Zwitterionic Polymer Design that Inhibits Aggregation and Facilitates Insulin Refolding: Mechanistic Insights and Importance of Hydrophobicity.

abstract：:Primary human megakaryocytes, the precursor cells of platelets, are difficult to collect and cultivate. Polymers that enrich these cells without affecting their regulation or function are of interest for basic research as well as for cord blood transplantation purposes since co-transplantation of enriched megakaryocyt...

journal_title：Macromolecular bioscience

authors： Hansen A,Corless S,Cleland A,Petrik J,Gilbert N,Bradley M

更新日期：2013-04-01 00:00:00

abstract：:Mussel-inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In this study, the initial adhesive behavior of human umbilical vein endothelial cells (HUVECs) is evaluated on a PDA coating under serum-free conditions. It is fou...

journal_title：Macromolecular bioscience

authors： Wang JL,Ren KF,Chang H,Jia F,Li BC,Ji Y,Ji J

更新日期：2013-04-01 00:00:00

abstract：:In this study, PLLA nanofibers are fabricated by electrospinning and their surfaces are modified by laminin/chitosan (LN/CS) polyelectrolyte multilayer. Surface C/N ratio determined by XPS analysis quantitatively indicates of discrete coating layers on the nanofibers. The amount of LN deposited sustainably increases w...

journal_title：Macromolecular bioscience

authors： He L,Tang S,Prabhakaran MP,Liao S,Tian L,Zhang Y,Xue W,Ramakrishna S

更新日期：2013-11-01 00:00:00

abstract：:Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. In recent years, MB have also attracted interest as drug delivery systems. Soft-shelled lipidic MB tend to be more advantageous for US imaging, while hard-shelled polymeric MB appear to be more suitable for drug delivery purposes beca...

journal_title：Macromolecular bioscience

authors： Appold L,Shi Y,Rütten S,Kühne A,Pich A,Kiessling F,Lammers T

更新日期：2017-10-01 00:00:00

abstract：:Interaction of conjugated polymers with liposomes is an attractive approach that benefits from both systems' characteristics such as electroactivity and enhanced interaction with cells. Conjugated polymer-liposome complexes have been investigated for bioimaging, drug delivery, and photothermal therapy. Their fabricati...

journal_title：Macromolecular bioscience

authors： Eslami M,Zeglio E,Alosaimi G,Yan Y,Ruprai H,Macmillan A,Seidel J,Lauto A,Joukhdar H,Rnjak-Kovacina J,Mawad D

更新日期：2020-11-01 00:00:00

abstract：:Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage,...

journal_title：Macromolecular bioscience

authors： Vankayala R,Corber SR,Mac JT,Rao MP,Shafie M,Anvari B

更新日期：2018-04-01 00:00:00

abstract：:Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion...

journal_title：Macromolecular bioscience

authors： He C,Li M,Zhang J,Yan B,Zhao W,Sun S,Zhao C

更新日期：2020-08-01 00:00:00

abstract：:Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...

journal_title：Macromolecular bioscience

authors： Rachmawati R,Woortman AJ,Loos K

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study is to design a novel two-component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin-based dermal scaffold more robust for the treatment of the clinically challenging pres...

journal_title：Macromolecular bioscience

authors： Sharma V,Kohli N,Moulding D,Afolabi H,Hook L,Mason C,García-Gareta E

更新日期：2017-11-01 00:00:00

abstract：:An electroactive amino/carboxyl-capped aniline tetramer (AT) is covalently grafted to the surface of hydroxyapatite (HA) nanoparticles to generate novel electroactive HA-AT nanoparticles. The amount of AT ranges from 16.5 to 34.0 wt% and is characterized by thermogravimetric analysis (TGA). The HA-AT nanoparticles are...

journal_title：Macromolecular bioscience

authors： Liu Y,Cui H,Zhuang X,Zhang P,Cui Y,Wang X,Wei Y,Chen X

更新日期：2013-03-01 00:00:00

abstract：:Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to b...

journal_title：Macromolecular bioscience

authors： Khan F,Ahmad SR

更新日期：2013-04-01 00:00:00

abstract：:Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, ce...

journal_title：Macromolecular bioscience

authors： Dera R,Diliën H,Billen B,Gagliardi M,Rahimi N,Van Den Akker NMS,Molin DGM,Grandfils C,Adriaensens P,Guedens W,Cleij TJ

更新日期：2019-07-01 00:00:00

abstract：:Hydroxypropyl chitosan-graft-carboxymethyl beta-cyclodextrin (HPCH-g-CM beta-CD) was synthesized by grafting CM beta-CD onto HPCH using water soluble 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as the condensing agent. Due to the presence of hydrophobic beta-CD rings onto the HPCH backbone, this polymer can be...

journal_title：Macromolecular bioscience

authors： Prabaharan M,Mano JF

更新日期：2005-10-20 00:00:00

abstract：:Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential veh...

journal_title：Macromolecular bioscience

authors： Borke T,Najberg M,Ilina P,Bhattacharya M,Urtti A,Tenhu H,Hietala S

更新日期：2018-01-01 00:00:00

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:A facile and easily reproducible technique for assembling biohybrid nanoparticles is a core feature that is highly desired for biomedical applications, considering the nature and limited lifespan of the biopolymers used. Here we show a simple and effective method to enfold single-walled carbon nanotubes (SWNTs) using ...

journal_title：Macromolecular bioscience

authors： Kotagiri N,Kim JW

更新日期：2010-03-10 00:00:00

abstract：:Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

journal_title：Macromolecular bioscience

authors： Gañán P,Zuluaga R,Velez JM,Mondragon I

更新日期：2004-10-20 00:00:00

abstract：:Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to...

journal_title：Macromolecular bioscience

authors： Patil R,Gangalum PR,Wagner S,Portilla-Arias J,Ding H,Rekechenetskiy A,Konda B,Inoue S,Black KL,Ljubimova JY,Holler E

更新日期：2015-09-01 00:00:00

abstract：:Polylaminin (polyLM) is a polymerized form of the extracellular matrix protein laminin obtained upon pH acidification. Here microscopy and spectroscopic tools are used to study the cell compatibility and the structural stability of polyLM, aiming at establishing its robustness as a biopolymer for therapeutic use. Poly...

journal_title：Macromolecular bioscience

authors： Freire E,Barroso MM,Klier RN,Coelho-Sampaio T

更新日期：2012-01-01 00:00:00

abstract：:The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance propertie...

journal_title：Macromolecular bioscience

authors： Alavi M,Nokhodchi A

更新日期：2020-04-01 00:00:00

abstract：:Oligomerization of thiol-unprotected L-cysteine ethyl ester (Cys-OEt) catalyzed by proteinase K in aqueous solution has been used to synthesize oligo(L-cysteine) (OligoCys) with a well-defined chemical structure and relatively large degree of polymerization (DP) up to 16-17 (average 8.8). By using a high concentration...

journal_title：Macromolecular bioscience

authors： Ma Y,Sato R,Li Z,Numata K

更新日期：2016-01-01 00:00:00

abstract：:In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scann...

journal_title：Macromolecular bioscience

authors： Chen F,Manandhar P,Ahmed MS,Chang S,Panday N,Zhang H,Moon JH,He J

更新日期：2019-02-01 00:00:00

abstract：:In the last decade, substantial research in the field of post-plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly-ε-caprolacto...

journal_title：Macromolecular bioscience

authors： Desmet T,Billiet T,Berneel E,Cornelissen R,Schaubroeck D,Schacht E,Dubruel P

更新日期：2010-12-08 00:00:00

abstract：:Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...

journal_title：Macromolecular bioscience

authors： Jia X,Kiick KL

更新日期：2009-02-11 00:00:00

abstract：:Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...

journal_title：Macromolecular bioscience

authors： Dréan M,Debuigne A,Jérôme C,Goncalves C,Midoux P,Rieger J,Guégan P

更新日期：2018-04-01 00:00:00

abstract：:A nanoformulation composed of curdlan, a linear polysaccharide of 1,3-β-linked d-glucose units, hydrogen bonded to poly(γ -glutamic acid) (PGA), was developed to stimulate macrophage. Curdlan/PGA nanoparticles (C-NP) are formulated by physically blending curdlan (0.2 mg mL-1 in 0.4 m NaOH) with PGA (0.8 mg mL-1 ). For...

journal_title：Macromolecular bioscience

authors： Heo J,Sobiech TA,Kutscher HL,Chaves L,Sukumaran DK,Karki S,Dube A,Prasad PN,Reynolds JL

更新日期：2021-01-01 00:00:00

abstract：:Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...

journal_title：Macromolecular bioscience

authors： Navarro L,Mogosanu DE,de Jong T,Bakker AD,Schaubroeck D,Luna J,Rintoul I,Vanfleteren J,Dubruel P

更新日期：2016-11-01 00:00:00

abstract：:Protein-polymer conjugates are widely used to improve the pharmacokinetic properties of therapeutic proteins. Commercially available conjugates employ poly(ethylene glycol) (PEG) as the protective polymer; however, PEG has a number of shortcomings, including non-biodegradability and immunogenicity, that call for the d...

journal_title：Macromolecular bioscience

authors： Steinbach T,Becker G,Spiegel A,Figueiredo T,Russo D,Wurm FR

更新日期：2017-10-01 00:00:00

abstract：:The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is succe...

journal_title：Macromolecular bioscience

authors： Baldassarre F,Vergaro V,Scarlino F,De Santis F,Lucarelli G,Torre AD,Ciccarella G,Rinaldi R,Giannelli G,Leporatti S

更新日期：2012-05-01 00:00:00

abstract：:Three types of multilayer films made from poly(L-lysine)/hyaluronan, chitosan/hyaluronan, and poly(allylamine hydrochloride)/poly(L-glutamic acid), were used to investigate the interplay between film mechano-chemical properties and cell adhesion. We showed that C2C12 myoblast adhesion and proliferation depended on the...

journal_title：Macromolecular bioscience

authors： Boudou T,Crouzier T,Nicolas C,Ren K,Picart C

更新日期：2011-01-10 00:00:00