journal_title：Macromolecular bioscience

authors： Anderson EH,Ruegsegger MA,Murugesan G,Kottke-Marchant K,Marchant RE

更新日期：2004-08-09 00:00:00

abstract：:Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, a family of β-galactoside-binding proteins, are known to play ...

journal_title：Macromolecular bioscience

authors： Freichel T,Heine V,Laaf D,Mackintosh EE,Sarafova S,Elling L,Snyder NL,Hartmann L

更新日期：2020-09-01 00:00:00

abstract：:Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength ...

journal_title：Macromolecular bioscience

authors： Rajkhowa R,Gil ES,Kluge J,Numata K,Wang L,Wang X,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug-resistant Gram-negative "superbugs," especially the problematic Pseudomonas aeruginosa. In this work, the incorporation of colistin, a potent lipopeptide into a self-healable hydrogel (via dynamic imine bond form...

journal_title：Macromolecular bioscience

authors： Zhu C,Zhao J,Kempe K,Wilson P,Wang J,Velkov T,Li J,Davis TP,Whittaker MR,Haddleton DM

更新日期：2017-02-01 00:00:00