Abstract:
:Novel water-insoluble, and reduction-responsive nonwoven scaffolds were fabricated from gamma-PGA and tested in cell culture. An electrospinning method was developed to produce scaffolds of fibers with diameters of 0.05-0.5 microm. Crosslinking of the fibers with cystamine in the presence of EDC resulted in water-insoluble gamma-PGA nonwovens with disulfide crosslinkages. These crosslinked fibers were easily decomposed under physiological conditions using L-cysteine, a biocompatible reductant. In vitro experiments with mouse L929 fibroblasts showed good adhesion onto gamma-PGA-SS fiber matrices and excellent cell proliferation. These gamma-PGA-SS nonwovens can be used as novel biocompatible and biodegradable scaffolds with reduction-responsiveness for biomedical or tissue engineering applications.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Yoshida H,Klinkhammer K,Matsusaki M,Möller M,Klee D,Akashi Mdoi
10.1002/mabi.200800334subject
Has Abstractpub_date
2009-06-11 00:00:00pages
568-74issue
6eissn
1616-5187issn
1616-5195journal_volume
9pub_type
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