Abstract:
:A novel cell-supporting scaffold, Tetronic-oligolactide-heparin (TLH) hydrogel, was prepared by coupling heparin to polymerized Tetronic-oligolactide for use in improving tissue regeneration. Aqueous TLH solutions showed thermosensitive behavior, demonstrating potential for use as injectable hydrogels. The content and activity of conjugated heparin were determined to be 61 wt.-% of total polymer and 67.2% of intact heparin activity, respectively. The basic fibroblast growth factor (bFGF) binding assay showed TLH hydrogel had a relatively high bFGF affinity, which indicates applicability for growth factor delivery. Chondrocyte culture on hydrogels revealed that the cell viability and the amount of synthesized glycosaminoglycan for TLH hydrogel were higher than those for alginate gel.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Go DH,Joung YK,Lee SY,Lee MC,Park KDdoi
10.1002/mabi.200800098subject
Has Abstractpub_date
2008-12-08 00:00:00pages
1152-60issue
12eissn
1616-5187issn
1616-5195journal_volume
8pub_type
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