Abstract:
:The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new multifunctional suture with such capabilities. Incorporation of FND and rGO into PCL enhances its tensile strength by about 43% and toughness by 35%. The sutures show temperature sensing capability in the range of 25-40 °C based on the shift in zero-splitting frequency of the nitrogen-vacancy (NV- ) centers in FND via optically detected magnetic resonance, paving the way for potential detection of infection or excessive inflammation in healing wounds. The suture surface readily coats with antibiotics to reduce bacterial infection risk to the wounds. The new suture thus is promising in monitoring and supporting wound closure.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Houshyar S,Bhattacharyya A,Khalid A,Rifai A,Dekiwadia C,Kumar GS,Tran PA,Fox Kdoi
10.1002/mabi.202000364subject
Has Abstractpub_date
2021-01-12 00:00:00pages
e2000364eissn
1616-5187issn
1616-5195pub_type
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