Combined Delivery of a Lipopolysaccharide-Binding Peptide and the Heme Oxygenase-1 Gene Using Deoxycholic Acid-Conjugated Polyethylenimine for the Treatment of Acute Lung Injury.

abstract：:Blend films of silk fibroin and carboxymethyl chitin were prepared by solution casting using water as a cosolvent. The blend films were subjected to post-treatment with an aqueous methanol solution to induce beta-sheet formation of silk fibroin. The miscibility of the blend films both before and after methanol treatme...

journal_title：Macromolecular bioscience

authors： Wongpanit P,Tabata Y,Rujiravanit R

更新日期：2007-12-06 00:00:00

abstract：:There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug-resistant Gram-negative "superbugs," especially the problematic Pseudomonas aeruginosa. In this work, the incorporation of colistin, a potent lipopeptide into a self-healable hydrogel (via dynamic imine bond form...

journal_title：Macromolecular bioscience

authors： Zhu C,Zhao J,Kempe K,Wilson P,Wang J,Velkov T,Li J,Davis TP,Whittaker MR,Haddleton DM

更新日期：2017-02-01 00:00:00

abstract：:The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equiva...

journal_title：Macromolecular bioscience

authors： Gao SQ,Sun Y,Kopecková P,Peterson CM,Kopecek J

更新日期：2009-11-10 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:Tissue adhesives are an attractive class of biomaterials, which can serve as a treatment for meniscus tears. In this study, physicochemical and adhesive properties of novel biodegradable three-armed- and hyperbranched block copolymeric adhesives are evaluated. Additionally, their degradation in vitro and in vivo, and ...

journal_title：Macromolecular bioscience

authors： Bochyńska AI,Hannink G,Rongen JJ,Grijpma DW,Buma P

更新日期：2017-11-01 00:00:00

abstract：:An antioxidant microgel with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities is reported. Using computational design and genetic engineering methods, the main catalytic components of GPx are fabricated onto the surface of ferritin. The resulting seleno-ferritin (Se-Fn) monomers can self-ass...

journal_title：Macromolecular bioscience

authors： Gao Y,Hou C,Zhou L,Zhang D,Zhang C,Miao L,Wang L,Dong Z,Luo Q,Liu J

更新日期：2013-06-01 00:00:00

abstract：:Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...

journal_title：Macromolecular bioscience

authors： Imran ul-haq M,Lai BF,Kizhakkedathu JN

更新日期：2014-10-01 00:00:00

abstract：:Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, a family of β-galactoside-binding proteins, are known to play ...

journal_title：Macromolecular bioscience

authors： Freichel T,Heine V,Laaf D,Mackintosh EE,Sarafova S,Elling L,Snyder NL,Hartmann L

更新日期：2020-09-01 00:00:00

abstract：:Enzyme immobilization is of high interest for industrial applications. However, immobilization may compromise enzyme activity or stability due to the harsh conditions which have to be applied. The authors therefore present a new and improved crosslinked layer-by-layer (cLbL) approach. Two different model enzymes (acid...

journal_title：Macromolecular bioscience

authors： Sieber S,Siegrist S,Schwarz S,Porta F,Schenk SH,Huwyler J

更新日期：2017-08-01 00:00:00

abstract：:Stereolithography-assisted fabrication of hydrogels of carboxybetaine methacrylamide (CBMAA) and a α,ω-methacrylate poly(d,l-lactide-block-ethylene glycol-block- d,l-lactide) (MA-PDLLA-PEG-PDLLA-MA) telechelic triblock macromer is presented. This technique allows printing complex structures with gyroid interconnected ...

journal_title：Macromolecular bioscience

authors： Kostina NY,Blanquer S,Pop-Georgievski O,Rahimi K,Dittrich B,Höcherl A,Michálek J,Grijpma DW,Rodriguez-Emmenegger C

更新日期：2019-04-01 00:00:00

abstract：:Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trim...

journal_title：Macromolecular bioscience

authors： Jansen J,Mihov G,Feijen J,Grijpma DW

更新日期：2012-05-01 00:00:00

abstract：:Traditionally, conductive materials for electrodes are based on high modulus metals or alloys. Development of bioelectrodes that mimic the mechanical properties of the soft, low modulus tissues in which they are implanted is a rapidly expanding field of research. Many polymers exist that more closely match tissue mech...

journal_title：Macromolecular bioscience

authors： Patton AJ,Poole-Warren LA,Green RA

更新日期：2016-08-01 00:00:00

abstract：:Oligomerization of thiol-unprotected L-cysteine ethyl ester (Cys-OEt) catalyzed by proteinase K in aqueous solution has been used to synthesize oligo(L-cysteine) (OligoCys) with a well-defined chemical structure and relatively large degree of polymerization (DP) up to 16-17 (average 8.8). By using a high concentration...

journal_title：Macromolecular bioscience

authors： Ma Y,Sato R,Li Z,Numata K

更新日期：2016-01-01 00:00:00

abstract：:The antimicrobial activity of poly(alkyloxazoline) telechelics with one quaternary N,N-dimethyldodecylammonium (DDA) end group was found to be greatly controlled by the non-bioactive distal end group, the so-called satellite group. In systematic investigations, the nature of the latter groups was varied to explore the...

journal_title：Macromolecular bioscience

authors： Waschinski CJ,Herdes V,Schueler F,Tiller JC

更新日期：2005-02-23 00:00:00

abstract：:Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...

journal_title：Macromolecular bioscience

authors： Nijhuis AW,Leeuwenburgh SC,Jansen JA

更新日期：2010-11-10 00:00:00

abstract：:A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furtherm...

journal_title：Macromolecular bioscience

authors： Kitano H,Suzuki H,Kondo T,Sasaki K,Iwanaga S,Nakamura M,Ohno K,Saruwatari Y

更新日期：2011-04-08 00:00:00

abstract：:We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...

journal_title：Macromolecular bioscience

authors： Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MR

更新日期：2009-09-09 00:00:00

abstract：:Microspheres of amphiphilic multi-block poly(ester-ether)s (PEE)s and poly(ester-ether-amide)s (PEEA)s based on poly(epsilon-caprolactone) (PCL) were investigated as delivery systems for proteins. The interest was mainly focused on the effect of their molecular structure and composition on the overall properties of th...

journal_title：Macromolecular bioscience

authors： Quaglia F,Ostacolo L,Nese G,De Rosa G,La Rotonda MI,Palumbo R,Maglio G

更新日期：2005-10-20 00:00:00

abstract：:The random copolymer, poly[lactide-co-glycotide-co-(epsilon-caprolactone)] (PLGACL) diacrylate was prepared by ring-opening polymerization of L-lactide, glycolide, and epsilon-caprolactone initiated with tetra(ethylene glycol). The diacrylated polymers were extensively characterized. With a UV embossing method, these ...

journal_title：Macromolecular bioscience

authors： Zhu A,Chen R,Chan-Park MB

更新日期：2006-01-05 00:00:00

abstract：:Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...

journal_title：Macromolecular bioscience

authors： Chytil P,Koziolová E,Etrych T,Ulbrich K

更新日期：2018-01-01 00:00:00

abstract：:The effect of doping graphene oxide (GO) and reduced graphene oxide (rGO) into poly(ε-caprolactone) (PCL) membranes prepared by solvent induced phase separation is evaluated in terms of nanomaterial distribution and compatibility with neural stem cell growth and functional differentiation. Raman spectra analyses demon...

journal_title：Macromolecular bioscience

authors： Sánchez-González S,Diban N,Bianchi F,Ye H,Urtiaga A

更新日期：2018-11-01 00:00:00

abstract：:Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength ...

journal_title：Macromolecular bioscience

authors： Rajkhowa R,Gil ES,Kluge J,Numata K,Wang L,Wang X,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:PCL microspheres featuring a macroporous morphology and a bone-bioactive surface have been prepared. 'Camphene' was introduced to generate pores within the microsphere network. The pore size was variable from a few to tens to hundreds of microm depending on the Camphene/PCL ratio. Macropores (with sizes >50 microm) co...

journal_title：Macromolecular bioscience

authors： Hong SJ,Yu HS,Kim HW

更新日期：2009-07-07 00:00:00

abstract：:Molecularly imprinted polymers (MIPs) are synthetic affinity matrices capable of selective binding a specific target molecule. A strategy for competitive selectivity studies is developed providing information on the selective binding properties of MIPs in complex matrices. Batch rebinding experiments entail the target...

journal_title：Macromolecular bioscience

authors： Pluhar B,Mizaikoff B

更新日期：2015-11-01 00:00:00

abstract：:Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...

journal_title：Macromolecular bioscience

authors： Hiraishi T,Masuda E,Kanayama N,Nagata M,Doi Y,Abe H,Maeda M

更新日期：2009-01-09 00:00:00

abstract：:When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and q...

journal_title：Macromolecular bioscience

authors： Yang P

更新日期：2012-08-01 00:00:00

abstract：:Bioinks play a key role in determining the capability of the biofabricatoin processes and the resolution of the printed constructs. Excellent biocompatibility, tunable physical properties, and ease of chemical or biological modifications of gelatin methacryloyl (GelMA) have made it an attractive choice as bioinks for ...

journal_title：Macromolecular bioscience

authors： Kumar H,Sakthivel K,Mohamed MGA,Boras E,Shin SR,Kim K

更新日期：2021-01-01 00:00:00

abstract：:The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine and phenylalanine peptide synthons allow the assembly/disassembly to be adjusted in a physiologically relevant range of pH 5.3-6.0. Co...

journal_title：Macromolecular bioscience

authors： Ahlers P,Frisch H,Holm R,Spitzer D,Barz M,Besenius P

更新日期：2017-10-01 00:00:00

abstract：:Mussel-inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In this study, the initial adhesive behavior of human umbilical vein endothelial cells (HUVECs) is evaluated on a PDA coating under serum-free conditions. It is fou...

journal_title：Macromolecular bioscience

authors： Wang JL,Ren KF,Chang H,Jia F,Li BC,Ji Y,Ji J

更新日期：2013-04-01 00:00:00

abstract：:In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

journal_title：Macromolecular bioscience

authors： Fan J,Li Y,Jiang H,Tang G,Wang L

更新日期：2008-05-13 00:00:00