Amphiphilic Polymethyloxazoline-Polyethyleneimine Copolymers: Interaction with Lipid Bilayer and Antibacterial Properties.

Abstract:

:Polycations, mimicking activity of antibacterial peptides, belong to an important class of molecules investigated as a support or as an alternative to antibiotics. In this work, studies of modified linear amphiphilic statistical polymethyloxazoline (PMOX) and polyethyleneimine copolymers (PMOX_PEI) series are presented. Variation of PEI content in the structure results in controllable changes of polymeric aggregates zeta potential. The structure with the highest positive charge shows the best antimicrobial activity, well visible in tests against model Gram-positive and Gram-negative bacteria, fungi, and mycobacterium strains. The polymer toxicity is evaluated with MTT and hemolysis assay as a reference. Quartz crystal microbalance (QCM-D) is used to investigate interaction between polycations and a model lipid membrane. Polymer activity correlates well with molecular structure, showing that amphiphilic component is altering polymer behavior in contact with the lipid bilayer.

journal_name

Macromol Biosci

authors

Kozon D,Mierzejewska J,Kobiela T,Grochowska A,Dudnyk K,Głogowska A,Sobiepanek A,Kuźmińska A,Ciach T,Augustynowicz-Kopeć E,Jańczewski D

doi

10.1002/mabi.201900254

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

e1900254

issue

12

eissn

1616-5187

issn

1616-5195

journal_volume

19

pub_type

杂志文章
  • Temperature-sensitive polyamidoamine dendrimer/poly(N-isopropylacrylamide) hydrogels with improved responsive properties.

    abstract::Novel temperature-sensitive poly(N-isopropylacrylamide)/amine-terminated polyamidoamine dendrimer G6-NH2 hydrogels with fast responsive properties were synthesized by forming semi-interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temp...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200400003

    authors: Zhang JT,Huang SW,Zhuo RX

    更新日期:2004-06-25 00:00:00

  • Biological natural retting for determining the hierarchical structuration of banana fibers.

    abstract::Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200400041

    authors: Gañán P,Zuluaga R,Velez JM,Mondragon I

    更新日期:2004-10-20 00:00:00

  • Evidences of the Effect of GO and rGO in PCL Membranes on the Differentiation and Maturation of Human Neural Progenitor Cells.

    abstract::The effect of doping graphene oxide (GO) and reduced graphene oxide (rGO) into poly(ε-caprolactone) (PCL) membranes prepared by solvent induced phase separation is evaluated in terms of nanomaterial distribution and compatibility with neural stem cell growth and functional differentiation. Raman spectra analyses demon...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201800195

    authors: Sánchez-González S,Diban N,Bianchi F,Ye H,Urtiaga A

    更新日期:2018-11-01 00:00:00

  • Long-Term Stable Poly(acrylamide) Brush Modified Transparent Microwells for Cell Attachment Studies in 3D.

    abstract::The fabrication of 3D cell microenvironments exploiting versatile, long-term stable passivating poly(acryl amide) brushes in a microwell format and the study of the behavior of fibroblast and pancreatic tumor cells in wells of systematically varied shape and size is reported. The microwells, which are obtained by comb...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600451

    authors: Lilge I,Jiang S,Schönherr H

    更新日期:2017-05-01 00:00:00

  • Quantifying Thermoswitchable Carbohydrate-Mediated Interactions via Soft Colloidal Probe Adhesion Studies.

    abstract::Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.202000186

    authors: Strzelczyk AK,Paul TJ,Schmidt S

    更新日期:2020-10-01 00:00:00

  • Wet-chemical deposition of functional coatings for bone implantology.

    abstract::Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.201000142

    authors: Nijhuis AW,Leeuwenburgh SC,Jansen JA

    更新日期:2010-11-10 00:00:00

  • Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications.

    abstract::Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, ce...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201900090

    authors: Dera R,Diliën H,Billen B,Gagliardi M,Rahimi N,Van Den Akker NMS,Molin DGM,Grandfils C,Adriaensens P,Guedens W,Cleij TJ

    更新日期:2019-07-01 00:00:00

  • Electrospun antibacterial chitosan-based fibers.

    abstract::Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.201300058

    authors: Ignatova M,Manolova N,Rashkov I

    更新日期:2013-07-01 00:00:00

  • Microspheres made of poly(epsilon-caprolactone)-based amphiphilic copolymers: potential in sustained delivery of proteins.

    abstract::Microspheres of amphiphilic multi-block poly(ester-ether)s (PEE)s and poly(ester-ether-amide)s (PEEA)s based on poly(epsilon-caprolactone) (PCL) were investigated as delivery systems for proteins. The interest was mainly focused on the effect of their molecular structure and composition on the overall properties of th...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200500108

    authors: Quaglia F,Ostacolo L,Nese G,De Rosa G,La Rotonda MI,Palumbo R,Maglio G

    更新日期:2005-10-20 00:00:00

  • A Novel Small-Caliber Bacterial Cellulose Vascular Prosthesis: Production, Characterization, and Preliminary In Vivo Testing.

    abstract::Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose (BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall p...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201500251

    authors: Leitão AF,Faria MA,Faustino AM,Moreira R,Mela P,Loureiro L,Silva I,Gama M

    更新日期:2016-01-01 00:00:00

  • Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers.

    abstract::Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many n...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700095

    authors: Jacobsen MM,Tokareva OS,Ebrahimi D,Huang W,Ling S,Dinjaski N,Li D,Simon M,Staii C,Buehler MJ,Kaplan DL,Wong JY

    更新日期:2017-09-01 00:00:00

  • Mitogenic activity of sulfated chitosan and cellulose derivatives is related to protection of FGF-2 from proteolytic cleavage.

    abstract::Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201100518

    authors: Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth T

    更新日期:2012-06-01 00:00:00

  • Plasmid DNA microgels for a therapeutical strategy combining the delivery of genes and anticancer drugs.

    abstract::Plasmid DNA (pDNA) is encapsulated into biocompatible microgels by an inverse microemulsion polymerization method. Plasmid DNA and doxorubicin are successfully released from pDNA microgels and their release profiles are characterized by appropriate release models. The co-delivery of genes and drugs from the microgels ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200096

    authors: Costa D,Valente AJ,Miguel MG,Queiroz J

    更新日期:2012-09-01 00:00:00

  • Sequence-Defined Heteromultivalent Precision Glycomacromolecules Bearing Sulfonated/Sulfated Nonglycosidic Moieties Preferentially Bind Galectin-3 and Delay Wound Healing of a Galectin-3 Positive Tumor Cell Line in an In Vitro Wound Scratch Assay.

    abstract::Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, a family of β-galactoside-binding proteins, are known to play ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.202000163

    authors: Freichel T,Heine V,Laaf D,Mackintosh EE,Sarafova S,Elling L,Snyder NL,Hartmann L

    更新日期:2020-09-01 00:00:00

  • Physicochemical Characterization of the Shell Composition of PBCA-Based Polymeric Microbubbles.

    abstract::Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. In recent years, MB have also attracted interest as drug delivery systems. Soft-shelled lipidic MB tend to be more advantageous for US imaging, while hard-shelled polymeric MB appear to be more suitable for drug delivery purposes beca...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700002

    authors: Appold L,Shi Y,Rütten S,Kühne A,Pich A,Kiessling F,Lammers T

    更新日期:2017-10-01 00:00:00

  • Reducible Polyethylenimine Nanoparticles for Efficient siRNA Delivery in Corneal Neovascularization Therapy.

    abstract::The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducibl...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600051

    authors: Han H,Son S,Son S,Kim N,Yhee JY,Lee JH,Choi JS,Joo CK,Lee H,Lee D,Kim WJ,Kim SH,Kwon IC,Kim H,Kim K

    更新日期:2016-11-01 00:00:00

  • Extracellular matrix-like surfactant polymers containing arginine-glycine-aspartic acid (RGD) peptides.

    abstract::We report on a novel series of biomimetic polymers exhibiting interfacial properties similar to the extracellular matrix. A series of well-defined surfactant polymers were synthesized by simultaneously incorporating arginine-glycine-aspartic acid (RGD) peptide, dextran oligosaccharide, and hexyl ligands with controlle...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200300125

    authors: Anderson EH,Ruegsegger MA,Murugesan G,Kottke-Marchant K,Marchant RE

    更新日期:2004-08-09 00:00:00

  • Fabrication and Application of Photocrosslinked, Nanometer-Scale, Physically Adsorbed Films for Tissue Culture Regeneration.

    abstract::This study describes the development and cell culture application of nanometer thick photocrosslinkable thermoresponsive polymer films prepared by physical adsorption. Two thermoresponsive polymers, poly(N-isopropylacrylamide (NIPAm)-co-acrylamidebenzophenone (AcBzPh)) and poly(NIPAm-co-AcBzPh-co-N-tertbutylacrylamide...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600175

    authors: Healy D,Nash ME,Gorelov A,Thompson K,Dockery P,Beloshapkin S,Rochev Y

    更新日期:2017-02-01 00:00:00

  • In Vivo Imaging of Glycol Chitosan-Based Nanogel Biodistribution.

    abstract::The preclinical development of nanomedicines raises several challenges and requires a comprehensive characterization. Among them is the evaluation of the biodistribution following systemic administration. In previous work, the biocompatibility and in vitro targeting ability of a glycol chitosan (GC) based nanogel have...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201500267

    authors: Pereira P,Correia A,Gama FM

    更新日期:2016-03-01 00:00:00

  • Hybrid multicomponent hydrogels for tissue engineering.

    abstract::Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.200800284

    authors: Jia X,Kiick KL

    更新日期:2009-02-11 00:00:00

  • Novel polymeric vesicles with pH-induced deformation character for advanced drug delivery.

    abstract::pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lip...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000333

    authors: Zheng C,Yao X,Qiu L

    更新日期:2011-03-10 00:00:00

  • Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents.

    abstract::Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600105

    authors: Navarro L,Mogosanu DE,de Jong T,Bakker AD,Schaubroeck D,Luna J,Rintoul I,Vanfleteren J,Dubruel P

    更新日期:2016-11-01 00:00:00

  • Development and Characterization of Ultrasound Activated Lipopolyplexes for Enhanced Transfection by Low Frequency Ultrasound in In Vitro Tumor Model.

    abstract::This work focuses on the development of ultrasound contrast vesicles for ultrasound-mediated enhanced transfection of nucleic acids in the cancer cells and projects its application as a tool for diagnostic imaging. The ultrasound contrast vesicles are stable, anionic, nanoscaled vesicles with ultrasound contrast equiv...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.202000173

    authors: Shah H,Tariq I,Engelhardt K,Bakowsky U,Pinnapireddy SR

    更新日期:2020-12-01 00:00:00

  • New insight into biodegradation of polylactide (PLA)/clay nanocomposites using molecular ecological techniques.

    abstract::Novel molecular ecological techniques were used to study changes in microbial community structure and population during degradation of polylactide (PLA)/organically modified layered silicates (OMLS) nanocomposites. Cloned gene sequences belonging to members of the phyla Actinobacteria and Ascomycota comprized the most...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200800276

    authors: Sangwan P,Way C,Wu DY

    更新日期:2009-07-07 00:00:00

  • Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils.

    abstract::Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutro...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700214

    authors: Sacco P,Decleva E,Tentor F,Menegazzi R,Borgogna M,Paoletti S,Kristiansen KA,Vårum KM,Marsich E

    更新日期:2017-11-01 00:00:00

  • Macromol. Biosci. 8/2016.

    abstract::Back Cover: The authors have created polymers which release insulin using light. These materials utilize insulin itself as the primary monomer and therefore achieve a very high density (85% w/w insulin). This near perfect density makes them ideal as photoactivated depots of insulin. Further details can be found in the...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201670032

    authors: Sarode BR,Jain PK,Friedman SH

    更新日期:2016-08-01 00:00:00

  • Solvent-responsive behavior of inclusion complexes between amylose and polytetrahydrofuran.

    abstract::Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201300174

    authors: Rachmawati R,Woortman AJ,Loos K

    更新日期:2014-01-01 00:00:00

  • Direct adhesion of endothelial cells to bioinspired poly(dopamine) coating through endogenous fibronectin and integrin α5 β1.

    abstract::Mussel-inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In this study, the initial adhesive behavior of human umbilical vein endothelial cells (HUVECs) is evaluated on a PDA coating under serum-free conditions. It is fou...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200390

    authors: Wang JL,Ren KF,Chang H,Jia F,Li BC,Ji Y,Ji J

    更新日期:2013-04-01 00:00:00

  • Enzymatic transformation of bacterial polyhydroxyalkanoates into repolymerizable oligomers directed towards chemical recycling.

    abstract::The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200500030

    authors: Kaihara S,Osanai Y,Nishikawa K,Toshima K,Doi Y,Matsumura S

    更新日期:2005-07-14 00:00:00

  • Non-Anticoagulant Heparin Prodrug Loaded Biodegradable and Injectable Thermoresponsive Hydrogels for Enhanced Anti-Metastasis Therapy.

    abstract::Metastasis is a pathogenic spread of cancer cells from the primary site to surrounding tissues and distant organs, making it one of the primary challenges for effective cancer treatment and the major cause of cancer mortality. Heparin-based biomaterials exhibit significant inhibition of cancer cell metastasis. In this...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201800409

    authors: Andrgie AT,Mekuria SL,Addisu KD,Hailemeskel BZ,Hsu WH,Tsai HC,Lai JY

    更新日期:2019-05-01 00:00:00