Abstract:
:Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24 h in MCF-7 and U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled PolyDOC t(1/2) and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Upadhyay KK,Bhatt AN,Castro E,Mishra AK,Chuttani K,Dwarakanath BS,Schatz C,Le Meins JF,Misra A,Lecommandoux Sdoi
10.1002/mabi.200900415subject
Has Abstractpub_date
2010-05-14 00:00:00pages
503-12issue
5eissn
1616-5187issn
1616-5195journal_volume
10pub_type
杂志文章abstract::The aggregative behaviors of hydroxypropylcellulose (HPC) molecules in aqueous solution and on substrates have been observed by employing laser light scattering (LLS) and, after deposition on a mica surface, atomic force microscopy (AFM). LLS studies showed that the HPC molecules formed large aggregates through self-a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600067
更新日期:2006-07-14 00:00:00
abstract::Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900358
更新日期:2010-06-11 00:00:00
abstract::Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer stru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500107
更新日期:2015-08-01 00:00:00
abstract::The antimicrobial activity of poly(alkyloxazoline) telechelics with one quaternary N,N-dimethyldodecylammonium (DDA) end group was found to be greatly controlled by the non-bioactive distal end group, the so-called satellite group. In systematic investigations, the nature of the latter groups was varied to explore the...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400169
更新日期:2005-02-23 00:00:00
abstract::Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1-5 wt%) as the B(4) reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico-mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200244
更新日期:2013-01-01 00:00:00
abstract::The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400122
更新日期:2014-09-01 00:00:00
abstract::Solution-grown chain-folded lamellar single crystals of poly(tetramethylene adipate) (PTMA) were prepared from a dilute solution of 2-methyl-1-propanol by isothermal crystallization. PTMA crystals were hexagonal-shaped and polyethylene decoration of the crystals resulted in a "six cross-sector" surface morphology and ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300086
更新日期:2004-03-15 00:00:00
abstract::This paper presents the analysis of the volume phase transition of ionic thermo-sensitive hydrogels to thermal stimulus through mathematical modelling. The model is termed the multi-effect-coupling thermal-stimulus (MECtherm) model and it considers the effects of multi-phases and multi-physics. Its application to stea...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500082
更新日期:2005-09-16 00:00:00
abstract::Molecularly imprinted polymers (MIPs) are synthetic affinity matrices capable of selective binding a specific target molecule. A strategy for competitive selectivity studies is developed providing information on the selective binding properties of MIPs in complex matrices. Batch rebinding experiments entail the target...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500106
更新日期:2015-11-01 00:00:00
abstract::A HBSP has been designed as a novel bifunctional enzyme model with SOD and GPx activity by host/guest-directed self-assembly of MnTPyP-M-Ad and 6-Te-diCD. The structure of the host/guest complex was elucidated by (1) H NMR spectra, and the HBSP was characterized by SEM, DLS and measurement of catalytic properties. In ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000478
更新日期:2011-06-14 00:00:00
abstract::The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700299
更新日期:2018-02-01 00:00:00
abstract::Integration of electrogenic microorganisms remains a challenge in biofuel cell technology. Here, synthetic biocomposites ("artificial biofilms") are proposed. Bacteria (Shewanella oneidensis) are embedded in a hydrogel matrix (poly(vinyl alcohol)) via wet- and electrospinning, creating fibers and nonwoven gauzes. The ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600442
更新日期:2017-07-01 00:00:00
abstract::Uniform stereo-complex microparticles ranging from nanometer to micrometer size are prepared by using stereo multiblock co-poly(rac-lactide)s (smb-PLAs) with different stereo-regularity. At comparable molecular weights, as the smb-PLA stereo-regularity decreases from 88% to 76%, the crystallinity of the microparticles...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500157
更新日期:2005-12-15 00:00:00
abstract::Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine pro...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600177
更新日期:2007-01-05 00:00:00
abstract::In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scann...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800271
更新日期:2019-02-01 00:00:00
abstract::Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400238
更新日期:2015-03-01 00:00:00
abstract::Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201000142
更新日期:2010-11-10 00:00:00
abstract::Three types of multilayer films made from poly(L-lysine)/hyaluronan, chitosan/hyaluronan, and poly(allylamine hydrochloride)/poly(L-glutamic acid), were used to investigate the interplay between film mechano-chemical properties and cell adhesion. We showed that C2C12 myoblast adhesion and proliferation depended on the...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000301
更新日期:2011-01-10 00:00:00
abstract::Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trim...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100468
更新日期:2012-05-01 00:00:00
abstract::In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross-linking agent for chitosan (CS). This biocompatible material cross-links and gels in minutes. The structure and morphology were characterized by various analyses. The results indicate that t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700035
更新日期:2007-09-11 00:00:00
abstract::A microfluidic technique is described to encapsulate living cells in alginate hydrogel microparticles generated from monodisperse double-emulsion templates. A microcapillary device is used to fabricate double emulsion templates composed of an alginate drop surrounded by a mineral oil shell. Hydrogel formation begins w...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100351
更新日期:2012-07-01 00:00:00
abstract::In order to impart antibacterial properties to microfibrous electrospun materials from styrene/maleic anhydride copolymers, quaternized chitosan derivatives (QCh) containing alkyl substituents of different chain lengths are covalently attached to the mats. A complete inhibition of the growth of bacteria, S. aureus (Gr...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100178
更新日期:2012-01-01 00:00:00
abstract::Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhes...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700313
更新日期:2008-06-11 00:00:00
abstract::pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lip...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000333
更新日期:2011-03-10 00:00:00
abstract::Protein hydrophobic interaction has been considered the most important factor dominating protein folding, aggregation, gelling, self-assembly, adhesion, and cohesion properties. In this paper, morphology and phase separation of hydrophobic clusters, networks, and aggregates of soy globular protein polymers, induced by...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700235
更新日期:2008-04-09 00:00:00
abstract::Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to b...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201200409
更新日期:2013-04-01 00:00:00
abstract::The immobilization of enzymes into polymer hydrogels is a versatile approach to improve their stability and utility in biotechnological and biomedical applications. However, these systems typically show limited enzyme activity, due to unfavorable pore dimensions and low enzyme accessibility. Here, 3D jet writing of wa...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000154
更新日期:2020-09-01 00:00:00
abstract::Novel water-insoluble, and reduction-responsive nonwoven scaffolds were fabricated from gamma-PGA and tested in cell culture. An electrospinning method was developed to produce scaffolds of fibers with diameters of 0.05-0.5 microm. Crosslinking of the fibers with cystamine in the presence of EDC resulted in water-inso...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800334
更新日期:2009-06-11 00:00:00
abstract::Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200455
更新日期:2013-06-01 00:00:00
abstract::In drug delivery to the human brain, blood vessels are a significant hurdle because they restrict the entry of most solutes to protect brain. To overcome this hurdle, an in vitro 3D model for brain endothelial barrier is developed using a microfluidic device with hydrogel providing a 3D extracellular matrix scaffold. ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900425
更新日期:2020-06-01 00:00:00