Synthetic, Chemically Defined Polymer-Coated Microcarriers for the Expansion of Human Mesenchymal Stem Cells.

abstract：:Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...

journal_title：Macromolecular bioscience

authors： Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth T

更新日期：2012-06-01 00:00:00

abstract：:Three different microbial wild-type strains are compared with respect to their potential as industrial scale polyhydroxyalkanoate (PHA) producers from the feed stock whey lactose. The halophilic archaeon Haloferax mediterranei as well as two eubacterial strains (Pseudomonas hydrogenovora and Hydrogenophaga pseudoflava...

journal_title：Macromolecular bioscience

authors： Koller M,Hesse P,Bona R,Kutschera C,Atlić A,Braunegg G

更新日期：2007-02-12 00:00:00

abstract：:Blend films of silk fibroin and carboxymethyl chitin were prepared by solution casting using water as a cosolvent. The blend films were subjected to post-treatment with an aqueous methanol solution to induce beta-sheet formation of silk fibroin. The miscibility of the blend films both before and after methanol treatme...

journal_title：Macromolecular bioscience

authors： Wongpanit P,Tabata Y,Rujiravanit R

更新日期：2007-12-06 00:00:00

abstract：:Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, m...

journal_title：Macromolecular bioscience

authors： Ben-Shabat S,Kumar N,Domb AJ

更新日期：2006-12-08 00:00:00

abstract：:A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create sin...

journal_title：Macromolecular bioscience

authors： Sun C,Jin X,Holzwarth JM,Liu X,Hu J,Gupte MJ,Zhao Y,Ma PX

更新日期：2012-06-01 00:00:00

abstract：:Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhes...

journal_title：Macromolecular bioscience

authors： Hsiong SX,Cooke PH,Kong HJ,Fishman ML,Ericsson M,Mooney DJ

更新日期：2008-06-11 00:00:00

abstract：:Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. In recent years, MB have also attracted interest as drug delivery systems. Soft-shelled lipidic MB tend to be more advantageous for US imaging, while hard-shelled polymeric MB appear to be more suitable for drug delivery purposes beca...

journal_title：Macromolecular bioscience

authors： Appold L,Shi Y,Rütten S,Kühne A,Pich A,Kiessling F,Lammers T

更新日期：2017-10-01 00:00:00

abstract：:Amylose-fatty acid inclusion complexes can be easily prepared by simple mixing in hot aqueous solutions. Above a critical chain length (C6) of the fatty acid insoluble complexes between amylose and each fatty acid (C8, C10, C12, C14, C16) were precipitated from the solution, and characterized by FT-IR, XRD, DSC, and S...

journal_title：Macromolecular bioscience

authors： Cao Z,Woortman AJ,Rudolf P,Loos K

更新日期：2015-05-01 00:00:00

abstract：:Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...

journal_title：Macromolecular bioscience

authors： Chytil P,Koziolová E,Etrych T,Ulbrich K

更新日期：2018-01-01 00:00:00

abstract：:When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and q...

journal_title：Macromolecular bioscience

authors： Yang P

更新日期：2012-08-01 00:00:00

abstract：:A ternary complex comprising plasmid DNA, lipopolysaccharide-binding peptide (LBP), and deoxycholic acid-conjugated polyethylenimine (PEI-DA) is prepared for combinational therapy of acute lung injury (ALI). The LBP is designed as an anti-inflammatory peptide based on the lipopolysaccharide (LPS)-binding domain of HMG...

journal_title：Macromolecular bioscience

authors： Kim JY,Piao C,Kim G,Lee S,Lee MS,Jeong JH,Lee M

更新日期：2017-08-01 00:00:00

abstract：:The random copolymer, poly[lactide-co-glycotide-co-(epsilon-caprolactone)] (PLGACL) diacrylate was prepared by ring-opening polymerization of L-lactide, glycolide, and epsilon-caprolactone initiated with tetra(ethylene glycol). The diacrylated polymers were extensively characterized. With a UV embossing method, these ...

journal_title：Macromolecular bioscience

authors： Zhu A,Chen R,Chan-Park MB

更新日期：2006-01-05 00:00:00

abstract：:The use of PLA and PLA-g-AA/starch as materials for the controlled release of encapsulated PSB was evaluated. The results showed that the bacterium degraded both the PLA and the PLA-g-AA/starch composite films, resulting in cell release. Severe disruption of the film structure occurred after incubation for 60-90 d. Th...

journal_title：Macromolecular bioscience

authors： Wu CS

更新日期：2008-06-11 00:00:00

abstract：:Aggregation is frequently encountered during coating nanoparticles, especially when the core is not solid and the coating polyelectrolytes are weak. Here, the coating of a nanoliposome with two weak polyelectrolytes, alginate and chitosan, is investigated. First, quartz crystal microbalance with dissipation, atomic fo...

journal_title：Macromolecular bioscience

authors： Nayef L,Castiello R,Tabrizian M

更新日期：2017-06-01 00:00:00

abstract：:Plasmid DNA (pDNA) is encapsulated into biocompatible microgels by an inverse microemulsion polymerization method. Plasmid DNA and doxorubicin are successfully released from pDNA microgels and their release profiles are characterized by appropriate release models. The co-delivery of genes and drugs from the microgels ...

journal_title：Macromolecular bioscience

authors： Costa D,Valente AJ,Miguel MG,Queiroz J

更新日期：2012-09-01 00:00:00

abstract：:A novel cell-supporting scaffold, Tetronic-oligolactide-heparin (TLH) hydrogel, was prepared by coupling heparin to polymerized Tetronic-oligolactide for use in improving tissue regeneration. Aqueous TLH solutions showed thermosensitive behavior, demonstrating potential for use as injectable hydrogels. The content and...

journal_title：Macromolecular bioscience

authors： Go DH,Joung YK,Lee SY,Lee MC,Park KD

更新日期：2008-12-08 00:00:00

abstract：:The preclinical development of nanomedicines raises several challenges and requires a comprehensive characterization. Among them is the evaluation of the biodistribution following systemic administration. In previous work, the biocompatibility and in vitro targeting ability of a glycol chitosan (GC) based nanogel have...

journal_title：Macromolecular bioscience

authors： Pereira P,Correia A,Gama FM

更新日期：2016-03-01 00:00:00

abstract：:BSA adsorption onto negatively and positively charged polystyrene nanoparticles was investigated. The nanoparticles were characterized in terms of particle size, zeta potential, surface group density, and morphology. The adsorption behavior of BSA on the particle surface, as a function of pH and overall charge of the ...

journal_title：Macromolecular bioscience

authors： Baier G,Costa C,Zeller A,Baumann D,Sayer C,Araujo PH,Mailänder V,Musyanovych A,Landfester K

更新日期：2011-05-12 00:00:00

abstract：:Biopolymers are an attractive class of compounds for being used in biomedical applications as they are widely available from biomass. Their drawback is the lack of mechanical stability and the ability to tune this properly. Covalent chemical cross-linking is an often used approach but it limits usability due to legisl...

journal_title：Macromolecular bioscience

authors： Kühn PT,Meijer TL,Schiavon I,van Poll M,van Aken J,Groen S,Kuijer R,van Kooten TG,van Rijn P

更新日期：2016-11-01 00:00:00

abstract：:The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-solubl...

journal_title：Macromolecular bioscience

authors： Restani RB,Conde J,Pires RF,Martins P,Fernandes AR,Baptista PV,Bonifácio VD,Aguiar-Ricardo A

更新日期：2015-08-01 00:00:00

abstract：:The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human ...

journal_title：Macromolecular bioscience

authors： Belanger K,Dinis TM,Taourirt S,Vidal G,Kaplan DL,Egles C

更新日期：2016-04-01 00:00:00

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:Pulmonary air leaks are medical complications of thoracic surgery for which fibrin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their ...

journal_title：Macromolecular bioscience

authors： Mizuta R,Taguchi T

更新日期：2017-04-01 00:00:00

abstract：:Primary human megakaryocytes, the precursor cells of platelets, are difficult to collect and cultivate. Polymers that enrich these cells without affecting their regulation or function are of interest for basic research as well as for cord blood transplantation purposes since co-transplantation of enriched megakaryocyt...

journal_title：Macromolecular bioscience

authors： Hansen A,Corless S,Cleland A,Petrik J,Gilbert N,Bradley M

更新日期：2013-04-01 00:00:00

abstract：:"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...

journal_title：Macromolecular bioscience

authors： Abebe DG,Kandil R,Kraus T,Elsayed M,Merkel OM,Fujiwara T

更新日期：2015-05-01 00:00:00

abstract：:Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...

journal_title：Macromolecular bioscience

authors： Strzelczyk AK,Paul TJ,Schmidt S

更新日期：2020-10-01 00:00:00

abstract：:Numerous hydrogel-based culture systems are used to create in vitro model for prevascularization. Hydrogels used to induce a microenvironment conducive to microvessel formation are typically soft and fast degradable, but often suffer from maintaining a lasting perfusable channel in vitro. Here, a dual hydrogel system ...

journal_title：Macromolecular bioscience

authors： Kim S,Pan CC,Yang YP

更新日期：2020-10-01 00:00:00

abstract：:Conducting polymers (CPs) is one of intelligent biomaterials with the specific properties of reversible redox states, which have a significant effects on the cell behaviors and nerve tissue regeneration. However, the effects of CPs with different electrical conductivity on the behaviors of nerve cells are rarely repor...

journal_title：Macromolecular bioscience

authors： Zhang S,Yan H,Yeh JM,Shi X,Zhang P

更新日期：2019-10-01 00:00:00

abstract：:Development of artificial tissues providing the proper geometrical, mechanical, and environmental cues for cells is highly coveted in the field of tissue engineering. Recently, microfabrication strategies in combination with other chemistries have been utilized to capture the architectural complexity of intricate orga...

journal_title：Macromolecular bioscience

authors： Kim MH,Kumar SK,Shirahama H,Seo J,Lee JH,Zhdanov VP,Cho NJ

更新日期：2016-03-01 00:00:00

abstract：:This paper presents the analysis of the volume phase transition of ionic thermo-sensitive hydrogels to thermal stimulus through mathematical modelling. The model is termed the multi-effect-coupling thermal-stimulus (MECtherm) model and it considers the effects of multi-phases and multi-physics. Its application to stea...

journal_title：Macromolecular bioscience

authors： Li H,Wang X,Wang Z,Lam KY

更新日期：2005-09-16 00:00:00