Abstract:
:Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo-polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Jansen J,Mihov G,Feijen J,Grijpma DWdoi
10.1002/mabi.201100468subject
Has Abstractpub_date
2012-05-01 00:00:00pages
692-702issue
5eissn
1616-5187issn
1616-5195journal_volume
12pub_type
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