Abstract:
:Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-addition of coumarin moieties, the hydrogels exhibit excellent self-healing capacity when they are exposed to light with wavelengths at 280 and 365 nm, respectively. To enhance cell compatibility, a poly (amidoamine) crosslinker is also synthesized. Variations in light exposure times and irradiation wavelengths are found to alter the self-healing property of the hydrogels. The hydrogels are shown to induce a regular cellular pattern. The hydrogels are used to regulate bone marrow stromal cells differentiation. The relative mRNA expressions are recorded to monitor the osteogenic differentiation of the cells.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Yu L,Xu K,Ge L,Wan W,Darabi A,Xing M,Zhong Wdoi
10.1002/mabi.201500457subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1381-90issue
9eissn
1616-5187issn
1616-5195journal_volume
16pub_type
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