Abstract:
:The preparation of mono- and multifilament sutures incorporating ibuprofen as an anti-inflammatory agent is considered. Poly(p-dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a significant change for the ibuprofen loaded samples in knot tensile assays. The kinetics of both the loading process and the release in a Sörensen's medium at 37 degrees C have been investigated. Diffusion coefficients have also been estimated from film and slab poly(p-dioxanone) samples containing ibuprofen and their release behavior compared to that shown by monofilaments. Release from a coating copolymer based on lactide, epsilon-caprolactone and trimethylene carbonate (PLA/PCA/PTMC 10/60/30) has also been studied. This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Zurita R,Puiggalí J,Rodríguez-Galán Adoi
10.1002/mabi.200600084subject
Has Abstractpub_date
2006-09-15 00:00:00pages
767-75issue
9eissn
1616-5187issn
1616-5195journal_volume
6pub_type
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