Abstract:
:The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-soluble core-shell smart nanocarriers show low toxicity in terms of cell viability and absence of glutathione depletion, two of the major side effect limitations of current vectors. The materials are also found to act as good transfection agents, through a mechanism involving an endosomal pathway, being able to reduce 100-fold the IC50 of paclitaxel.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Restani RB,Conde J,Pires RF,Martins P,Fernandes AR,Baptista PV,Bonifácio VD,Aguiar-Ricardo Adoi
10.1002/mabi.201500131subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1045-51issue
8eissn
1616-5187issn
1616-5195journal_volume
15pub_type
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