Hybrid polyglycerols with long blood circulation: synthesis, biocompatibility, and biodistribution.

abstract：:In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scann...

journal_title：Macromolecular bioscience

authors： Chen F,Manandhar P,Ahmed MS,Chang S,Panday N,Zhang H,Moon JH,He J

更新日期：2019-02-01 00:00:00

abstract：:Bleeding complications usually cause significant morbidity and mortality in civilian and military populations. In clinical application, hemostatic sponges, gauzes, hydrogel, and bandages are widely used as the traditional effective hemostatic products for hemorrhage. However, the traditional hemostatic devices or agen...

journal_title：Macromolecular bioscience

authors： Chen Y,Wu L,Li P,Hao X,Yang X,Xi G,Liu W,Feng Y,He H,Shi C

更新日期：2020-04-01 00:00:00

abstract：:The preparation of mono- and multifilament sutures incorporating ibuprofen as an anti-inflammatory agent is considered. Poly(p-dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a...

journal_title：Macromolecular bioscience

authors： Zurita R,Puiggalí J,Rodríguez-Galán A

更新日期：2006-09-15 00:00:00

abstract：:Polymeric nanostructures obtained through self-assembly of reduction-sensitive amphiphilic triblock copolymers were investigated as potential drug delivery systems. The characteristic feature of these polymers is their cleavable disulfide bond in the center of the hydrophobic block. Therefore, the triblock copolymers ...

journal_title：Macromolecular bioscience

authors： Toughraï S,Malinova V,Masciadri R,Menon S,Tanner P,Palivan C,Bruns N,Meier W

更新日期：2015-04-01 00:00:00

abstract：:The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-solubl...

journal_title：Macromolecular bioscience

authors： Restani RB,Conde J,Pires RF,Martins P,Fernandes AR,Baptista PV,Bonifácio VD,Aguiar-Ricardo A

更新日期：2015-08-01 00:00:00

abstract：:The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

journal_title：Macromolecular bioscience

authors： Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

更新日期：2018-02-01 00:00:00

abstract：:Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, a family of β-galactoside-binding proteins, are known to play ...

journal_title：Macromolecular bioscience

authors： Freichel T,Heine V,Laaf D,Mackintosh EE,Sarafova S,Elling L,Snyder NL,Hartmann L

更新日期：2020-09-01 00:00:00

abstract：:A simple, robust one pot procedure for the preparation of waterborne multifunctional poly(vinyl amine)s (PVAms) is presented. By post-polymerization modification of PVAm with a bifunctional coupler and functional couplers cationic, reactive azetidinium groups, and alkyl chains are introduced in the side chains of PVAm...

journal_title：Macromolecular bioscience

authors： Chattopadhyay S,Heine ET,Keul H,Möller M

更新日期：2014-08-01 00:00:00

abstract：:The supramolecular self-assembly of macromonomers may serve as a first step to prepare well-defined, highly functionalized, hierarchically structured, conjugated polymers. Functional diacetylene macromonomers equipped with an oligopeptide segment designed to promote self-assembly into parallel beta-sheet type structur...

journal_title：Macromolecular bioscience

authors： Jahnke E,Millerioux AS,Severin N,Rabe JP,Frauenrath H

更新日期：2007-02-12 00:00:00

abstract：:A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...

journal_title：Macromolecular bioscience

authors： Ai X,Sun J,Zhong L,Wu C,Niu H,Xu T,Lian H,Han X,Ren G,Ding W,Wang J,Pu X,He Z

更新日期：2014-10-01 00:00:00

abstract：:O-carboxymethylchitin (molecular weight = 1.07 x 10(5), degree of carboxymethylation = 80%, degree of N-acetylation = 91%) was chemically attached to superoxide dismutase by the formation of amide linkages through a carbodiimide catalyzed reaction. The glycosidated enzyme contained about 1.8 mole of polysaccharide per...

journal_title：Macromolecular bioscience

authors： Valdivia A,Perez Y,Dominguez A,Caballero J,Gomez L,Schacht EH,Villalonga R

更新日期：2005-02-23 00:00:00

abstract：:Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl ...

journal_title：Macromolecular bioscience

authors： Koschella A,Inngjerdingen K,Paulsen BS,Morris GA,Harding SE,Heinze T

更新日期：2008-01-09 00:00:00

abstract：:Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose (BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall p...

journal_title：Macromolecular bioscience

authors： Leitão AF,Faria MA,Faustino AM,Moreira R,Mela P,Loureiro L,Silva I,Gama M

更新日期：2016-01-01 00:00:00

abstract：:Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and s...

journal_title：Macromolecular bioscience

authors： Upadhyay KK,Bhatt AN,Castro E,Mishra AK,Chuttani K,Dwarakanath BS,Schatz C,Le Meins JF,Misra A,Lecommandoux S

更新日期：2010-05-14 00:00:00

abstract：:Traditionally, conductive materials for electrodes are based on high modulus metals or alloys. Development of bioelectrodes that mimic the mechanical properties of the soft, low modulus tissues in which they are implanted is a rapidly expanding field of research. Many polymers exist that more closely match tissue mech...

journal_title：Macromolecular bioscience

authors： Patton AJ,Poole-Warren LA,Green RA

更新日期：2016-08-01 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity. Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials. Chitosan is the most important derivative of ch...

journal_title：Macromolecular bioscience

authors： Xu H,Zhang L,Zhang H,Luo J,Gao X

更新日期：2021-01-18 00:00:00

abstract：:Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer stru...

journal_title：Macromolecular bioscience

authors： Valle J,Burgui S,Langheinrich D,Gil C,Solano C,Toledo-Arana A,Helbig R,Lasagni A,Lasa I

更新日期：2015-08-01 00:00:00

abstract：:Novel molecular ecological techniques were used to study changes in microbial community structure and population during degradation of polylactide (PLA)/organically modified layered silicates (OMLS) nanocomposites. Cloned gene sequences belonging to members of the phyla Actinobacteria and Ascomycota comprized the most...

journal_title：Macromolecular bioscience

authors： Sangwan P,Way C,Wu DY

更新日期：2009-07-07 00:00:00

abstract：:Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...

journal_title：Macromolecular bioscience

authors： Ignatova M,Manolova N,Rashkov I

更新日期：2013-07-01 00:00:00

abstract：:Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness...

journal_title：Macromolecular bioscience

authors： Schuurman W,Levett PA,Pot MW,van Weeren PR,Dhert WJ,Hutmacher DW,Melchels FP,Klein TJ,Malda J

更新日期：2013-05-01 00:00:00

abstract：:In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: I...

journal_title：Macromolecular bioscience

authors： Dimde M,Sahle FF,Wycisk V,Steinhilber D,Camacho LC,Licha K,Lademann J,Haag R

更新日期：2017-10-01 00:00:00

abstract：:A novel PEGylated biodegradable hyperbranched PEG-b-PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide-based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer ...

journal_title：Macromolecular bioscience

authors： Tao L,Chou WC,Tan BH,Davis TP

更新日期：2010-06-11 00:00:00

abstract：:Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion...

journal_title：Macromolecular bioscience

authors： He C,Li M,Zhang J,Yan B,Zhao W,Sun S,Zhao C

更新日期：2020-08-01 00:00:00

abstract：:Current methods of tissue fixation rely on mechanical-related technologies developed from the clothing and carpentry industries. Herein, a novel bioadhesive method that allows tuneable adhesion and is also applicable to biodegradable polyester substrates is described. Diazirine is the key functional group that allows ...

journal_title：Macromolecular bioscience

authors： Mogal V,Papper V,Chaurasia A,Feng G,Marks R,Steele T

更新日期：2014-04-01 00:00:00

abstract：:Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...

journal_title：Macromolecular bioscience

authors： Basinska T

更新日期：2005-12-15 00:00:00

abstract：:Biodegradable hydrogels were synthesized by the click reaction of 4-arm azido-terminated PEG differing in molecular weight (2,100 and 8,800) and two alkyne-terminated peptides: [alkyne]-GFLGK-[alkyne] and ([alkyne]-GFLG)(2)K. The physical properties of in situ formed hydrogels were examined. The hydrogels were highly ...

journal_title：Macromolecular bioscience

authors： Yang J,Jacobsen MT,Pan H,Kopecek J

更新日期：2010-04-08 00:00:00

abstract：:Recently, the Foresight Institute has pronounced six economic challenges that can be addressed through the progress of nanotechnology. One of these is the health and longevity of human life. Amongst applications anticipated to provide a solution to this challenge, gene therapy appears to be particularly promising. In ...

journal_title：Macromolecular bioscience

authors： Lamarre B,Ryadnov MG

更新日期：2011-04-08 00:00:00

abstract：:Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, ce...

journal_title：Macromolecular bioscience

authors： Dera R,Diliën H,Billen B,Gagliardi M,Rahimi N,Van Den Akker NMS,Molin DGM,Grandfils C,Adriaensens P,Guedens W,Cleij TJ

更新日期：2019-07-01 00:00:00

abstract：:Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...

journal_title：Macromolecular bioscience

authors： Dréan M,Debuigne A,Jérôme C,Goncalves C,Midoux P,Rieger J,Guégan P

更新日期：2018-04-01 00:00:00