Biofunctionalized Hydrogel Microscaffolds Promote 3D Hepatic Sheet Morphology.

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:PCL microspheres featuring a macroporous morphology and a bone-bioactive surface have been prepared. 'Camphene' was introduced to generate pores within the microsphere network. The pore size was variable from a few to tens to hundreds of microm depending on the Camphene/PCL ratio. Macropores (with sizes >50 microm) co...

journal_title：Macromolecular bioscience

authors： Hong SJ,Yu HS,Kim HW

更新日期：2009-07-07 00:00:00

abstract：:A generally applicable strategy to obtain mechanically robust hydrogels for the incorporation and containment of functional reporter bacteria for the microarray and microparticle-based detection and signaling of N-acyl homoserine lactone autoinducers (3OC12 HSL) at relevant concentrations is reported. For reinforcing ...

journal_title：Macromolecular bioscience

authors： Li P,Dou X,Müller M,Feng C,Chang MW,Frettlöh M,Schönherr H

更新日期：2017-11-01 00:00:00

abstract：:The fabrication of 3D cell microenvironments exploiting versatile, long-term stable passivating poly(acryl amide) brushes in a microwell format and the study of the behavior of fibroblast and pancreatic tumor cells in wells of systematically varied shape and size is reported. The microwells, which are obtained by comb...

journal_title：Macromolecular bioscience

authors： Lilge I,Jiang S,Schönherr H

更新日期：2017-05-01 00:00:00

abstract：:Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...

journal_title：Macromolecular bioscience

authors： Chytil P,Koziolová E,Etrych T,Ulbrich K

更新日期：2018-01-01 00:00:00

abstract：:Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...

journal_title：Macromolecular bioscience

authors： Ouimet MA,Fogaça R,Snyder SS,Sathaye S,Catalani LH,Pochan DJ,Uhrich KE

更新日期：2015-03-01 00:00:00

abstract：:A hybrid system for producing conducting polymers within a doping hydrogel mesh is presented. These conductive hydrogels demonstrate comparable electroactivity to conventional conducting polymers without requiring the need for mobile doping ions which are typically used in literature. These hybrids have superior mecha...

journal_title：Macromolecular bioscience

authors： Green RA,Hassarati RT,Goding JA,Baek S,Lovell NH,Martens PJ,Poole-Warren LA

更新日期：2012-04-01 00:00:00

abstract：:Molecularly imprinted polymers (MIPs) are synthetic affinity matrices capable of selective binding a specific target molecule. A strategy for competitive selectivity studies is developed providing information on the selective binding properties of MIPs in complex matrices. Batch rebinding experiments entail the target...

journal_title：Macromolecular bioscience

authors： Pluhar B,Mizaikoff B

更新日期：2015-11-01 00:00:00

abstract：:Aggregation of denatured or unfolded proteins establishes a large energy barrier to spontaneous recovery of protein form and function following traumatic injury, tissue cryopreservation, and biopharmaceutical storage. Some tissues utilize small heat shock proteins (sHSPs) to prevent irreversible aggregation, which all...

journal_title：Macromolecular bioscience

authors： Poellmann MJ,Sosnick TR,Meredith SC,Lee RC

更新日期：2017-02-01 00:00:00

abstract：:Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrica...

journal_title：Macromolecular bioscience

authors： Rasouli R,Barhoum A,Bechelany M,Dufresne A

更新日期：2019-02-01 00:00:00

abstract：:Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and respons...

journal_title：Macromolecular bioscience

authors： Aksoy N,Akinci OF

更新日期：2004-05-17 00:00:00

abstract：:Two chondrogenic factors, Dex and TGF-beta1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-beta1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were s...

journal_title：Macromolecular bioscience

authors： Park K,Cho KJ,Kim JJ,Kim IH,Han DK

更新日期：2009-03-10 00:00:00

abstract：:In this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extra...

journal_title：Macromolecular bioscience

authors： Ma L,Zhang Z,Li J,Yang X,Fei B,Leung PHM,Tao X

更新日期：2019-05-01 00:00:00

abstract：:In this work we report, compare and discuss the results obtained from fully atomistic molecular dynamics simulations of generations 4, 5, and 6 of PAMAM-based dendrimers having NH(3) and triethanolamine as cores, forming complexes with a short interfering RNA (siRNA) at different pH values and at physiological ionic ...

journal_title：Macromolecular bioscience

authors： Karatasos K,Posocco P,Laurini E,Pricl S

更新日期：2012-02-01 00:00:00

abstract：:pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lip...

journal_title：Macromolecular bioscience

authors： Zheng C,Yao X,Qiu L

更新日期：2011-03-10 00:00:00

abstract：:The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, inclu...

journal_title：Macromolecular bioscience

authors： Hsu SH,Tang CM,Chiu JJ,Liao TC,Lin CC,Iwata H

更新日期：2007-04-10 00:00:00

abstract：:The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human ...

journal_title：Macromolecular bioscience

authors： Belanger K,Dinis TM,Taourirt S,Vidal G,Kaplan DL,Egles C

更新日期：2016-04-01 00:00:00

abstract：:Polymeric nanostructures obtained through self-assembly of reduction-sensitive amphiphilic triblock copolymers were investigated as potential drug delivery systems. The characteristic feature of these polymers is their cleavable disulfide bond in the center of the hydrophobic block. Therefore, the triblock copolymers ...

journal_title：Macromolecular bioscience

authors： Toughraï S,Malinova V,Masciadri R,Menon S,Tanner P,Palivan C,Bruns N,Meier W

更新日期：2015-04-01 00:00:00

abstract：:Multicomponent systems for self-assembled molecular gels provide huge opportunities to generate collective or new functions that are not inherent in individual single-component gels. However, gelation tends to require careful and complicated procedures, because, among a myriad of kinetically trapped structures related...

journal_title：Macromolecular bioscience

authors： Hata Y,Kojima T,Maeda T,Sawada T,Serizawa T

更新日期：2020-09-01 00:00:00

abstract：:Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...

journal_title：Macromolecular bioscience

authors： Prasad S,Achazi K,Schade B,Haag R,Sharma SK

更新日期：2018-07-01 00:00:00

abstract：:Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...

journal_title：Macromolecular bioscience

authors： Basinska T

更新日期：2005-12-15 00:00:00

abstract：:Thermosensitive macroporous scaffolds of poly(N-isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin nanoparticles of 102 ± 6.5 nm diameter are prepared by complex coacervation and loaded into polyNIPA c...

journal_title：Macromolecular bioscience

authors： Peniche H,Reyes-Ortega F,Aguilar MR,Rodríguez G,Abradelo C,García-Fernández L,Peniche C,San Román J

更新日期：2013-11-01 00:00:00

abstract：:Integration of electrogenic microorganisms remains a challenge in biofuel cell technology. Here, synthetic biocomposites ("artificial biofilms") are proposed. Bacteria (Shewanella oneidensis) are embedded in a hydrogel matrix (poly(vinyl alcohol)) via wet- and electrospinning, creating fibers and nonwoven gauzes. The ...

journal_title：Macromolecular bioscience

authors： Kaiser P,Reich S,Leykam D,Willert-Porada M,Greiner A,Freitag R

更新日期：2017-07-01 00:00:00

abstract：:The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equiva...

journal_title：Macromolecular bioscience

authors： Gao SQ,Sun Y,Kopecková P,Peterson CM,Kopecek J

更新日期：2009-11-10 00:00:00

abstract：:Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many n...

journal_title：Macromolecular bioscience

authors： Jacobsen MM,Tokareva OS,Ebrahimi D,Huang W,Ling S,Dinjaski N,Li D,Simon M,Staii C,Buehler MJ,Kaplan DL,Wong JY

更新日期：2017-09-01 00:00:00

abstract：:Surface structural characterisation of three different starch-based blends (with poly[ethylene-co-(vinyl alcohol)], cellulose acetate and polycaprolactone) was carried out. The results show that there is a difference between the bulk and the surface composition of all studied blends. Two different hypotheses were inve...

journal_title：Macromolecular bioscience

authors： Pashkuleva I,Azevedo HS,Reis RL

更新日期：2008-02-11 00:00:00

abstract：:Amylose-fatty acid inclusion complexes can be easily prepared by simple mixing in hot aqueous solutions. Above a critical chain length (C6) of the fatty acid insoluble complexes between amylose and each fatty acid (C8, C10, C12, C14, C16) were precipitated from the solution, and characterized by FT-IR, XRD, DSC, and S...

journal_title：Macromolecular bioscience

authors： Cao Z,Woortman AJ,Rudolf P,Loos K

更新日期：2015-05-01 00:00:00

abstract：:The unicellular cyanobacterium Cyanothece sp. CCY 0110 is a highly efficient producer of extracellular polymeric substances (EPS), releasing up to 75% of the polymer to the culture medium. The carbohydrate polymer released to the medium (RPS) was previously isolated and characterized; it is composed of nine different ...

journal_title：Macromolecular bioscience

authors： Leite JP,Mota R,Durão J,Neves SC,Barrias CC,Tamagnini P,Gales L

更新日期：2017-02-01 00:00:00

abstract：:In order to impart antibacterial properties to microfibrous electrospun materials from styrene/maleic anhydride copolymers, quaternized chitosan derivatives (QCh) containing alkyl substituents of different chain lengths are covalently attached to the mats. A complete inhibition of the growth of bacteria, S. aureus (Gr...

journal_title：Macromolecular bioscience

authors： Ignatova M,Petkova Z,Manolova N,Markova N,Rashkov I

更新日期：2012-01-01 00:00:00

abstract：:The synthesis of a new glycomonomer based on mannose, prepared via CuAAC, is reported. The resulting 1,2,3-triazole linkage between mannose and the polymer backbone ensures the formation of highly stable glycopolymers, which will not undergo hydrolysis. The monomer 2'-(4-vinyl-[1,2,3]-triazol-1-yl)ethyl-O-alpha-D-mann...

journal_title：Macromolecular bioscience

authors： Hetzer M,Chen G,Barner-Kowollik C,Stenzel MH

更新日期：2010-02-11 00:00:00