Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.

abstract：:Novel temperature-sensitive poly(N-isopropylacrylamide)/amine-terminated polyamidoamine dendrimer G6-NH2 hydrogels with fast responsive properties were synthesized by forming semi-interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temp...

journal_title：Macromolecular bioscience

authors： Zhang JT,Huang SW,Zhuo RX

更新日期：2004-06-25 00:00:00

abstract：:Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...

journal_title：Macromolecular bioscience

authors： Ouimet MA,Fogaça R,Snyder SS,Sathaye S,Catalani LH,Pochan DJ,Uhrich KE

更新日期：2015-03-01 00:00:00

abstract：:"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...

journal_title：Macromolecular bioscience

authors： Abebe DG,Kandil R,Kraus T,Elsayed M,Merkel OM,Fujiwara T

更新日期：2015-05-01 00:00:00

abstract：:Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Theref...

journal_title：Macromolecular bioscience

authors： Greiner AM,Richter B,Bastmeyer M

更新日期：2012-10-01 00:00:00

abstract：:The present study investigates the effect of galactosylated gelatin on encapsulated HepG2 cells. Methacrylamide modified gelatin is evaluated and compared with its galactosylated counterpart with respect to effects on viability, morphological characteristics, proliferation, and the expression of hepatocyte specific ma...

journal_title：Macromolecular bioscience

authors： Gevaert E,Billiet T,Declercq H,Dubruel P,Cornelissen R

更新日期：2014-03-01 00:00:00

abstract：:Surface structural characterisation of three different starch-based blends (with poly[ethylene-co-(vinyl alcohol)], cellulose acetate and polycaprolactone) was carried out. The results show that there is a difference between the bulk and the surface composition of all studied blends. Two different hypotheses were inve...

journal_title：Macromolecular bioscience

authors： Pashkuleva I,Azevedo HS,Reis RL

更新日期：2008-02-11 00:00:00

abstract：:The synthesis of a zwitterionic polymer, poly-sulfobetaine (poly-SPB), which shows remarkable efficiency in the suppression of insulin aggregation is described. Hydrophobic modification of the polymer results in almost complete inhibition at very low polymer concentrations. Further studies reveal that these polymers f...

journal_title：Macromolecular bioscience

authors： Rajan R,Suzuki Y,Matsumura K

更新日期：2018-06-01 00:00:00

abstract：:Nanoparticles (NP) represent a promising tool for biomedical applications. Here, sulfonate- and phosphonate-functionalized polystyrene NP are analyzed for their interaction with human monocyte-derived dendritic cells (DC). Immature dendritic cells (iDC) display a higher time- and dose-dependent uptake of functionalize...

journal_title：Macromolecular bioscience

authors： Frick SU,Bacher N,Baier G,Mailänder V,Landfester K,Steinbrink K

更新日期：2012-12-01 00:00:00

abstract：:High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can b...

journal_title：Macromolecular bioscience

authors： Bat E,van Kooten TG,Feijen J,Grijpma DW

更新日期：2011-07-07 00:00:00

abstract：:Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity. Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials. Chitosan is the most important derivative of ch...

journal_title：Macromolecular bioscience

authors： Xu H,Zhang L,Zhang H,Luo J,Gao X

更新日期：2021-01-18 00:00:00

abstract：:The effect of doping graphene oxide (GO) and reduced graphene oxide (rGO) into poly(ε-caprolactone) (PCL) membranes prepared by solvent induced phase separation is evaluated in terms of nanomaterial distribution and compatibility with neural stem cell growth and functional differentiation. Raman spectra analyses demon...

journal_title：Macromolecular bioscience

authors： Sánchez-González S,Diban N,Bianchi F,Ye H,Urtiaga A

更新日期：2018-11-01 00:00:00

abstract：:Injectable delivery systems have been widely used in tissue engineering as they can deliver cells into the body in a minimally invasive manner. In this study, it is hypothesized that microspheres with a similar size of cells could effectively form a shear reversible aggregate in the presence of cells and the aggregate...

journal_title：Macromolecular bioscience

authors： Woo E,Park H,Lee KY

更新日期：2014-05-01 00:00:00

abstract：:The properties of poly(D,L-lactide)-block-poly(2-hydroxyethyl acrylate) (PLA-b-PHEA) block copolymers by means of in vitro / in vivo (rat) degradation are investigated and compared to those of PLA homopolymer. Over 12 weeks, we observe mass loss and molecular weight decrease. In vitro and in vivo findings are very sim...

journal_title：Macromolecular bioscience

authors： Clément B,Decherchi P,Féron F,Bertin D,Gigmes D,Trimaille T,Marqueste T

更新日期：2011-09-09 00:00:00

abstract：:A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide-co-polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature-induced precipitation method, to get multila...

journal_title：Macromolecular bioscience

authors： Dorati R,De Trizio A,Marconi S,Ferrara A,Auricchio F,Genta I,Modena T,Benazzo M,Benazzo A,Volpato G,Conti B

更新日期：2017-06-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is an important protein for wound healing and angiogenesis in tissue engineering, but the lack of a viable delivery system hampers its clinical application. This study aims to maintain the long-term controlled release of bFGF by utilizing a collagen/heparin bi-affinity multilayer ...

journal_title：Macromolecular bioscience

authors： Hao W,Han J,Chu Y,Huang L,Zhuang Y,Sun J,Li X,Zhao Y,Chen Y,Dai J

更新日期：2018-11-01 00:00:00

abstract：:In drug delivery to the human brain, blood vessels are a significant hurdle because they restrict the entry of most solutes to protect brain. To overcome this hurdle, an in vitro 3D model for brain endothelial barrier is developed using a microfluidic device with hydrogel providing a 3D extracellular matrix scaffold. ...

journal_title：Macromolecular bioscience

authors： Chung B,Kim J,Nam J,Kim H,Jeong Y,Liu HW,Cho Y,Kim YH,Oh HJ,Chung S

更新日期：2020-06-01 00:00:00

abstract：:Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trim...

journal_title：Macromolecular bioscience

authors： Jansen J,Mihov G,Feijen J,Grijpma DW

更新日期：2012-05-01 00:00:00

abstract：:A HBSP has been designed as a novel bifunctional enzyme model with SOD and GPx activity by host/guest-directed self-assembly of MnTPyP-M-Ad and 6-Te-diCD. The structure of the host/guest complex was elucidated by (1) H NMR spectra, and the HBSP was characterized by SEM, DLS and measurement of catalytic properties. In ...

journal_title：Macromolecular bioscience

authors： Yu S,Zhang W,Zhu J,Yin Y,Jin H,Zhou L,Luo Q,Xu J,Liu J

更新日期：2011-06-14 00:00:00

abstract：:Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...

journal_title：Macromolecular bioscience

authors： Basinska T

更新日期：2005-12-15 00:00:00

abstract：:Plasmid DNA (pDNA) is encapsulated into biocompatible microgels by an inverse microemulsion polymerization method. Plasmid DNA and doxorubicin are successfully released from pDNA microgels and their release profiles are characterized by appropriate release models. The co-delivery of genes and drugs from the microgels ...

journal_title：Macromolecular bioscience

authors： Costa D,Valente AJ,Miguel MG,Queiroz J

更新日期：2012-09-01 00:00:00

abstract：:The use of glycopolymer-functionalized resins (Resin-Glc), as a solid support, in column mode for bacterial/protein capture and quantification is explored. The Resin-Glc is synthesized from commercially available chloromethylated polystyrene resin and glycopolymer, and is characterized by fourier transform infrared sp...

journal_title：Macromolecular bioscience

authors： Ajish JK,Abraham HM,Subramanian M,Kumar KSA

更新日期：2020-12-18 00:00:00

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...

journal_title：Macromolecular bioscience

authors： Thielbeer F,Johansson EM,Chankeshwara SV,Bradley M

更新日期：2013-06-01 00:00:00

abstract：:Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...

journal_title：Macromolecular bioscience

authors： Imran ul-haq M,Lai BF,Kizhakkedathu JN

更新日期：2014-10-01 00:00:00

abstract：:The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...

journal_title：Macromolecular bioscience

authors： Bannwarth MB,Ebert S,Lauck M,Ziener U,Tomcin S,Jakob G,Münnemann K,Mailänder V,Musyanovych A,Landfester K

更新日期：2014-09-01 00:00:00

abstract：:The control of biofouling, which is the unwanted adsorption of biomolecules and organisms on solid surfaces, is a prerequisite for wider applicability of the functional materials that are currently being used in biomedical industries. One of the frequently used methods for controlling biofouling is the use of surface ...

journal_title：Macromolecular bioscience

authors： Jeong Y,Thuy LT,Ki SH,Ko S,Kim S,Cho WK,Choi JS,Kang SM

更新日期：2018-10-01 00:00:00

abstract：:A new anhydroribotrisaccharide monomer, A2B3LR (1), was synthesized and ROP was carried out to elucidate the polymerizability and to obtain oligosaccharide-branched polysaccharides with defined structures. The new trisaccharide monomer was found to be polymerized readily with BF(3) . OEt(2) as a catalyst at -40 degree...

journal_title：Macromolecular bioscience

authors： Yoshida D,Han S,Narita K,Hattori K,Yoshida T

更新日期：2009-07-07 00:00:00

abstract：:When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and q...

journal_title：Macromolecular bioscience

authors： Yang P

更新日期：2012-08-01 00:00:00

abstract：:Peptide dendrimers assembled by solid-phase peptide synthesis using a branching diamino acid at every 2(nd) or 3(rd) position provide readily accessible synthetic model systems for proteins and enzymes. They adopt a globular shape by topology rather than by folding. Peptide dendrimers of 2(nd) and 3(rd) generation fun...

journal_title：Macromolecular bioscience

authors： Delort E,Szöcs E,Widmer R,Siegenthaler H,Reymond JL

更新日期：2007-08-07 00:00:00

abstract：:3D printing has become an essential part of bone tissue engineering and attracts great attention for the fabrication of bioactive scaffolds. Combining this rapid manufacturing technique with chemical precipitation, biodegradable 3D scaffold composed of polymer matrix (polylactic acid and polyethylene glycol), ceramics...

journal_title：Macromolecular bioscience

authors： Li X,Wang Y,Wang Z,Qi Y,Li L,Zhang P,Chen X,Huang Y

更新日期：2018-06-01 00:00:00