Abstract:
:The antiviral effects of the cationic acrylate polymer E100 on a panel of lipid-enveloped viruses and the interactions involved are studied. The treatment of several common viruses with E100 induced a dose-dependent inhibition of the infectivity of viruses below the detection limit of the assays employed. Similarly, the treatment of human sera infected with HIV or HCV reduced virus RNA plasma levels to undetectable values. This implies that Eudragit E100 can interact with enveloped viruses, even in the presence of proteins, through a mechanism that is not reversed by titration of the positively charged groups of the polymer, opening the possibility to remove viral particles with the polymer as it is eliminated.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Alasino RV,Bianco ID,Vitali MS,Zarzur JA,Beltramo DMdoi
10.1002/mabi.200700102subject
Has Abstractpub_date
2007-09-11 00:00:00pages
1132-8issue
9-10eissn
1616-5187issn
1616-5195journal_volume
7pub_type
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