Abstract:
:HSVEC behavior under physiological shear stress in vitro is investigated on PET surfaces micropatterned with both RGDS and WQPPRARI peptides. This technique allows (i) creating geometries on surface to guide cell orientation under shear stress and (ii) controlling surface chemical composition in order to modulate cell behavior. Under shear stress, endothelial cells adhere on patterned PET surfaces and present a more rapid orientation in flow direction in comparison to cells cultured on homogeneous surfaces. Micropatterned surfaces presenting a large surface area ratio of RGDS/WQPPRARI peptides induce fibrillar adhesion, while surfaces presenting an equal RGDS/WQPPRARI peptides surface area ratio preferentially induce focal adhesion.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Chollet C,Bareille R,Rémy M,Guignandon A,Bordenave L,Laroche G,Durrieu MCdoi
10.1002/mabi.201200167subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1648-59issue
12eissn
1616-5187issn
1616-5195journal_volume
12pub_type
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