Extracellular Surface Potential Mapping by Scanning Ion Conductance Microscopy Revealed Transient Transmembrane Pore Formation Induced by Conjugated Polymer Nanoparticles.

abstract：:A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...

journal_title：Macromolecular bioscience

authors： Ai X,Sun J,Zhong L,Wu C,Niu H,Xu T,Lian H,Han X,Ren G,Ding W,Wang J,Pu X,He Z

更新日期：2014-10-01 00:00:00

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:Primary human megakaryocytes, the precursor cells of platelets, are difficult to collect and cultivate. Polymers that enrich these cells without affecting their regulation or function are of interest for basic research as well as for cord blood transplantation purposes since co-transplantation of enriched megakaryocyt...

journal_title：Macromolecular bioscience

authors： Hansen A,Corless S,Cleland A,Petrik J,Gilbert N,Bradley M

更新日期：2013-04-01 00:00:00

abstract：:The preparation of mono- and multifilament sutures incorporating ibuprofen as an anti-inflammatory agent is considered. Poly(p-dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a...

journal_title：Macromolecular bioscience

authors： Zurita R,Puiggalí J,Rodríguez-Galán A

更新日期：2006-09-15 00:00:00

abstract：:Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...

journal_title：Macromolecular bioscience

authors： Awada HK,Johnson NR,Wang Y

更新日期：2014-05-01 00:00:00

abstract：:In this study, GCC protein was used for the first time to construct a biodegradable conduit for peripheral nerve repair. The GCC was highly stable with a sufficiently high level of mechanical properties and it was non-toxic and non-apoptotic which could maintain the survival and outgrowth of Schwann cells. Noninvasive...

journal_title：Macromolecular bioscience

authors： Wang W,Lin JH,Tsai CC,Chuang HC,Ho CY,Yao CH,Chen YS

更新日期：2011-07-07 00:00:00

abstract：:The use of glycopolymer-functionalized resins (Resin-Glc), as a solid support, in column mode for bacterial/protein capture and quantification is explored. The Resin-Glc is synthesized from commercially available chloromethylated polystyrene resin and glycopolymer, and is characterized by fourier transform infrared sp...

journal_title：Macromolecular bioscience

authors： Ajish JK,Abraham HM,Subramanian M,Kumar KSA

更新日期：2020-12-18 00:00:00

abstract：:We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...

journal_title：Macromolecular bioscience

authors： Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MR

更新日期：2009-09-09 00:00:00

abstract：:An antioxidant microgel with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities is reported. Using computational design and genetic engineering methods, the main catalytic components of GPx are fabricated onto the surface of ferritin. The resulting seleno-ferritin (Se-Fn) monomers can self-ass...

journal_title：Macromolecular bioscience

authors： Gao Y,Hou C,Zhou L,Zhang D,Zhang C,Miao L,Wang L,Dong Z,Luo Q,Liu J

更新日期：2013-06-01 00:00:00

abstract：:Because of the high mortality of coronary atherosclerotic heart diseases, it is necessary to develop novel early detection methods for vulnerable atherosclerotic plaques. Phenotype transformation of vascular smooth muscle cells (VSMCs) plays a vital role in progressed atherosclerotic plaques. Osteopontin (OPN) is one ...

journal_title：Macromolecular bioscience

authors： Li S,Gou T,Wang Q,Chen M,Chen Z,Xu M,Wang Y,Han D,Cao R,Liu J,Liang P,Dai Z,Cao F

更新日期：2020-02-01 00:00:00

abstract：:Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(γ-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two polymers exhibit similar PBLG(-d7) composition, while in the ABC, the volume fraction of PEO block is ...

journal_title：Macromolecular bioscience

authors： Iatrou H,Dimas K,Gkikas M,Tsimblouli C,Sofianopoulou S

更新日期：2014-09-01 00:00:00

abstract：:In this study, PLLA nanofibers are fabricated by electrospinning and their surfaces are modified by laminin/chitosan (LN/CS) polyelectrolyte multilayer. Surface C/N ratio determined by XPS analysis quantitatively indicates of discrete coating layers on the nanofibers. The amount of LN deposited sustainably increases w...

journal_title：Macromolecular bioscience

authors： He L,Tang S,Prabhakaran MP,Liao S,Tian L,Zhang Y,Xue W,Ramakrishna S

更新日期：2013-11-01 00:00:00

abstract：:Polylaminin (polyLM) is a polymerized form of the extracellular matrix protein laminin obtained upon pH acidification. Here microscopy and spectroscopic tools are used to study the cell compatibility and the structural stability of polyLM, aiming at establishing its robustness as a biopolymer for therapeutic use. Poly...

journal_title：Macromolecular bioscience

authors： Freire E,Barroso MM,Klier RN,Coelho-Sampaio T

更新日期：2012-01-01 00:00:00

abstract：:Plant derived flavonoids have not been well explored in tissue engineering applications due to difficulties in efficient formulations with biomaterials for controlled presentation. Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L-lactic acid) (P...

journal_title：Macromolecular bioscience

authors： Madhurakkat Perikamana SK,Lee SM,Lee J,Ahmad T,Lee MS,Yang HS,Shin H

更新日期：2019-04-01 00:00:00

abstract：:Molecularly imprinted polymers (MIPs) are synthetic affinity matrices capable of selective binding a specific target molecule. A strategy for competitive selectivity studies is developed providing information on the selective binding properties of MIPs in complex matrices. Batch rebinding experiments entail the target...

journal_title：Macromolecular bioscience

authors： Pluhar B,Mizaikoff B

更新日期：2015-11-01 00:00:00

abstract：:Emphasizing the role of hydrogel stiffness and cellular differentiation, this study develops collagen and elastin-like polypeptide (ELP)-based bone regenerative hydrogels loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) and doxycycline with mechanical properties suitable for osteogenesis. The drug-...

journal_title：Macromolecular bioscience

authors： Pal P,Nguyen QC,Benton AH,Marquart ME,Janorkar AV

更新日期：2019-09-01 00:00:00

abstract：:A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furtherm...

journal_title：Macromolecular bioscience

authors： Kitano H,Suzuki H,Kondo T,Sasaki K,Iwanaga S,Nakamura M,Ohno K,Saruwatari Y

更新日期：2011-04-08 00:00:00

abstract：:Transparent, biodegradable, mechanically robust, and surface-patterned silk films were evaluated for the effect of surface morphology on human corneal fibroblast (hCF) cell proliferation, orientation, and ECM deposition and alignment. A series of dimensionally different surface groove patterns were prepared from optic...

journal_title：Macromolecular bioscience

authors： Gil ES,Park SH,Marchant J,Omenetto F,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:A ternary complex comprising plasmid DNA, lipopolysaccharide-binding peptide (LBP), and deoxycholic acid-conjugated polyethylenimine (PEI-DA) is prepared for combinational therapy of acute lung injury (ALI). The LBP is designed as an anti-inflammatory peptide based on the lipopolysaccharide (LPS)-binding domain of HMG...

journal_title：Macromolecular bioscience

authors： Kim JY,Piao C,Kim G,Lee S,Lee MS,Jeong JH,Lee M

更新日期：2017-08-01 00:00:00

abstract：:The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equiva...

journal_title：Macromolecular bioscience

authors： Gao SQ,Sun Y,Kopecková P,Peterson CM,Kopecek J

更新日期：2009-11-10 00:00:00

abstract：:In situ self-assemblies of new biodegradable triblock PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA have been investigated in acetonitrile solution. At first, two series of PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA, respectively denoted as the P and Q triblock copolyester series, were prepared with fixed PBS block ((overline)...

journal_title：Macromolecular bioscience

authors： Jia L,Yin L,Li Y,Li Q,Yang J,Yu J,Shi Z,Fang Q,Cao A

更新日期：2005-06-24 00:00:00

abstract：:Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...

journal_title：Macromolecular bioscience

authors： Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth T

更新日期：2012-06-01 00:00:00

abstract：:Plasmid DNA (pDNA) is encapsulated into biocompatible microgels by an inverse microemulsion polymerization method. Plasmid DNA and doxorubicin are successfully released from pDNA microgels and their release profiles are characterized by appropriate release models. The co-delivery of genes and drugs from the microgels ...

journal_title：Macromolecular bioscience

authors： Costa D,Valente AJ,Miguel MG,Queiroz J

更新日期：2012-09-01 00:00:00

abstract：:A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...

journal_title：Macromolecular bioscience

authors： Soeda Y,Toshima K,Matsumura S

更新日期：2005-04-19 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:The synthesis of a new glycomonomer based on mannose, prepared via CuAAC, is reported. The resulting 1,2,3-triazole linkage between mannose and the polymer backbone ensures the formation of highly stable glycopolymers, which will not undergo hydrolysis. The monomer 2'-(4-vinyl-[1,2,3]-triazol-1-yl)ethyl-O-alpha-D-mann...

journal_title：Macromolecular bioscience

authors： Hetzer M,Chen G,Barner-Kowollik C,Stenzel MH

更新日期：2010-02-11 00:00:00

abstract：:3D printing has become an essential part of bone tissue engineering and attracts great attention for the fabrication of bioactive scaffolds. Combining this rapid manufacturing technique with chemical precipitation, biodegradable 3D scaffold composed of polymer matrix (polylactic acid and polyethylene glycol), ceramics...

journal_title：Macromolecular bioscience

authors： Li X,Wang Y,Wang Z,Qi Y,Li L,Zhang P,Chen X,Huang Y

更新日期：2018-06-01 00:00:00

abstract：:In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...

journal_title：Macromolecular bioscience

authors： King WJ,Pytel NJ,Ng K,Murphy WL

更新日期：2010-06-11 00:00:00

abstract：:Nanoparticles (NP) represent a promising tool for biomedical applications. Here, sulfonate- and phosphonate-functionalized polystyrene NP are analyzed for their interaction with human monocyte-derived dendritic cells (DC). Immature dendritic cells (iDC) display a higher time- and dose-dependent uptake of functionalize...

journal_title：Macromolecular bioscience

authors： Frick SU,Bacher N,Baier G,Mailänder V,Landfester K,Steinbrink K

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducibl...

journal_title：Macromolecular bioscience

authors： Han H,Son S,Son S,Kim N,Yhee JY,Lee JH,Choi JS,Joo CK,Lee H,Lee D,Kim WJ,Kim SH,Kwon IC,Kim H,Kim K

更新日期：2016-11-01 00:00:00