Abstract:
:Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Schuurman W,Levett PA,Pot MW,van Weeren PR,Dhert WJ,Hutmacher DW,Melchels FP,Klein TJ,Malda Jdoi
10.1002/mabi.201200471subject
Has Abstractpub_date
2013-05-01 00:00:00pages
551-61issue
5eissn
1616-5187issn
1616-5195journal_volume
13pub_type
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