Green preparation process, characterization and antitumor effects of doxorubicin-BSA-dextran nanoparticles.

abstract：:The present study investigates the effect of galactosylated gelatin on encapsulated HepG2 cells. Methacrylamide modified gelatin is evaluated and compared with its galactosylated counterpart with respect to effects on viability, morphological characteristics, proliferation, and the expression of hepatocyte specific ma...

journal_title：Macromolecular bioscience

authors： Gevaert E,Billiet T,Declercq H,Dubruel P,Cornelissen R

更新日期：2014-03-01 00:00:00

abstract：:An increased structural variety expands the number of putative applications for cyanophycin (multi-l-arginyl-poly-[l-aspartic acid], CGP). Therefore, structural modifications of CGP are of major interest; these are commonly obtained by modification and optimization of the bacterial producing strain or by chemical modi...

journal_title：Macromolecular bioscience

authors： Wiefel L,Steinbüchel A

更新日期：2016-07-01 00:00:00

abstract：:An insoluble wheat proteins-based polymer networks with new functional groups and positive charges were prepared through grafting-coupling reactions. The networks were also flexible with a lower glass transition temperature since the existence of the grafted mobile segments. The multi-component/multi-phase systems bec...

journal_title：Macromolecular bioscience

authors： Kurniawan L,Qiao GG,Zhang X

更新日期：2009-01-09 00:00:00

abstract：:Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial c...

journal_title：Macromolecular bioscience

authors： Whittington CF,Yoder MC,Voytik-Harbin SL

更新日期：2013-09-01 00:00:00

abstract：:The use of glycopolymer-functionalized resins (Resin-Glc), as a solid support, in column mode for bacterial/protein capture and quantification is explored. The Resin-Glc is synthesized from commercially available chloromethylated polystyrene resin and glycopolymer, and is characterized by fourier transform infrared sp...

journal_title：Macromolecular bioscience

authors： Ajish JK,Abraham HM,Subramanian M,Kumar KSA

更新日期：2020-12-18 00:00:00

abstract：:Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly im...

journal_title：Macromolecular bioscience

authors： Sherrell PC,Cieślar-Pobuda A,Ejneby MS,Sammalisto L,Gelmi A,de Muinck E,Brask J,Łos MJ,Rafat M

更新日期：2017-07-01 00:00:00

abstract：:Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...

journal_title：Macromolecular bioscience

authors： Yu L,Xu K,Ge L,Wan W,Darabi A,Xing M,Zhong W

更新日期：2016-09-01 00:00:00

abstract：:Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and s...

journal_title：Macromolecular bioscience

authors： Upadhyay KK,Bhatt AN,Castro E,Mishra AK,Chuttani K,Dwarakanath BS,Schatz C,Le Meins JF,Misra A,Lecommandoux S

更新日期：2010-05-14 00:00:00

abstract：:We recently discovered that poly(aspartate) (PAA) hydrolase-1 from Pedobacter sp. KP-2 has a unique property of specifically cleaving the amide bond between β-aspartate units in thermally synthesized PAA (tPAA). In the present study, the enzymatic synthesis of poly(α-ethyl β-aspartate) (β-PAA) was performed by taking ...

journal_title：Macromolecular bioscience

authors： Hiraishi T,Masuda E,Miyamoto D,Kanayama N,Abe H,Maeda M

更新日期：2011-02-11 00:00:00

abstract：:Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...

journal_title：Macromolecular bioscience

authors： Thielbeer F,Johansson EM,Chankeshwara SV,Bradley M

更新日期：2013-06-01 00:00:00

abstract：:Recently, the Foresight Institute has pronounced six economic challenges that can be addressed through the progress of nanotechnology. One of these is the health and longevity of human life. Amongst applications anticipated to provide a solution to this challenge, gene therapy appears to be particularly promising. In ...

journal_title：Macromolecular bioscience

authors： Lamarre B,Ryadnov MG

更新日期：2011-04-08 00:00:00

abstract：:In many industrial applications, inadequate cell attachment can be a limitation, especially when serum-free media are used. Nitrogen-rich plasma-polymerised ethylene (PPE:N) exhibits high concentrations of polar groups that can help to promote the attachment of weakly adherent cell types. Tissue plasminogen activator-...

journal_title：Macromolecular bioscience

authors： Gigout A,Levasseur S,Girard-Lauriault PL,Buschmann MD,Wertheimer MR,Jolicoeur M

更新日期：2009-10-08 00:00:00

abstract：:Microspheres of amphiphilic multi-block poly(ester-ether)s (PEE)s and poly(ester-ether-amide)s (PEEA)s based on poly(epsilon-caprolactone) (PCL) were investigated as delivery systems for proteins. The interest was mainly focused on the effect of their molecular structure and composition on the overall properties of th...

journal_title：Macromolecular bioscience

authors： Quaglia F,Ostacolo L,Nese G,De Rosa G,La Rotonda MI,Palumbo R,Maglio G

更新日期：2005-10-20 00:00:00

abstract：:The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

journal_title：Macromolecular bioscience

authors： Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

更新日期：2018-02-01 00:00:00

abstract：:In situ self-assemblies of new biodegradable triblock PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA have been investigated in acetonitrile solution. At first, two series of PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA, respectively denoted as the P and Q triblock copolyester series, were prepared with fixed PBS block ((overline)...

journal_title：Macromolecular bioscience

authors： Jia L,Yin L,Li Y,Li Q,Yang J,Yu J,Shi Z,Fang Q,Cao A

更新日期：2005-06-24 00:00:00

abstract：:Development of artificial tissues providing the proper geometrical, mechanical, and environmental cues for cells is highly coveted in the field of tissue engineering. Recently, microfabrication strategies in combination with other chemistries have been utilized to capture the architectural complexity of intricate orga...

journal_title：Macromolecular bioscience

authors： Kim MH,Kumar SK,Shirahama H,Seo J,Lee JH,Zhdanov VP,Cho NJ

更新日期：2016-03-01 00:00:00

abstract：:The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is succe...

journal_title：Macromolecular bioscience

authors： Baldassarre F,Vergaro V,Scarlino F,De Santis F,Lucarelli G,Torre AD,Ciccarella G,Rinaldi R,Giannelli G,Leporatti S

更新日期：2012-05-01 00:00:00

abstract：:Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...

journal_title：Macromolecular bioscience

authors： Dréan M,Debuigne A,Jérôme C,Goncalves C,Midoux P,Rieger J,Guégan P

更新日期：2018-04-01 00:00:00

abstract：:The antiviral effects of the cationic acrylate polymer E100 on a panel of lipid-enveloped viruses and the interactions involved are studied. The treatment of several common viruses with E100 induced a dose-dependent inhibition of the infectivity of viruses below the detection limit of the assays employed. Similarly, t...

journal_title：Macromolecular bioscience

authors： Alasino RV,Bianco ID,Vitali MS,Zarzur JA,Beltramo DM

更新日期：2007-09-11 00:00:00

abstract：:Uniform stereo-complex microparticles ranging from nanometer to micrometer size are prepared by using stereo multiblock co-poly(rac-lactide)s (smb-PLAs) with different stereo-regularity. At comparable molecular weights, as the smb-PLA stereo-regularity decreases from 88% to 76%, the crystallinity of the microparticles...

journal_title：Macromolecular bioscience

authors： Hu J,Tang Z,Qiu X,Han Y,Du Q,Chen X,Jing X

更新日期：2005-12-15 00:00:00

abstract：:The immobilization of enzymes into polymer hydrogels is a versatile approach to improve their stability and utility in biotechnological and biomedical applications. However, these systems typically show limited enzyme activity, due to unfavorable pore dimensions and low enzyme accessibility. Here, 3D jet writing of wa...

journal_title：Macromolecular bioscience

authors： Steier A,Schmieg B,Irtel von Brenndorff Y,Meier M,Nirschl H,Franzreb M,Lahann J

更新日期：2020-09-01 00:00:00

abstract：:In this preliminary work we have prepared a fluorinated polymer capable of solubilizing an appreciable amount of O(2) and, at the same time, maintaining a higher water solubility than perfluoroalkanes investigated as injectable O(2) carriers. In particular, we describe the synthesis and characterization of a new macro...

journal_title：Macromolecular bioscience

authors： Mandracchia D,Piccionello AP,Pitarresi G,Pace A,Buscemi S,Giammona G

更新日期：2007-06-07 00:00:00

abstract：:In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...

journal_title：Macromolecular bioscience

authors： King WJ,Pytel NJ,Ng K,Murphy WL

更新日期：2010-06-11 00:00:00

abstract：:An electroactive amino/carboxyl-capped aniline tetramer (AT) is covalently grafted to the surface of hydroxyapatite (HA) nanoparticles to generate novel electroactive HA-AT nanoparticles. The amount of AT ranges from 16.5 to 34.0 wt% and is characterized by thermogravimetric analysis (TGA). The HA-AT nanoparticles are...

journal_title：Macromolecular bioscience

authors： Liu Y,Cui H,Zhuang X,Zhang P,Cui Y,Wang X,Wei Y,Chen X

更新日期：2013-03-01 00:00:00

abstract：:Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutro...

journal_title：Macromolecular bioscience

authors： Sacco P,Decleva E,Tentor F,Menegazzi R,Borgogna M,Paoletti S,Kristiansen KA,Vårum KM,Marsich E

更新日期：2017-11-01 00:00:00

abstract：:Multicellular tumor spheroid (MCTS) mimics microenvironment for tumor formation and provides predictive insight for in vivo tests. The hanging drop (HD) method of spheroid generation is cost effective, but it is limited by a long time duration for spheroid development and a low rate of formation of larger spheroids. T...

journal_title：Macromolecular bioscience

authors： R A V,Kumari S,Poddar P,Dhara D,Maiti S

更新日期：2020-08-01 00:00:00

abstract：:To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet a...

journal_title：Macromolecular bioscience

authors： Nagahama K,Ohya Y,Ouchi T

更新日期：2006-06-16 00:00:00

abstract：:Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...

journal_title：Macromolecular bioscience

authors： Ignatova M,Manolova N,Rashkov I

更新日期：2013-07-01 00:00:00

abstract：:The preclinical development of nanomedicines raises several challenges and requires a comprehensive characterization. Among them is the evaluation of the biodistribution following systemic administration. In previous work, the biocompatibility and in vitro targeting ability of a glycol chitosan (GC) based nanogel have...

journal_title：Macromolecular bioscience

authors： Pereira P,Correia A,Gama FM

更新日期：2016-03-01 00:00:00

abstract：:Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Micro...

journal_title：Macromolecular bioscience

authors： Mathew AP,Oksman K,Pierron D,Harmand MF

更新日期：2013-03-01 00:00:00