Abstract:
:The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is successfully loaded inside the core and embedded between polymer layers. MS is used to quantify the loading efficiency by comparing post-loading and core-loading methods, since both coated templates and hollow shells are used as carriers. CLSM confirms dissolution of the pre-formed multilayer upon enzymatic degradation as the method of release, and migration assays demonstrate a higher inhibition efficiency of TGF-beta in tailored biodegradable capsules compared to free LY administration.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Baldassarre F,Vergaro V,Scarlino F,De Santis F,Lucarelli G,Torre AD,Ciccarella G,Rinaldi R,Giannelli G,Leporatti Sdoi
10.1002/mabi.201100457subject
Has Abstractpub_date
2012-05-01 00:00:00pages
656-65issue
5eissn
1616-5187issn
1616-5195journal_volume
12pub_type
杂志文章abstract::In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scann...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800271
更新日期:2019-02-01 00:00:00
abstract::Amylose-fatty acid inclusion complexes can be easily prepared by simple mixing in hot aqueous solutions. Above a critical chain length (C6) of the fatty acid insoluble complexes between amylose and each fatty acid (C8, C10, C12, C14, C16) were precipitated from the solution, and characterized by FT-IR, XRD, DSC, and S...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400464
更新日期:2015-05-01 00:00:00
abstract::Injectable hydrogels are extensively used in drug delivery and tissue engineering to administer drugs, genes, growth factors and live cells. We report a method to produce tough, in-situ thermogelling, non-toxic, injectable hydrogels made of chitosan and hyaluronic acid co-crosslinked with β-glycerophophate and genipin...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400406
更新日期:2015-04-01 00:00:00
abstract::Redox-responsive micelles are versatile nanoplatforms for on-demand drug delivery, but the in situ evaluation of drug release is challenging. Fluorescence resonance energy transfer (FRET) technique shows potential for addressing this, while the aggregation-caused quenching effect limits the assay sensitivity. The aim ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700339
更新日期:2018-03-01 00:00:00
abstract::In the last decade, substantial research in the field of post-plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly-ε-caprolacto...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000147
更新日期:2010-12-08 00:00:00
abstract::Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200800284
更新日期:2009-02-11 00:00:00
abstract::Mussel-inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In this study, the initial adhesive behavior of human umbilical vein endothelial cells (HUVECs) is evaluated on a PDA coating under serum-free conditions. It is fou...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200390
更新日期:2013-04-01 00:00:00
abstract::A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide-co-polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature-induced precipitation method, to get multila...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600426
更新日期:2017-06-01 00:00:00
abstract::The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducibl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600051
更新日期:2016-11-01 00:00:00
abstract::Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400121
更新日期:2005-01-14 00:00:00
abstract::Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700120
更新日期:2008-01-09 00:00:00
abstract::Conducting polymers (CPs) is one of intelligent biomaterials with the specific properties of reversible redox states, which have a significant effects on the cell behaviors and nerve tissue regeneration. However, the effects of CPs with different electrical conductivity on the behaviors of nerve cells are rarely repor...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900147
更新日期:2019-10-01 00:00:00
abstract::Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300486
更新日期:2014-05-01 00:00:00
abstract::5,6-Bis(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside the cells. In spite of the promising potential as an anticancer agent, hydrophobicity of SC...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400480
更新日期:2015-04-01 00:00:00
abstract::In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross-linking agent for chitosan (CS). This biocompatible material cross-links and gels in minutes. The structure and morphology were characterized by various analyses. The results indicate that t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700035
更新日期:2007-09-11 00:00:00
abstract::In this report, we developed a simple and green process of simultaneous formation of doxorubicin-BSA-dextran nanoparticles in aqueous solution and high-effective encapsulation of doxorubicin. In the presence of BSA-dextran conjugates, which were produced by Maillard reaction, a binding of doxorubicin with BSA can supp...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000125
更新日期:2010-10-08 00:00:00
abstract::A ternary complex comprising plasmid DNA, lipopolysaccharide-binding peptide (LBP), and deoxycholic acid-conjugated polyethylenimine (PEI-DA) is prepared for combinational therapy of acute lung injury (ALI). The LBP is designed as an anti-inflammatory peptide based on the lipopolysaccharide (LPS)-binding domain of HMG...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600490
更新日期:2017-08-01 00:00:00
abstract::Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100518
更新日期:2012-06-01 00:00:00
abstract::We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800359
更新日期:2009-09-09 00:00:00
abstract::The present study investigates the effect of galactosylated gelatin on encapsulated HepG2 cells. Methacrylamide modified gelatin is evaluated and compared with its galactosylated counterpart with respect to effects on viability, morphological characteristics, proliferation, and the expression of hepatocyte specific ma...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300320
更新日期:2014-03-01 00:00:00
abstract::The synthesis of a zwitterionic polymer, poly-sulfobetaine (poly-SPB), which shows remarkable efficiency in the suppression of insulin aggregation is described. Hydrophobic modification of the polymer results in almost complete inhibition at very low polymer concentrations. Further studies reveal that these polymers f...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800016
更新日期:2018-06-01 00:00:00
abstract::Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhes...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700313
更新日期:2008-06-11 00:00:00
abstract::Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Theref...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201200132
更新日期:2012-10-01 00:00:00
abstract::Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201700209
更新日期:2018-01-01 00:00:00
abstract::Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into sc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700141
更新日期:2017-11-01 00:00:00
abstract::Complexed poly(3-hydroxyalkanoate)s (cPHAs), one of two types of natural PHAs, occur in both prokaryotes and eukaryotes as a complex with biomacromolecules and could be involved in various physiological functions. In this study, a cPHA-component derived from a complex with calcium polyphosphate was isolated from sugar...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500111
更新日期:2005-09-16 00:00:00
abstract::To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with inc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600256
更新日期:2007-05-10 00:00:00
abstract::The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500030
更新日期:2005-07-14 00:00:00
abstract::An arginine-leucine block copolypeptide (R60 L20 ) is synthesized, which is capable of forming vesicles with controllable sizes, able to transport hydrophilic cargo across the cell membrane, and exhibit relatively low cytotoxicity. The R60 L20 vesicles also possess the ability to deliver DNA into mammalian cells for t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200383
更新日期:2013-05-01 00:00:00
abstract::To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500249
更新日期:2006-06-16 00:00:00