Evaluation of Cell-Penetrating Peptides Using Microfluidic In Vitro 3D Brain Endothelial Barrier.

abstract：:Protein hydrophobic interaction has been considered the most important factor dominating protein folding, aggregation, gelling, self-assembly, adhesion, and cohesion properties. In this paper, morphology and phase separation of hydrophobic clusters, networks, and aggregates of soy globular protein polymers, induced by...

journal_title：Macromolecular bioscience

authors： Sun XS,Wang D,Zhang L,Mo X,Zhu L,Bolye D

更新日期：2008-04-09 00:00:00

abstract：:Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as...

journal_title：Macromolecular bioscience

authors： Matrella S,Vitiello C,Mella M,Vigliotta G,Izzo L

更新日期：2015-07-01 00:00:00

abstract：:Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...

journal_title：Macromolecular bioscience

authors： Imran ul-haq M,Lai BF,Kizhakkedathu JN

更新日期：2014-10-01 00:00:00

abstract：:Enzyme immobilization is of high interest for industrial applications. However, immobilization may compromise enzyme activity or stability due to the harsh conditions which have to be applied. The authors therefore present a new and improved crosslinked layer-by-layer (cLbL) approach. Two different model enzymes (acid...

journal_title：Macromolecular bioscience

authors： Sieber S,Siegrist S,Schwarz S,Porta F,Schenk SH,Huwyler J

更新日期：2017-08-01 00:00:00

abstract：:Aggregation of denatured or unfolded proteins establishes a large energy barrier to spontaneous recovery of protein form and function following traumatic injury, tissue cryopreservation, and biopharmaceutical storage. Some tissues utilize small heat shock proteins (sHSPs) to prevent irreversible aggregation, which all...

journal_title：Macromolecular bioscience

authors： Poellmann MJ,Sosnick TR,Meredith SC,Lee RC

更新日期：2017-02-01 00:00:00

abstract：:Two chondrogenic factors, Dex and TGF-beta1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-beta1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were s...

journal_title：Macromolecular bioscience

authors： Park K,Cho KJ,Kim JJ,Kim IH,Han DK

更新日期：2009-03-10 00:00:00

abstract：:In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: I...

journal_title：Macromolecular bioscience

authors： Dimde M,Sahle FF,Wycisk V,Steinhilber D,Camacho LC,Licha K,Lademann J,Haag R

更新日期：2017-10-01 00:00:00

abstract：:Biodegradable hydrogels were synthesized by the click reaction of 4-arm azido-terminated PEG differing in molecular weight (2,100 and 8,800) and two alkyne-terminated peptides: [alkyne]-GFLGK-[alkyne] and ([alkyne]-GFLG)(2)K. The physical properties of in situ formed hydrogels were examined. The hydrogels were highly ...

journal_title：Macromolecular bioscience

authors： Yang J,Jacobsen MT,Pan H,Kopecek J

更新日期：2010-04-08 00:00:00

abstract：:Three types of multilayer films made from poly(L-lysine)/hyaluronan, chitosan/hyaluronan, and poly(allylamine hydrochloride)/poly(L-glutamic acid), were used to investigate the interplay between film mechano-chemical properties and cell adhesion. We showed that C2C12 myoblast adhesion and proliferation depended on the...

journal_title：Macromolecular bioscience

authors： Boudou T,Crouzier T,Nicolas C,Ren K,Picart C

更新日期：2011-01-10 00:00:00

abstract：:Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and respons...

journal_title：Macromolecular bioscience

authors： Aksoy N,Akinci OF

更新日期：2004-05-17 00:00:00

abstract：:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

journal_title：Macromolecular bioscience

authors： Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

更新日期：2007-11-12 00:00:00

abstract：:Because of the high mortality of coronary atherosclerotic heart diseases, it is necessary to develop novel early detection methods for vulnerable atherosclerotic plaques. Phenotype transformation of vascular smooth muscle cells (VSMCs) plays a vital role in progressed atherosclerotic plaques. Osteopontin (OPN) is one ...

journal_title：Macromolecular bioscience

authors： Li S,Gou T,Wang Q,Chen M,Chen Z,Xu M,Wang Y,Han D,Cao R,Liu J,Liang P,Dai Z,Cao F

更新日期：2020-02-01 00:00:00

abstract：:Complexed poly(3-hydroxyalkanoate)s (cPHAs), one of two types of natural PHAs, occur in both prokaryotes and eukaryotes as a complex with biomacromolecules and could be involved in various physiological functions. In this study, a cPHA-component derived from a complex with calcium polyphosphate was isolated from sugar...

journal_title：Macromolecular bioscience

authors： Suzuki Y,Esumi Y,Koshino H,Doi Y

更新日期：2005-09-16 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:Recently, the Foresight Institute has pronounced six economic challenges that can be addressed through the progress of nanotechnology. One of these is the health and longevity of human life. Amongst applications anticipated to provide a solution to this challenge, gene therapy appears to be particularly promising. In ...

journal_title：Macromolecular bioscience

authors： Lamarre B,Ryadnov MG

更新日期：2011-04-08 00:00:00

abstract：:Local, micromechanical environment is known to influence cellular function in heterogeneous hydrogels, and knowledge gained in micromechanics will facilitate the improved design of biomaterials for tissue regeneration. In this study, a system comprising microstructured resilin-like polypeptide (RLP)-poly(ethylene glyc...

journal_title：Macromolecular bioscience

authors： Lau HK,Rattan S,Fu H,Garcia CG,Barber DM,Kiick KL,Crosby AJ

更新日期：2020-05-01 00:00:00

abstract：:Back Cover: The authors have created polymers which release insulin using light. These materials utilize insulin itself as the primary monomer and therefore achieve a very high density (85% w/w insulin). This near perfect density makes them ideal as photoactivated depots of insulin. Further details can be found in the...

journal_title：Macromolecular bioscience

authors： Sarode BR,Jain PK,Friedman SH

更新日期：2016-08-01 00:00:00

abstract：:Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhes...

journal_title：Macromolecular bioscience

authors： Hsiong SX,Cooke PH,Kong HJ,Fishman ML,Ericsson M,Mooney DJ

更新日期：2008-06-11 00:00:00

abstract：:Desferrioxamine (DFO) is a clinically approved, high affinity iron chelator used for the treatment of iron overload. Due to its short half-life and toxicity, DFO is administered for 8-12 h per day, 5-7 d per week. In this manuscript, the influence of molecular properties of hyperbranched polyglycerol (HPG)-DFO conjuga...

journal_title：Macromolecular bioscience

authors： Hamilton JL,Ul-Haq MI,Creagh AL,Haynes CA,Kizhakkedathu JN

更新日期：2017-03-01 00:00:00

abstract：:The antimicrobial activity of poly(alkyloxazoline) telechelics with one quaternary N,N-dimethyldodecylammonium (DDA) end group was found to be greatly controlled by the non-bioactive distal end group, the so-called satellite group. In systematic investigations, the nature of the latter groups was varied to explore the...

journal_title：Macromolecular bioscience

authors： Waschinski CJ,Herdes V,Schueler F,Tiller JC

更新日期：2005-02-23 00:00:00

abstract：:Mussel-inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In this study, the initial adhesive behavior of human umbilical vein endothelial cells (HUVECs) is evaluated on a PDA coating under serum-free conditions. It is fou...

journal_title：Macromolecular bioscience

authors： Wang JL,Ren KF,Chang H,Jia F,Li BC,Ji Y,Ji J

更新日期：2013-04-01 00:00:00

abstract：:Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to b...

journal_title：Macromolecular bioscience

authors： Khan F,Ahmad SR

更新日期：2013-04-01 00:00:00

abstract：:High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can b...

journal_title：Macromolecular bioscience

authors： Bat E,van Kooten TG,Feijen J,Grijpma DW

更新日期：2011-07-07 00:00:00

abstract：:Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine pro...

journal_title：Macromolecular bioscience

authors： Cabanlit M,Maitland D,Wilson T,Simon S,Wun T,Gershwin ME,Van de Water J

更新日期：2007-01-05 00:00:00

abstract：:"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...

journal_title：Macromolecular bioscience

authors： Abebe DG,Kandil R,Kraus T,Elsayed M,Merkel OM,Fujiwara T

更新日期：2015-05-01 00:00:00

abstract：:Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into sc...

journal_title：Macromolecular bioscience

authors： Thamm C,DeSimone E,Scheibel T

更新日期：2017-11-01 00:00:00

abstract：:The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...

journal_title：Macromolecular bioscience

authors： Souza Campelo C,Chevallier P,Loy C,Silveira Vieira R,Mantovani D

更新日期：2020-01-01 00:00:00

abstract：:A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...

journal_title：Macromolecular bioscience

authors： Soeda Y,Toshima K,Matsumura S

更新日期：2005-04-19 00:00:00

abstract：:S-Layer proteins are an example of bionanostructures that can be exploited in nanofabrication. In addition to their ordered structure, the ability to self-assembly is a key feature that makes them a promising technological tool. Here, in vitro self-assembly kinetics of SpbA was investigated, and found that it occurs a...

journal_title：Macromolecular bioscience

authors： Teixeira LM,Strickland A,Mark SS,Bergkvist M,Sierra-Sastre Y,Batt CA

更新日期：2010-02-11 00:00:00

abstract：:Emphasizing the role of hydrogel stiffness and cellular differentiation, this study develops collagen and elastin-like polypeptide (ELP)-based bone regenerative hydrogels loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) and doxycycline with mechanical properties suitable for osteogenesis. The drug-...

journal_title：Macromolecular bioscience

authors： Pal P,Nguyen QC,Benton AH,Marquart ME,Janorkar AV

更新日期：2019-09-01 00:00:00