Nanofibers for Biomedical and Healthcare Applications.


:Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue-engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core-shell nanofibers) fabricated from various materials and their potential biomedical applications.


Macromol Biosci


Rasouli R,Barhoum A,Bechelany M,Dufresne A




Has Abstract


2019-02-01 00:00:00












  • Entropically driven self-assembly of Lysinibacillus sphaericus S-layer proteins analyzed under various environmental conditions.

    abstract::S-Layer proteins are an example of bionanostructures that can be exploited in nanofabrication. In addition to their ordered structure, the ability to self-assembly is a key feature that makes them a promising technological tool. Here, in vitro self-assembly kinetics of SpbA was investigated, and found that it occurs a...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Teixeira LM,Strickland A,Mark SS,Bergkvist M,Sierra-Sastre Y,Batt CA

    更新日期:2010-02-11 00:00:00

  • Cytocompatible, Photoreversible, and Self-Healing Hydrogels for Regulating Bone Marrow Stromal Cell Differentiation.

    abstract::Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Yu L,Xu K,Ge L,Wan W,Darabi A,Xing M,Zhong W

    更新日期:2016-09-01 00:00:00

  • Reduction-sensitive amphiphilic triblock copolymers self-assemble into stimuli-responsive micelles for drug delivery.

    abstract::Polymeric nanostructures obtained through self-assembly of reduction-sensitive amphiphilic triblock copolymers were investigated as potential drug delivery systems. The characteristic feature of these polymers is their cleavable disulfide bond in the center of the hydrophobic block. Therefore, the triblock copolymers ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Toughraï S,Malinova V,Masciadri R,Menon S,Tanner P,Palivan C,Bruns N,Meier W

    更新日期:2015-04-01 00:00:00

  • Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability.

    abstract::Aggregation is frequently encountered during coating nanoparticles, especially when the core is not solid and the coating polyelectrolytes are weak. Here, the coating of a nanoliposome with two weak polyelectrolytes, alginate and chitosan, is investigated. First, quartz crystal microbalance with dissipation, atomic fo...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Nayef L,Castiello R,Tabrizian M

    更新日期:2017-06-01 00:00:00

  • Iron Binding and Iron Removal Efficiency of Desferrioxamine Based Polymeric Iron Chelators: Influence of Molecular Size and Chelator Density.

    abstract::Desferrioxamine (DFO) is a clinically approved, high affinity iron chelator used for the treatment of iron overload. Due to its short half-life and toxicity, DFO is administered for 8-12 h per day, 5-7 d per week. In this manuscript, the influence of molecular properties of hyperbranched polyglycerol (HPG)-DFO conjuga...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Hamilton JL,Ul-Haq MI,Creagh AL,Haynes CA,Kizhakkedathu JN

    更新日期:2017-03-01 00:00:00

  • Efficient encapsulation of plasmid DNA in pH-sensitive PMPC-PDPA polymersomes: study of the effect of PDPA block length on copolymer-DNA binding affinity.

    abstract::We report the self-assembly of a series of amphiphilic diblock copolymers comprising a biocompatible, hydrophilic block, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and a pH-sensitive block, poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), into a dispersion of colloidally stable, nanometer-sized polymers...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Lomas H,Du J,Canton I,Madsen J,Warren N,Armes SP,Lewis AL,Battaglia G

    更新日期:2010-05-14 00:00:00

  • Stabilization of gelatin nanoparticles without crosslinking.

    abstract::Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176 nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2%...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Khan SA,Schneider M

    更新日期:2014-11-01 00:00:00

  • Mitogenic activity of sulfated chitosan and cellulose derivatives is related to protection of FGF-2 from proteolytic cleavage.

    abstract::Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth T

    更新日期:2012-06-01 00:00:00

  • RAFT Emulsion Polymerization as a Platform to Generate Well-Defined Biocompatible Latex Nanoparticles.

    abstract::Current approaches to generate core-shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming t...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Gurnani P,Sanchez-Cano C,Abraham K,Xandri-Monje H,Cook AB,Hartlieb M,Lévi F,Dallmann R,Perrier S

    更新日期:2018-10-01 00:00:00

  • Reversible Bioconjugation: Biodegradable Poly(phosphate)-Protein Conjugates.

    abstract::Protein-polymer conjugates are widely used to improve the pharmacokinetic properties of therapeutic proteins. Commercially available conjugates employ poly(ethylene glycol) (PEG) as the protective polymer; however, PEG has a number of shortcomings, including non-biodegradability and immunogenicity, that call for the d...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Steinbach T,Becker G,Spiegel A,Figueiredo T,Russo D,Wurm FR

    更新日期:2017-10-01 00:00:00

  • Extracellular matrix-like surfactant polymers containing arginine-glycine-aspartic acid (RGD) peptides.

    abstract::We report on a novel series of biomimetic polymers exhibiting interfacial properties similar to the extracellular matrix. A series of well-defined surfactant polymers were synthesized by simultaneously incorporating arginine-glycine-aspartic acid (RGD) peptide, dextran oligosaccharide, and hexyl ligands with controlle...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Anderson EH,Ruegsegger MA,Murugesan G,Kottke-Marchant K,Marchant RE

    更新日期:2004-08-09 00:00:00

  • Sweet Vector for Gene Delivery: the Sugar Decoration of Polyplexes Reduces Cytotoxicity with a Balanced Effect on Gene Expression.

    abstract::The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

    更新日期:2018-02-01 00:00:00

  • Multipurpose Antifouling Coating of Solid Surfaces with the Marine-Derived Polymer Fucoidan.

    abstract::The control of biofouling, which is the unwanted adsorption of biomolecules and organisms on solid surfaces, is a prerequisite for wider applicability of the functional materials that are currently being used in biomedical industries. One of the frequently used methods for controlling biofouling is the use of surface ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Jeong Y,Thuy LT,Ki SH,Ko S,Kim S,Cho WK,Choi JS,Kang SM

    更新日期:2018-10-01 00:00:00

  • Novel peptide-shelled dendrimer with dramatically changeable thermo-responsive character.

    abstract::The preparation of a novel peptide/dendrimer hybrid is reported in which an elastin-like oligopeptide is successfully assembled onto a poly(amidoamine) dendrimer surface (G4-ELP), and its unique thermo-responsive behavior is discussed. As a result, the G4-ELP is found to exhibit LCST behavior in the pH range 3-10 incl...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Koga T,Iimura M,Higashi N

    更新日期:2012-08-01 00:00:00

  • Characterization of the inhibition of enveloped virus infectivity by the cationic acrylate polymer eudragit E100.

    abstract::The antiviral effects of the cationic acrylate polymer E100 on a panel of lipid-enveloped viruses and the interactions involved are studied. The treatment of several common viruses with E100 induced a dose-dependent inhibition of the infectivity of viruses below the detection limit of the assays employed. Similarly, t...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Alasino RV,Bianco ID,Vitali MS,Zarzur JA,Beltramo DM

    更新日期:2007-09-11 00:00:00

  • Hydrophilic core-shell microspheres: a suitable support for controlled attachment of proteins and biomedical diagnostics.

    abstract::Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审


    authors: Basinska T

    更新日期:2005-12-15 00:00:00

  • Cloning of poly(aspartic acid) (PAA) hydrolase-1 gene from Pedobacter sp. KP-2 and hydrolysis of thermally synthesized PAA by its gene product.

    abstract::Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Hiraishi T,Masuda E,Kanayama N,Nagata M,Doi Y,Abe H,Maeda M

    更新日期:2009-01-09 00:00:00

  • CHO cells adhering to nitrogen-rich plasma-polymerised ethylene exhibit high production of a specific recombinant protein.

    abstract::In many industrial applications, inadequate cell attachment can be a limitation, especially when serum-free media are used. Nitrogen-rich plasma-polymerised ethylene (PPE:N) exhibits high concentrations of polar groups that can help to promote the attachment of weakly adherent cell types. Tissue plasminogen activator-...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Gigout A,Levasseur S,Girard-Lauriault PL,Buschmann MD,Wertheimer MR,Jolicoeur M

    更新日期:2009-10-08 00:00:00

  • Reactive Self-Assembly and Specific Cellular Delivery of NCO-sP(EO-stat-PO)-Derived Nanogels.

    abstract::This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spheric...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Hildebrandt H,Paloheimo O,Mäntylä E,Willman S,Hakanen S,Albrecht K,Groll J,Möller M,Vihinen-Ranta M

    更新日期:2018-10-01 00:00:00

  • Influence of spacer length on the cellular uptake of polymeric nanoparticles.

    abstract::Nanotechnology is finding ever increasing application in the life science arena where nanoparticles can be used to deliver cargoes in cells. However, a clear understanding of the relationship between the chemical properties of the particle and its uptake efficiency is lacking. Herein, the effects on particle cellular ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Thielbeer F,Johansson EM,Chankeshwara SV,Bradley M

    更新日期:2013-06-01 00:00:00

  • A New Antimicrobial Agent: Poly (3-hydroxybutyric acid) Oligomer.

    abstract::In this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extra...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Ma L,Zhang Z,Li J,Yang X,Fei B,Leung PHM,Tao X

    更新日期:2019-05-01 00:00:00

  • Zwitterionic Functionalizable Scaffolds with Gyroid Pore Architecture for Tissue Engineering.

    abstract::Stereolithography-assisted fabrication of hydrogels of carboxybetaine methacrylamide (CBMAA) and a α,ω-methacrylate poly(d,l-lactide-block-ethylene glycol-block- d,l-lactide) (MA-PDLLA-PEG-PDLLA-MA) telechelic triblock macromer is presented. This technique allows printing complex structures with gyroid interconnected ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Kostina NY,Blanquer S,Pop-Georgievski O,Rahimi K,Dittrich B,Höcherl A,Michálek J,Grijpma DW,Rodriguez-Emmenegger C

    更新日期:2019-04-01 00:00:00

  • Crystal structure, thermal behavior and enzymatic degradation of poly(tetramethylene adipate) solution-grown chain-folded lamellar crystals.

    abstract::Solution-grown chain-folded lamellar single crystals of poly(tetramethylene adipate) (PTMA) were prepared from a dilute solution of 2-methyl-1-propanol by isothermal crystallization. PTMA crystals were hexagonal-shaped and polyethylene decoration of the crystals resulted in a "six cross-sector" surface morphology and ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Iwata T,Kobayashi S,Tabata K,Yonezawa N,Doi Y

    更新日期:2004-03-15 00:00:00

  • Quantifying Thermoswitchable Carbohydrate-Mediated Interactions via Soft Colloidal Probe Adhesion Studies.

    abstract::Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Strzelczyk AK,Paul TJ,Schmidt S

    更新日期:2020-10-01 00:00:00

  • Design of a Bioabsorbable Multilayered Patch for Esophagus Tissue Engineering.

    abstract::A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide-co-polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature-induced precipitation method, to get multila...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Dorati R,De Trizio A,Marconi S,Ferrara A,Auricchio F,Genta I,Modena T,Benazzo M,Benazzo A,Volpato G,Conti B

    更新日期:2017-06-01 00:00:00

  • Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics-Based Combination Antitumor Therapy.

    abstract::Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审


    authors: Yu S,He C,Chen X

    更新日期:2018-12-01 00:00:00

  • Study of the selective uptake progress of aptamer-modified PLGA particles by liver cells.

    abstract::It is of paramount importance to study the cellular uptake processes of particles with defined surface property, especially the uptake pathways and intracellular transportation. In this study, aptamer AS1411 molecules, which are known to specifically bind the over-expressed nucleolin on cancer cell membrane, were conj...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Yu D,Zhang Y,Mao Z,Gao C

    更新日期:2013-10-01 00:00:00

  • Development, Validation, and Performance of Chitosan-Based Coatings Using Catechol Coupling.

    abstract::The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Souza Campelo C,Chevallier P,Loy C,Silveira Vieira R,Mantovani D

    更新日期:2020-01-01 00:00:00

  • Disulfide-crosslinked electrospun poly(gamma-glutamic acid) nonwovens as reduction-responsive scaffolds.

    abstract::Novel water-insoluble, and reduction-responsive nonwoven scaffolds were fabricated from gamma-PGA and tested in cell culture. An electrospinning method was developed to produce scaffolds of fibers with diameters of 0.05-0.5 microm. Crosslinking of the fibers with cystamine in the presence of EDC resulted in water-inso...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Yoshida H,Klinkhammer K,Matsusaki M,Möller M,Klee D,Akashi M

    更新日期:2009-06-11 00:00:00

  • Multiphysics modelling of volume phase transition of ionic hydrogels responsive to thermal stimulus.

    abstract::This paper presents the analysis of the volume phase transition of ionic thermo-sensitive hydrogels to thermal stimulus through mathematical modelling. The model is termed the multi-effect-coupling thermal-stimulus (MECtherm) model and it considers the effects of multi-phases and multi-physics. Its application to stea...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章


    authors: Li H,Wang X,Wang Z,Lam KY

    更新日期:2005-09-16 00:00:00