Abstract:
:Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Microscopy studies of the prepared materials showed nanostructured fibrous collagen and cellulose dispersed in collagen matrix. Mechanical performance of the sterilized nanocomposites was close to that of natural ligament and tendon, in simulated body conditions. Cytocompatibility studies indicated that these nanocomposites allowed human ligament cell and human endothelial cell adhesion, growth, and differentiation; which is eminently favourable to ligament tissue engineering.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Mathew AP,Oksman K,Pierron D,Harmand MFdoi
10.1002/mabi.201200317subject
Has Abstractpub_date
2013-03-01 00:00:00pages
289-98issue
3eissn
1616-5187issn
1616-5195journal_volume
13pub_type
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