Abstract:
:pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH-dependent structure change of vesicles was also observed by DLS and TEM. Dox-loaded vesicles exhibit a sharp pH-responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox-resistant MCF-7/adr cells. These results suggest such vesicles based on pH-responsive polyphosphazene hold great potential for specific drug therapy.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Zheng C,Yao X,Qiu Ldoi
10.1002/mabi.201000333subject
Has Abstractpub_date
2011-03-10 00:00:00pages
338-43issue
3eissn
1616-5187issn
1616-5195journal_volume
11pub_type
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