Abstract:
:[Image: see text] Oligosaccharides at cell surfaces are known to play a critical role in many biological processes such as biorecognition, interactions between cells and with artificial surfaces, immune response, infection and inflammation. In order to facilitate studies of the role of sugars, an increasing number of novel tools are becoming available. New synthetic strategies now provide much more efficient access to complex carbohydrates or glycoconjugates. Branched carbohydrates and hybrids of carbohydrates conjugated to polymers have been prepared using solution and/or solid-phase synthesis and advanced methods of polymerization. These materials are essential for the development of methodologies to study and map the molecular structure-function relationship at interfaces. This article highlights recent advances in the synthesis of carbohydrates and polymer hybrids mimicking the properties and functionalities of the natural oligosaccharides, as well as selected applications in biology, biotechnology and diagnostics.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Coullerez G,Seeberger PH,Textor Mdoi
10.1002/mabi.200600090subject
Has Abstractpub_date
2006-08-07 00:00:00pages
634-47issue
8eissn
1616-5187issn
1616-5195journal_volume
6pub_type
杂志文章abstract::Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Micro...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200317
更新日期:2013-03-01 00:00:00
abstract::Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300055
更新日期:2004-04-19 00:00:00
abstract::Multicellular tumor spheroid (MCTS) mimics microenvironment for tumor formation and provides predictive insight for in vivo tests. The hanging drop (HD) method of spheroid generation is cost effective, but it is limited by a long time duration for spheroid development and a low rate of formation of larger spheroids. T...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000180
更新日期:2020-08-01 00:00:00
abstract::The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400122
更新日期:2014-09-01 00:00:00
abstract::In many industrial applications, inadequate cell attachment can be a limitation, especially when serum-free media are used. Nitrogen-rich plasma-polymerised ethylene (PPE:N) exhibits high concentrations of polar groups that can help to promote the attachment of weakly adherent cell types. Tissue plasminogen activator-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900079
更新日期:2009-10-08 00:00:00
abstract::Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200471
更新日期:2013-05-01 00:00:00
abstract::Hydroxypropyl chitosan-graft-carboxymethyl beta-cyclodextrin (HPCH-g-CM beta-CD) was synthesized by grafting CM beta-CD onto HPCH using water soluble 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as the condensing agent. Due to the presence of hydrophobic beta-CD rings onto the HPCH backbone, this polymer can be...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500087
更新日期:2005-10-20 00:00:00
abstract::The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is succe...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100457
更新日期:2012-05-01 00:00:00
abstract::The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000364
更新日期:2021-01-12 00:00:00
abstract::Three types of multilayer films made from poly(L-lysine)/hyaluronan, chitosan/hyaluronan, and poly(allylamine hydrochloride)/poly(L-glutamic acid), were used to investigate the interplay between film mechano-chemical properties and cell adhesion. We showed that C2C12 myoblast adhesion and proliferation depended on the...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000301
更新日期:2011-01-10 00:00:00
abstract::Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201700209
更新日期:2018-01-01 00:00:00
abstract::Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000153
更新日期:2020-08-01 00:00:00
abstract::The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700299
更新日期:2018-02-01 00:00:00
abstract::Stereolithography-assisted fabrication of hydrogels of carboxybetaine methacrylamide (CBMAA) and a α,ω-methacrylate poly(d,l-lactide-block-ethylene glycol-block- d,l-lactide) (MA-PDLLA-PEG-PDLLA-MA) telechelic triblock macromer is presented. This technique allows printing complex structures with gyroid interconnected ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800403
更新日期:2019-04-01 00:00:00
abstract::Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage,...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700379
更新日期:2018-04-01 00:00:00
abstract::Amino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus-containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3 (ethyl glycinato)0.7 phosphazene] (PAG...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800464
更新日期:2019-06-01 00:00:00
abstract::The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance propertie...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201900362
更新日期:2020-04-01 00:00:00
abstract::The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacit...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200346
更新日期:2013-04-01 00:00:00
abstract::Two different composite scaffolds, solid-freeform-fabricated PCL/β-TCP supplemented with and without collagen nanofibers are fabricated. These scaffolds are evaluated whether a combination of collagen nanofibers with PCL/β-TCP can promote osteogenesis in a mastoid obliteration. To assess the effects of the cellular ac...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200393
更新日期:2013-05-01 00:00:00
abstract::Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. In recent years, MB have also attracted interest as drug delivery systems. Soft-shelled lipidic MB tend to be more advantageous for US imaging, while hard-shelled polymeric MB appear to be more suitable for drug delivery purposes beca...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700002
更新日期:2017-10-01 00:00:00
abstract::Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700353
更新日期:2018-04-01 00:00:00
abstract::The aggregative behaviors of hydroxypropylcellulose (HPC) molecules in aqueous solution and on substrates have been observed by employing laser light scattering (LLS) and, after deposition on a mica surface, atomic force microscopy (AFM). LLS studies showed that the HPC molecules formed large aggregates through self-a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600067
更新日期:2006-07-14 00:00:00
abstract::Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer stru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500107
更新日期:2015-08-01 00:00:00
abstract::Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200143
更新日期:2012-10-01 00:00:00
abstract::Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into sc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700141
更新日期:2017-11-01 00:00:00
abstract::Solution-grown chain-folded lamellar single crystals of poly(tetramethylene adipate) (PTMA) were prepared from a dilute solution of 2-methyl-1-propanol by isothermal crystallization. PTMA crystals were hexagonal-shaped and polyethylene decoration of the crystals resulted in a "six cross-sector" surface morphology and ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300086
更新日期:2004-03-15 00:00:00
abstract::An electroactive amino/carboxyl-capped aniline tetramer (AT) is covalently grafted to the surface of hydroxyapatite (HA) nanoparticles to generate novel electroactive HA-AT nanoparticles. The amount of AT ranges from 16.5 to 34.0 wt% and is characterized by thermogravimetric analysis (TGA). The HA-AT nanoparticles are...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200345
更新日期:2013-03-01 00:00:00
abstract::The present study investigates the effect of galactosylated gelatin on encapsulated HepG2 cells. Methacrylamide modified gelatin is evaluated and compared with its galactosylated counterpart with respect to effects on viability, morphological characteristics, proliferation, and the expression of hepatocyte specific ma...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300320
更新日期:2014-03-01 00:00:00
abstract::In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900382
更新日期:2010-06-11 00:00:00
abstract::An insoluble wheat proteins-based polymer networks with new functional groups and positive charges were prepared through grafting-coupling reactions. The networks were also flexible with a lower glass transition temperature since the existence of the grafted mobile segments. The multi-component/multi-phase systems bec...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800156
更新日期:2009-01-09 00:00:00