Electroactive Composite of FeCl3 -Doped P3HT/PLGA with Adjustable Electrical Conductivity for Potential Application in Neural Tissue Engineering.

Abstract:

:Conducting polymers (CPs) is one of intelligent biomaterials with the specific properties of reversible redox states, which have a significant effects on the cell behaviors and nerve tissue regeneration. However, the effects of CPs with different electrical conductivity on the behaviors of nerve cells are rarely reported. Therefore, a kind of Poly(3-hexylthiophene) (P3HT) with certain molecular weight is synthesized by Kumada catalyst transfer polymerization (KCTP) method and employed to prepare bioabsorbable and electroactive intelligent composites of Poly(3-hexylthiophene)/Poly(glycolide-lactide) (P3HT/PLGA). FeCl3 doping electroactive membranes with different electrical conductivities are prepared to investigate the cell behaviors. On the substrate with higher electrical conductivity, the proliferation of rat adrenal pheochromocytoma cells (PC12 cells) is significantly promoted and neurite length is increased obviously. In particular, the most significant improvements are the neuron gene expression of Synapsin 1 and microtubule-associated protein 2 (MAP2) by the composites with high conductivity. These results suggest that P3HT/PLGA with suitable electrical conductivity have a positive role in promoting neural growth and differentiation, which is promising for advancing potential application of nerve repair and regeneration.

journal_name

Macromol Biosci

authors

Zhang S,Yan H,Yeh JM,Shi X,Zhang P

doi

10.1002/mabi.201900147

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

e1900147

issue

10

eissn

1616-5187

issn

1616-5195

journal_volume

19

pub_type

杂志文章
  • Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs.

    abstract::Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200471

    authors: Schuurman W,Levett PA,Pot MW,van Weeren PR,Dhert WJ,Hutmacher DW,Melchels FP,Klein TJ,Malda J

    更新日期:2013-05-01 00:00:00

  • Green preparation process, characterization and antitumor effects of doxorubicin-BSA-dextran nanoparticles.

    abstract::In this report, we developed a simple and green process of simultaneous formation of doxorubicin-BSA-dextran nanoparticles in aqueous solution and high-effective encapsulation of doxorubicin. In the presence of BSA-dextran conjugates, which were produced by Maillard reaction, a binding of doxorubicin with BSA can supp...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000125

    authors: Deng W,Li J,Yao P,He F,Huang C

    更新日期:2010-10-08 00:00:00

  • Construction of a hyperbranched supramolecular polymer as a bifunctional antioxidative enzyme model.

    abstract::A HBSP has been designed as a novel bifunctional enzyme model with SOD and GPx activity by host/guest-directed self-assembly of MnTPyP-M-Ad and 6-Te-diCD. The structure of the host/guest complex was elucidated by (1) H NMR spectra, and the HBSP was characterized by SEM, DLS and measurement of catalytic properties. In ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000478

    authors: Yu S,Zhang W,Zhu J,Yin Y,Jin H,Zhou L,Luo Q,Xu J,Liu J

    更新日期:2011-06-14 00:00:00

  • Antimicrobial and Wound Treatment Aspects of Micro- and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO-Oxidized Derivatives of Cellulose: Recent Advances.

    abstract::The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance propertie...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.201900362

    authors: Alavi M,Nokhodchi A

    更新日期:2020-04-01 00:00:00

  • Poly(N-methylvinylamine)-Based Copolymers for Improved Gene Transfection.

    abstract::Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700353

    authors: Dréan M,Debuigne A,Jérôme C,Goncalves C,Midoux P,Rieger J,Guégan P

    更新日期:2018-04-01 00:00:00

  • Adhesion of human U937 monocytes to nitrogen-rich organic thin films: novel insights into the mechanism of cellular adhesion.

    abstract::We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200800359

    authors: Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MR

    更新日期:2009-09-09 00:00:00

  • Imaging Cell-Matrix Interactions in 3D Collagen Hydrogel Culture Systems.

    abstract::3D hydrogels better replicate in vivo conditions, and yield different results from 2D substrates. However, imaging interactions between cells and the hydrogel microenvironment is challenging because of light diffraction and poor focal depth. Here, cryosectioning and vibrating microtomy methods and fixation protocols a...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600478

    authors: Short AR,Czeisler C,Stocker B,Cole S,Otero JJ,Winter JO

    更新日期:2017-06-01 00:00:00

  • Bio-based biodegradable and biocompatible hyperbranched polyurethane: a scaffold for tissue engineering.

    abstract::Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1-5 wt%) as the B(4) reactant with and without the monoglyceride of sunflower oil. The biodegradation, physico-mechanical, and thermal properties are found to be tailored by varying the percentage weight of the branching...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200244

    authors: Das B,Chattopadhyay P,Mandal M,Voit B,Karak N

    更新日期:2013-01-01 00:00:00

  • Poly(polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents.

    abstract::Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600105

    authors: Navarro L,Mogosanu DE,de Jong T,Bakker AD,Schaubroeck D,Luna J,Rintoul I,Vanfleteren J,Dubruel P

    更新日期:2016-11-01 00:00:00

  • Stabilization of gelatin nanoparticles without crosslinking.

    abstract::Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176 nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2%...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201400214

    authors: Khan SA,Schneider M

    更新日期:2014-11-01 00:00:00

  • Novel polymeric vesicles with pH-induced deformation character for advanced drug delivery.

    abstract::pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lip...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000333

    authors: Zheng C,Yao X,Qiu L

    更新日期:2011-03-10 00:00:00

  • Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface.

    abstract::PCL microspheres featuring a macroporous morphology and a bone-bioactive surface have been prepared. 'Camphene' was introduced to generate pores within the microsphere network. The pore size was variable from a few to tens to hundreds of microm depending on the Camphene/PCL ratio. Macropores (with sizes >50 microm) co...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200800304

    authors: Hong SJ,Yu HS,Kim HW

    更新日期:2009-07-07 00:00:00

  • Biological natural retting for determining the hierarchical structuration of banana fibers.

    abstract::Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200400041

    authors: Gañán P,Zuluaga R,Velez JM,Mondragon I

    更新日期:2004-10-20 00:00:00

  • Innovative Methods and Applications in Mucoadhesion Research.

    abstract::The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus des...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.201600534

    authors: Mackie AR,Goycoolea FM,Menchicchi B,Caramella CM,Saporito F,Lee S,Stephansen K,Chronakis IS,Hiorth M,Adamczak M,Waldner M,Nielsen HM,Marcelloni L

    更新日期:2017-08-01 00:00:00

  • Hydrophilic core-shell microspheres: a suitable support for controlled attachment of proteins and biomedical diagnostics.

    abstract::Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.200500138

    authors: Basinska T

    更新日期:2005-12-15 00:00:00

  • Fluoropolymer based on a polyaspartamide containing 1,2,4-oxadiazole units: a potential artificial oxygen (O2) carrier.

    abstract::In this preliminary work we have prepared a fluorinated polymer capable of solubilizing an appreciable amount of O(2) and, at the same time, maintaining a higher water solubility than perfluoroalkanes investigated as injectable O(2) carriers. In particular, we describe the synthesis and characterization of a new macro...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200600266

    authors: Mandracchia D,Piccionello AP,Pitarresi G,Pace A,Buscemi S,Giammona G

    更新日期:2007-06-07 00:00:00

  • Thermohydrogel Containing Melanin for Photothermal Cancer Therapy.

    abstract::Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600371

    authors: Kim M,Kim HS,Kim MA,Ryu H,Jeong HJ,Lee CM

    更新日期:2017-05-01 00:00:00

  • Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability.

    abstract::Aggregation is frequently encountered during coating nanoparticles, especially when the core is not solid and the coating polyelectrolytes are weak. Here, the coating of a nanoliposome with two weak polyelectrolytes, alginate and chitosan, is investigated. First, quartz crystal microbalance with dissipation, atomic fo...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600535

    authors: Nayef L,Castiello R,Tabrizian M

    更新日期:2017-06-01 00:00:00

  • Conductive hydrogels: mechanically robust hybrids for use as biomaterials.

    abstract::A hybrid system for producing conducting polymers within a doping hydrogel mesh is presented. These conductive hydrogels demonstrate comparable electroactivity to conventional conducting polymers without requiring the need for mobile doping ions which are typically used in literature. These hybrids have superior mecha...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201100490

    authors: Green RA,Hassarati RT,Goding JA,Baek S,Lovell NH,Martens PJ,Poole-Warren LA

    更新日期:2012-04-01 00:00:00

  • Comb-shaped glycopolymer/peptide bioconjugates by combination of RAFT polymerization and thiol-ene "click" chemistry.

    abstract::Comb-shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate-functional block glycocopolymers via thiol-ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self-assembles to sugar-installed spherical micelles. The size of micelles decreases ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200274

    authors: Wang X,Liu L,Luo Y,Shi H,Li J,Zhao H

    更新日期:2012-11-01 00:00:00

  • Molecular Mechanism Study on Effect of Biodegradable Amino Acid Ester-Substituted Polyphosphazenes in Stimulating Osteogenic Differentiation.

    abstract::Amino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus-containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3 (ethyl glycinato)0.7 phosphazene] (PAG...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201800464

    authors: Huang Z,Yang L,Hu X,Huang Y,Cai Q,Ao Y,Yang X

    更新日期:2019-06-01 00:00:00

  • Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration.

    abstract::A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200700053

    authors: Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

    更新日期:2007-11-12 00:00:00

  • A highly efficient siRNA carrier of PBLG modified hyperbranched PEI.

    abstract::In search for effective non-viral gene vectors for the delivery of siRNA, a copolymer was designed and synthesized by grafting hydrophobic poly(gamma-benzyl L-glutamate) segment (PBLG) to hyperbranched polyethylenimine (PEI-PBLG). PEI-PBLG could efficiently deliver siRNA to cells to silence the targeted gene. Markedly...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200900249

    authors: Chen J,Tian H,Guo Z,Xia J,Kano A,Maruyama A,Jing X,Chen X

    更新日期:2009-12-08 00:00:00

  • Multifunctional Sutures with Temperature Sensing and Infection Control.

    abstract::The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.202000364

    authors: Houshyar S,Bhattacharyya A,Khalid A,Rifai A,Dekiwadia C,Kumar GS,Tran PA,Fox K

    更新日期:2021-01-12 00:00:00

  • Nanofibers for Biomedical and Healthcare Applications.

    abstract::Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrica...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.201800256

    authors: Rasouli R,Barhoum A,Bechelany M,Dufresne A

    更新日期:2019-02-01 00:00:00

  • Development, Validation, and Performance of Chitosan-Based Coatings Using Catechol Coupling.

    abstract::The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201900253

    authors: Souza Campelo C,Chevallier P,Loy C,Silveira Vieira R,Mantovani D

    更新日期:2020-01-01 00:00:00

  • Solvent-responsive behavior of inclusion complexes between amylose and polytetrahydrofuran.

    abstract::Highly crystalline amylose-polytetrahydrofuran (PTHF) complexes can be obtained by employing organic solvents as washing agents after complex formation. The X-ray diffraction (XRD) of the washed complexes appear sharp at 12.9°-13.2° and 19.6°-20.1°, clear signs of the presence of V6I -amylose. Other diffraction peaks ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201300174

    authors: Rachmawati R,Woortman AJ,Loos K

    更新日期:2014-01-01 00:00:00

  • Preparation of a novel polymer-modified si surface for DNA immobilization.

    abstract::The design of a novel polymer-modified overlayer composed of PPAPE and GPMS on a silicon wafer for immobilization of DNA molecules is described. After hydroxylation of Si(100) surfaces, GPMS molecules were self-assembled onto these surfaces. PPAPE molecules were then covalently attached to the epoxy-terminated surface...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200800226

    authors: Demirel GB,Coşkun S,Kalkan M,Caykara T

    更新日期:2009-05-13 00:00:00

  • Rational Design of a Conductive Collagen Heart Patch.

    abstract::Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly im...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201600446

    authors: Sherrell PC,Cieślar-Pobuda A,Ejneby MS,Sammalisto L,Gelmi A,de Muinck E,Brask J,Łos MJ,Rafat M

    更新日期:2017-07-01 00:00:00

  • Polymersomes from polypeptide containing triblock Co- and terpolymers for drug delivery against pancreatic cancer: asymmetry of the external hydrophilic blocks.

    abstract::Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(γ-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two polymers exhibit similar PBLG(-d7) composition, while in the ABC, the volume fraction of PEO block is ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201400137

    authors: Iatrou H,Dimas K,Gkikas M,Tsimblouli C,Sofianopoulou S

    更新日期:2014-09-01 00:00:00