Photo-crosslinked biodegradable hydrogels prepared from fumaric acid monoethyl ester-functionalized oligomers for protein delivery.

Abstract:

:Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo-polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.

journal_name

Macromol Biosci

authors

Jansen J,Mihov G,Feijen J,Grijpma DW

doi

10.1002/mabi.201100468

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

692-702

issue

5

eissn

1616-5187

issn

1616-5195

journal_volume

12

pub_type

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