Abstract:
:The antimicrobial activity of poly(alkyloxazoline) telechelics with one quaternary N,N-dimethyldodecylammonium (DDA) end group was found to be greatly controlled by the non-bioactive distal end group, the so-called satellite group. In systematic investigations, the nature of the latter groups was varied to explore the mechanism of the satellite effect. To this end, poly(2-alkyl-1,3-oxazoline)s (alkyl = ethyl, methyl) with a DDA-group at the terminating end and varying alkyl, aminoalkyl, and polyphenyloxazoline block satellite groups, have been synthesized. Poly(oxazoline) derivatives with polydispersity indices of 1.06-1.20 and molecular weights from 2,200 to 12,800 g . mol(-1) could be obtained. The macromolecular structures have been confirmed by NMR spectroscopy and ESI-MS measurements. The polymers were investigated with regard to their antibacterial efficiency towards the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli. It was found that the introduction of alkyl chain satellites of 4-10 carbon atoms in length afforded antimicrobial activity of the polymers against both microbes that was about 2-3 times higher than that of the well-known structurally comparable low molecular weight biocide, dodecyltrimethylammonium chloride (DTAC). Based on the antimicrobial effects of the investigated polymers, a mechanism for the satellite effect was proposed.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Waschinski CJ,Herdes V,Schueler F,Tiller JCdoi
10.1002/mabi.200400169subject
Has Abstractpub_date
2005-02-23 00:00:00pages
149-56issue
2eissn
1616-5187issn
1616-5195journal_volume
5pub_type
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