Abstract:
:We report the self-assembly of a series of amphiphilic diblock copolymers comprising a biocompatible, hydrophilic block, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and a pH-sensitive block, poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), into a dispersion of colloidally stable, nanometer-sized polymersomes at physiological pH and salt concentration. The pH-sensitivity of the PDPA block affords the electrostatic interaction of these block copolymers with nucleic acids at endocytic pH, as a result of the protonation of its tertiary amine groups at pH values below its pK(a). Herein we investigate the effect of PDPA block length on the binding affinity of the block copolymer to plasmid DNA.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Lomas H,Du J,Canton I,Madsen J,Warren N,Armes SP,Lewis AL,Battaglia Gdoi
10.1002/mabi.201000083subject
Has Abstractpub_date
2010-05-14 00:00:00pages
513-30issue
5eissn
1616-5187issn
1616-5195journal_volume
10pub_type
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