Novel peptide-shelled dendrimer with dramatically changeable thermo-responsive character.

abstract：:It is of paramount importance to study the cellular uptake processes of particles with defined surface property, especially the uptake pathways and intracellular transportation. In this study, aptamer AS1411 molecules, which are known to specifically bind the over-expressed nucleolin on cancer cell membrane, were conj...

journal_title：Macromolecular bioscience

authors： Yu D,Zhang Y,Mao Z,Gao C

更新日期：2013-10-01 00:00:00

abstract：:Implant failure is one of the major concerns in the biomaterials field. Several factors have been related to the fail but in general these biomaterials do not exhibit comparable physical, chemical or biological properties to natural tissues and ultimately, these devices can lead to chronic inflammation and foreign-bod...

journal_title：Macromolecular bioscience

authors： Marques AP,Reis RL,Hunt JA

更新日期：2005-08-12 00:00:00

abstract：:The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equiva...

journal_title：Macromolecular bioscience

authors： Gao SQ,Sun Y,Kopecková P,Peterson CM,Kopecek J

更新日期：2009-11-10 00:00:00

abstract：:An antioxidant microgel with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities is reported. Using computational design and genetic engineering methods, the main catalytic components of GPx are fabricated onto the surface of ferritin. The resulting seleno-ferritin (Se-Fn) monomers can self-ass...

journal_title：Macromolecular bioscience

authors： Gao Y,Hou C,Zhou L,Zhang D,Zhang C,Miao L,Wang L,Dong Z,Luo Q,Liu J

更新日期：2013-06-01 00:00:00

abstract：:Considerable efforts have been devoted to enhancing the cell penetration of nanoparticles by coating cell-penetrating peptides (CPPs) on the surface. However, the internalization mechanism for a CPP at different concentrations varies a lot. It is acknowledged that the mechanism is restricted to endocytic pathway at re...

journal_title：Macromolecular bioscience

authors： Ming Y,Xiao Y,Tian Y,Zhou S

更新日期：2019-04-01 00:00:00

abstract：:We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...

journal_title：Macromolecular bioscience

authors： Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MR

更新日期：2009-09-09 00:00:00

abstract：:Recently, the Foresight Institute has pronounced six economic challenges that can be addressed through the progress of nanotechnology. One of these is the health and longevity of human life. Amongst applications anticipated to provide a solution to this challenge, gene therapy appears to be particularly promising. In ...

journal_title：Macromolecular bioscience

authors： Lamarre B,Ryadnov MG

更新日期：2011-04-08 00:00:00

abstract：:In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

journal_title：Macromolecular bioscience

authors： Fan J,Li Y,Jiang H,Tang G,Wang L

更新日期：2008-05-13 00:00:00

abstract：:Cell adhesion to a scaffold is a prerequisite for tissue engineering. Many studies have been focused on enhancing cell adhesion to synthetic materials that are used for scaffold fabrication. In this study, we applied an avidin-biotin binding system to enhance chondrocyte adhesion to biodegradable polymers. Biotin mole...

journal_title：Macromolecular bioscience

authors： Tsai WB,Wang MC

更新日期：2005-03-15 00:00:00

abstract：:Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and s...

journal_title：Macromolecular bioscience

authors： Upadhyay KK,Bhatt AN,Castro E,Mishra AK,Chuttani K,Dwarakanath BS,Schatz C,Le Meins JF,Misra A,Lecommandoux S

更新日期：2010-05-14 00:00:00

abstract：:Plant derived flavonoids have not been well explored in tissue engineering applications due to difficulties in efficient formulations with biomaterials for controlled presentation. Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L-lactic acid) (P...

journal_title：Macromolecular bioscience

authors： Madhurakkat Perikamana SK,Lee SM,Lee J,Ahmad T,Lee MS,Yang HS,Shin H

更新日期：2019-04-01 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC)-capped poly(methyl methacrylate)-b-polycaprolactone block copolymer (PMMA-b-PCL-NAC) was prepared using the previously described one-pot photoinduced sequential CuAAC/thiol-ene double click procedure. PMMA-b-PCL-NAC had previously shown good applicability as a matrix for cell adhesion of cell...

journal_title：Macromolecular bioscience

authors： Oyman Eyrilmez G,Doran S,Murtezi E,Demir B,Odaci Demirkol D,Coskunol H,Timur S,Yagci Y

更新日期：2015-09-01 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...

journal_title：Macromolecular bioscience

authors： King WJ,Pytel NJ,Ng K,Murphy WL

更新日期：2010-06-11 00:00:00

abstract：:Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...

journal_title：Macromolecular bioscience

authors： Hiraishi T,Masuda E,Kanayama N,Nagata M,Doi Y,Abe H,Maeda M

更新日期：2009-01-09 00:00:00

abstract：:The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...

journal_title：Macromolecular bioscience

authors： Kaihara S,Osanai Y,Nishikawa K,Toshima K,Doi Y,Matsumura S

更新日期：2005-07-14 00:00:00

abstract：:The random copolymer, poly[lactide-co-glycotide-co-(epsilon-caprolactone)] (PLGACL) diacrylate was prepared by ring-opening polymerization of L-lactide, glycolide, and epsilon-caprolactone initiated with tetra(ethylene glycol). The diacrylated polymers were extensively characterized. With a UV embossing method, these ...

journal_title：Macromolecular bioscience

authors： Zhu A,Chen R,Chan-Park MB

更新日期：2006-01-05 00:00:00

abstract：:We report on a novel series of biomimetic polymers exhibiting interfacial properties similar to the extracellular matrix. A series of well-defined surfactant polymers were synthesized by simultaneously incorporating arginine-glycine-aspartic acid (RGD) peptide, dextran oligosaccharide, and hexyl ligands with controlle...

journal_title：Macromolecular bioscience

authors： Anderson EH,Ruegsegger MA,Murugesan G,Kottke-Marchant K,Marchant RE

更新日期：2004-08-09 00:00:00

abstract：:Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage,...

journal_title：Macromolecular bioscience

authors： Vankayala R,Corber SR,Mac JT,Rao MP,Shafie M,Anvari B

更新日期：2018-04-01 00:00:00

abstract：:Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...

journal_title：Macromolecular bioscience

authors： Fukushima K,Furuhashi Y,Sogo K,Miura S,Kimura Y

更新日期：2005-01-14 00:00:00

abstract：:The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance propertie...

journal_title：Macromolecular bioscience

authors： Alavi M,Nokhodchi A

更新日期：2020-04-01 00:00:00

abstract：:Back Cover: The authors have created polymers which release insulin using light. These materials utilize insulin itself as the primary monomer and therefore achieve a very high density (85% w/w insulin). This near perfect density makes them ideal as photoactivated depots of insulin. Further details can be found in the...

journal_title：Macromolecular bioscience

authors： Sarode BR,Jain PK,Friedman SH

更新日期：2016-08-01 00:00:00

abstract：:Aggregation of denatured or unfolded proteins establishes a large energy barrier to spontaneous recovery of protein form and function following traumatic injury, tissue cryopreservation, and biopharmaceutical storage. Some tissues utilize small heat shock proteins (sHSPs) to prevent irreversible aggregation, which all...

journal_title：Macromolecular bioscience

authors： Poellmann MJ,Sosnick TR,Meredith SC,Lee RC

更新日期：2017-02-01 00:00:00

abstract：:A generally applicable strategy to obtain mechanically robust hydrogels for the incorporation and containment of functional reporter bacteria for the microarray and microparticle-based detection and signaling of N-acyl homoserine lactone autoinducers (3OC12 HSL) at relevant concentrations is reported. For reinforcing ...

journal_title：Macromolecular bioscience

authors： Li P,Dou X,Müller M,Feng C,Chang MW,Frettlöh M,Schönherr H

更新日期：2017-11-01 00:00:00

abstract：:Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial c...

journal_title：Macromolecular bioscience

authors： Whittington CF,Yoder MC,Voytik-Harbin SL

更新日期：2013-09-01 00:00:00

abstract：:Novel molecular ecological techniques were used to study changes in microbial community structure and population during degradation of polylactide (PLA)/organically modified layered silicates (OMLS) nanocomposites. Cloned gene sequences belonging to members of the phyla Actinobacteria and Ascomycota comprized the most...

journal_title：Macromolecular bioscience

authors： Sangwan P,Way C,Wu DY

更新日期：2009-07-07 00:00:00

abstract：:Current methods of tissue fixation rely on mechanical-related technologies developed from the clothing and carpentry industries. Herein, a novel bioadhesive method that allows tuneable adhesion and is also applicable to biodegradable polyester substrates is described. Diazirine is the key functional group that allows ...

journal_title：Macromolecular bioscience

authors： Mogal V,Papper V,Chaurasia A,Feng G,Marks R,Steele T

更新日期：2014-04-01 00:00:00

abstract：:A new anhydroribotrisaccharide monomer, A2B3LR (1), was synthesized and ROP was carried out to elucidate the polymerizability and to obtain oligosaccharide-branched polysaccharides with defined structures. The new trisaccharide monomer was found to be polymerized readily with BF(3) . OEt(2) as a catalyst at -40 degree...

journal_title：Macromolecular bioscience

authors： Yoshida D,Han S,Narita K,Hattori K,Yoshida T

更新日期：2009-07-07 00:00:00

abstract：:Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength ...

journal_title：Macromolecular bioscience

authors： Rajkhowa R,Gil ES,Kluge J,Numata K,Wang L,Wang X,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:In order to impart antibacterial properties to microfibrous electrospun materials from styrene/maleic anhydride copolymers, quaternized chitosan derivatives (QCh) containing alkyl substituents of different chain lengths are covalently attached to the mats. A complete inhibition of the growth of bacteria, S. aureus (Gr...

journal_title：Macromolecular bioscience

authors： Ignatova M,Petkova Z,Manolova N,Markova N,Rashkov I

更新日期：2012-01-01 00:00:00