Abstract:
:Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrating modular and heterogeneous building blocks into well-defined, multifunctional hydrogel composites. The individual building blocks can be chemically, morphologically, and functionally diverse, and the hybridization can occur at molecular level or microscopic scale. The modular nature of the designs, combined with the potential synergistic effects of the hybrid systems, has resulted in novel hydrogel matrices with robust structure and defined functions.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Jia X,Kiick KLdoi
10.1002/mabi.200800284subject
Has Abstractpub_date
2009-02-11 00:00:00pages
140-56issue
2eissn
1616-5187issn
1616-5195journal_volume
9pub_type
杂志文章,评审abstract::A novel cell-supporting scaffold, Tetronic-oligolactide-heparin (TLH) hydrogel, was prepared by coupling heparin to polymerized Tetronic-oligolactide for use in improving tissue regeneration. Aqueous TLH solutions showed thermosensitive behavior, demonstrating potential for use as injectable hydrogels. The content and...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800098
更新日期:2008-12-08 00:00:00
abstract::Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800019
更新日期:2018-07-01 00:00:00
abstract::"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400488
更新日期:2015-05-01 00:00:00
abstract::In the last decade, substantial research in the field of post-plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly-ε-caprolacto...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000147
更新日期:2010-12-08 00:00:00
abstract::The antiviral effects of the cationic acrylate polymer E100 on a panel of lipid-enveloped viruses and the interactions involved are studied. The treatment of several common viruses with E100 induced a dose-dependent inhibition of the infectivity of viruses below the detection limit of the assays employed. Similarly, t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700102
更新日期:2007-09-11 00:00:00
abstract::A new anhydroribotrisaccharide monomer, A2B3LR (1), was synthesized and ROP was carried out to elucidate the polymerizability and to obtain oligosaccharide-branched polysaccharides with defined structures. The new trisaccharide monomer was found to be polymerized readily with BF(3) . OEt(2) as a catalyst at -40 degree...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800316
更新日期:2009-07-07 00:00:00
abstract::The synthesis of a new glycomonomer based on mannose, prepared via CuAAC, is reported. The resulting 1,2,3-triazole linkage between mannose and the polymer backbone ensures the formation of highly stable glycopolymers, which will not undergo hydrolysis. The monomer 2'-(4-vinyl-[1,2,3]-triazol-1-yl)ethyl-O-alpha-D-mann...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900199
更新日期:2010-02-11 00:00:00
abstract::Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300055
更新日期:2004-04-19 00:00:00
abstract::Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300174
更新日期:2014-01-01 00:00:00
abstract::Bioinks play a key role in determining the capability of the biofabricatoin processes and the resolution of the printed constructs. Excellent biocompatibility, tunable physical properties, and ease of chemical or biological modifications of gelatin methacryloyl (GelMA) have made it an attractive choice as bioinks for ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000317
更新日期:2021-01-01 00:00:00
abstract::Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000153
更新日期:2020-08-01 00:00:00
abstract::Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800106
更新日期:2009-01-09 00:00:00
abstract::Although recently a growing number of reports demonstrate that topography or geometry of the substrate also plays an important role in the fate of the stem cells, most of these studies are usually completed by a few distinct patterns such as simple lines, posts, etc. As a result, there is a lack of quantitative analys...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000477
更新日期:2011-07-07 00:00:00
abstract::Multicomponent systems for self-assembled molecular gels provide huge opportunities to generate collective or new functions that are not inherent in individual single-component gels. However, gelation tends to require careful and complicated procedures, because, among a myriad of kinetically trapped structures related...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000187
更新日期:2020-09-01 00:00:00
abstract::Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200455
更新日期:2013-06-01 00:00:00
abstract::Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400152
更新日期:2014-10-01 00:00:00
abstract::Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201800240
更新日期:2018-12-01 00:00:00
abstract::Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300486
更新日期:2014-05-01 00:00:00
abstract::Bleeding complications usually cause significant morbidity and mortality in civilian and military populations. In clinical application, hemostatic sponges, gauzes, hydrogel, and bandages are widely used as the traditional effective hemostatic products for hemorrhage. However, the traditional hemostatic devices or agen...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201900370
更新日期:2020-04-01 00:00:00
abstract::A generally applicable strategy to obtain mechanically robust hydrogels for the incorporation and containment of functional reporter bacteria for the microarray and microparticle-based detection and signaling of N-acyl homoserine lactone autoinducers (3OC12 HSL) at relevant concentrations is reported. For reinforcing ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700176
更新日期:2017-11-01 00:00:00
abstract::3D hydrogels better replicate in vivo conditions, and yield different results from 2D substrates. However, imaging interactions between cells and the hydrogel microenvironment is challenging because of light diffraction and poor focal depth. Here, cryosectioning and vibrating microtomy methods and fixation protocols a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600478
更新日期:2017-06-01 00:00:00
abstract::In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scann...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800271
更新日期:2019-02-01 00:00:00
abstract::BSA adsorption onto negatively and positively charged polystyrene nanoparticles was investigated. The nanoparticles were characterized in terms of particle size, zeta potential, surface group density, and morphology. The adsorption behavior of BSA on the particle surface, as a function of pH and overall charge of the ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000395
更新日期:2011-05-12 00:00:00
abstract::Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Micro...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200317
更新日期:2013-03-01 00:00:00
abstract::The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-solubl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500131
更新日期:2015-08-01 00:00:00
abstract::Multivalent carbohydrate-lectin interactions play a crucial role in bacterial infection. Biomimicry of multivalent glycosystems represents a major strategy in the repression of bacterial growth. In this study, a new kind of glycopeptide (Naphthyl-Phe-Phe-Ser-Tyr, NMY) scaffold with mannose modification is designed and...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900124
更新日期:2019-09-01 00:00:00
abstract::In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: I...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600505
更新日期:2017-10-01 00:00:00
abstract::The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000364
更新日期:2021-01-12 00:00:00
abstract::Novel water-insoluble, and reduction-responsive nonwoven scaffolds were fabricated from gamma-PGA and tested in cell culture. An electrospinning method was developed to produce scaffolds of fibers with diameters of 0.05-0.5 microm. Crosslinking of the fibers with cystamine in the presence of EDC resulted in water-inso...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800334
更新日期:2009-06-11 00:00:00
abstract::Polylaminin (polyLM) is a polymerized form of the extracellular matrix protein laminin obtained upon pH acidification. Here microscopy and spectroscopic tools are used to study the cell compatibility and the structural stability of polyLM, aiming at establishing its robustness as a biopolymer for therapeutic use. Poly...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100125
更新日期:2012-01-01 00:00:00