Abstract:
:Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer structures have a profound impact on bacterial adhesion. Thus, line- and pillar-like patterns enhanced S. aureus adhesion, whereas complex lamella microtopography reduced S. aureus adhesion in static and continuous flow culture conditions. Interestingly, lamella-like textured surfaces retained the capacity to inhibit S. aureus adhesion both when the surface is coated with human serum proteins and when the material is implanted subcutaneously in a foreign-body associated infection model.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Valle J,Burgui S,Langheinrich D,Gil C,Solano C,Toledo-Arana A,Helbig R,Lasagni A,Lasa Idoi
10.1002/mabi.201500107subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1060-9issue
8eissn
1616-5187issn
1616-5195journal_volume
15pub_type
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