Study of the selective uptake progress of aptamer-modified PLGA particles by liver cells.

abstract：:Microbial transglutaminase (mTG) and mushroom tyrosinase (MT) are used to crosslink B. mori silk fibroin/gelatin (SF/G) films. Crosslinked and uncrosslinked SF/G films show no phase separation. The thermal behavior and the conformational structure of SF/G films are strongly affected by blending and enzymatic treatment...

journal_title：Macromolecular bioscience

authors： Taddei P,Chiono V,Anghileri A,Vozzi G,Freddi G,Ciardelli G

更新日期：2013-11-01 00:00:00

abstract：:Previously synthesized amphiphilic diblock copolymers with pendant dendron moieties have been investigated for their potential use as drug carriers to improve the delivery of an anticancer drug to human breast cancer cells. Diblock copolymer (P71 D3 )-based micelles effectively encapsulate the doxorubicin (DOX) with a...

journal_title：Macromolecular bioscience

authors： Viswanathan G,Hsu YH,Voon SH,Imae T,Siriviriyanun A,Lee HB,Kiew LV,Chung LY,Yusa S

更新日期：2016-06-01 00:00:00

abstract：:Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...

journal_title：Macromolecular bioscience

authors： Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth T

更新日期：2012-06-01 00:00:00

abstract：:A combination of hard sphere and high internal phase emulsion templating gives a platform for synthesizing hierarchically porous polymers with a unique topology exhibiting interconnected spherical features on multiple levels. Polymeric spheres are fused by thermal sintering to create a 3D monolithic structure while an...

journal_title：Macromolecular bioscience

authors： Paljevac M,Gradišnik L,Lipovšek S,Maver U,Kotek J,Krajnc P

更新日期：2018-02-01 00:00:00

abstract：:Thermosensitive macroporous scaffolds of poly(N-isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin nanoparticles of 102 ± 6.5 nm diameter are prepared by complex coacervation and loaded into polyNIPA c...

journal_title：Macromolecular bioscience

authors： Peniche H,Reyes-Ortega F,Aguilar MR,Rodríguez G,Abradelo C,García-Fernández L,Peniche C,San Román J

更新日期：2013-11-01 00:00:00

abstract：:Development of artificial tissues providing the proper geometrical, mechanical, and environmental cues for cells is highly coveted in the field of tissue engineering. Recently, microfabrication strategies in combination with other chemistries have been utilized to capture the architectural complexity of intricate orga...

journal_title：Macromolecular bioscience

authors： Kim MH,Kumar SK,Shirahama H,Seo J,Lee JH,Zhdanov VP,Cho NJ

更新日期：2016-03-01 00:00:00

abstract：:In search for effective non-viral gene vectors for the delivery of siRNA, a copolymer was designed and synthesized by grafting hydrophobic poly(gamma-benzyl L-glutamate) segment (PBLG) to hyperbranched polyethylenimine (PEI-PBLG). PEI-PBLG could efficiently deliver siRNA to cells to silence the targeted gene. Markedly...

journal_title：Macromolecular bioscience

authors： Chen J,Tian H,Guo Z,Xia J,Kano A,Maruyama A,Jing X,Chen X

更新日期：2009-12-08 00:00:00

abstract：:Three types of multilayer films made from poly(L-lysine)/hyaluronan, chitosan/hyaluronan, and poly(allylamine hydrochloride)/poly(L-glutamic acid), were used to investigate the interplay between film mechano-chemical properties and cell adhesion. We showed that C2C12 myoblast adhesion and proliferation depended on the...

journal_title：Macromolecular bioscience

authors： Boudou T,Crouzier T,Nicolas C,Ren K,Picart C

更新日期：2011-01-10 00:00:00

abstract：:O-carboxymethylchitin (molecular weight = 1.07 x 10(5), degree of carboxymethylation = 80%, degree of N-acetylation = 91%) was chemically attached to superoxide dismutase by the formation of amide linkages through a carbodiimide catalyzed reaction. The glycosidated enzyme contained about 1.8 mole of polysaccharide per...

journal_title：Macromolecular bioscience

authors： Valdivia A,Perez Y,Dominguez A,Caballero J,Gomez L,Schacht EH,Villalonga R

更新日期：2005-02-23 00:00:00

abstract：:Implant failure is one of the major concerns in the biomaterials field. Several factors have been related to the fail but in general these biomaterials do not exhibit comparable physical, chemical or biological properties to natural tissues and ultimately, these devices can lead to chronic inflammation and foreign-bod...

journal_title：Macromolecular bioscience

authors： Marques AP,Reis RL,Hunt JA

更新日期：2005-08-12 00:00:00

abstract：:Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many n...

journal_title：Macromolecular bioscience

authors： Jacobsen MM,Tokareva OS,Ebrahimi D,Huang W,Ling S,Dinjaski N,Li D,Simon M,Staii C,Buehler MJ,Kaplan DL,Wong JY

更新日期：2017-09-01 00:00:00

abstract：:The use of PLA and PLA-g-AA/starch as materials for the controlled release of encapsulated PSB was evaluated. The results showed that the bacterium degraded both the PLA and the PLA-g-AA/starch composite films, resulting in cell release. Severe disruption of the film structure occurred after incubation for 60-90 d. Th...

journal_title：Macromolecular bioscience

authors： Wu CS

更新日期：2008-06-11 00:00:00

abstract：:Fluorescent dye labeled unfunctionalized and functionalized poly(n-butylcyanoacrylate) nanoparticles were prepared using a miniemulsion technique. Amino acid and methoxyPEG functionalization could be introduced by using aqueous solutions as an initiator for the anionic polymerization in the heterophase. All the partic...

journal_title：Macromolecular bioscience

authors： Weiss CK,Lorenz MR,Landfester K,Mailänder V

更新日期：2007-07-09 00:00:00

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is succe...

journal_title：Macromolecular bioscience

authors： Baldassarre F,Vergaro V,Scarlino F,De Santis F,Lucarelli G,Torre AD,Ciccarella G,Rinaldi R,Giannelli G,Leporatti S

更新日期：2012-05-01 00:00:00

abstract：:Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Micro...

journal_title：Macromolecular bioscience

authors： Mathew AP,Oksman K,Pierron D,Harmand MF

更新日期：2013-03-01 00:00:00

abstract：:Amino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus-containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3 (ethyl glycinato)0.7 phosphazene] (PAG...

journal_title：Macromolecular bioscience

authors： Huang Z,Yang L,Hu X,Huang Y,Cai Q,Ao Y,Yang X

更新日期：2019-06-01 00:00:00

abstract：:To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet a...

journal_title：Macromolecular bioscience

authors： Nagahama K,Ohya Y,Ouchi T

更新日期：2006-06-16 00:00:00

abstract：:Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl ...

journal_title：Macromolecular bioscience

authors： Koschella A,Inngjerdingen K,Paulsen BS,Morris GA,Harding SE,Heinze T

更新日期：2008-01-09 00:00:00

abstract：:The phase behavior of a water/hydroxypropyl cellulose/maleic acid-styrene copolymer (H2O/HPC/MAc-S) system was investigated in the semi-dilute range by turbidimetry, rheology, and optical microscopy. The two polymers under investigation form interpolymer complexes via hydrogen bonding. In the case of a total polymer c...

journal_title：Macromolecular bioscience

authors： Bumbu GG,Eckelt J,Wolf BA,Vasile C

更新日期：2005-10-20 00:00:00

abstract：:A simple continuous flow wet-spinning method to achieve mechanical reinforcement of the two oppositely charged biopolymers chitosan and gellan gum is described. The mechanical properties of these biopolymers are influenced by the order of addition. Using a facile method for mechanical reinforcement of gellan gum/chito...

journal_title：Macromolecular bioscience

authors： Granero AJ,Razal JM,Wallace GG,in het Panhuis M

更新日期：2009-04-08 00:00:00

abstract：:The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...

journal_title：Macromolecular bioscience

authors： Souza Campelo C,Chevallier P,Loy C,Silveira Vieira R,Mantovani D

更新日期：2020-01-01 00:00:00

abstract：:Injectable hydrogels are extensively used in drug delivery and tissue engineering to administer drugs, genes, growth factors and live cells. We report a method to produce tough, in-situ thermogelling, non-toxic, injectable hydrogels made of chitosan and hyaluronic acid co-crosslinked with β-glycerophophate and genipin...

journal_title：Macromolecular bioscience

authors： Jalani G,Rosenzweig DH,Makhoul G,Abdalla S,Cecere R,Vetrone F,Haglund L,Cerruti M

更新日期：2015-04-01 00:00:00

abstract：:In drug delivery to the human brain, blood vessels are a significant hurdle because they restrict the entry of most solutes to protect brain. To overcome this hurdle, an in vitro 3D model for brain endothelial barrier is developed using a microfluidic device with hydrogel providing a 3D extracellular matrix scaffold. ...

journal_title：Macromolecular bioscience

authors： Chung B,Kim J,Nam J,Kim H,Jeong Y,Liu HW,Cho Y,Kim YH,Oh HJ,Chung S

更新日期：2020-06-01 00:00:00

abstract：:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

journal_title：Macromolecular bioscience

authors： Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

更新日期：2007-11-12 00:00:00

abstract：:Cell adhesion to a scaffold is a prerequisite for tissue engineering. Many studies have been focused on enhancing cell adhesion to synthetic materials that are used for scaffold fabrication. In this study, we applied an avidin-biotin binding system to enhance chondrocyte adhesion to biodegradable polymers. Biotin mole...

journal_title：Macromolecular bioscience

authors： Tsai WB,Wang MC

更新日期：2005-03-15 00:00:00

abstract：:Open-pore biodegradable foams with controlled porous architectures were prepared by combining gas foaming and microparticulate templating. Microparticulate composites of poly(epsilon-caprolactone) (PCL) and micrometric sodium chloride particles (NaCl), in concentrations ranging from 70/30 to 20/80 wt.-% of PCL/NaCl we...

journal_title：Macromolecular bioscience

authors： Salerno A,Iannace S,Netti PA

更新日期：2008-07-07 00:00:00

abstract：:Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...

journal_title：Macromolecular bioscience

authors： Chytil P,Koziolová E,Etrych T,Ulbrich K

更新日期：2018-01-01 00:00:00

abstract：:Biopolymers are an attractive class of compounds for being used in biomedical applications as they are widely available from biomass. Their drawback is the lack of mechanical stability and the ability to tune this properly. Covalent chemical cross-linking is an often used approach but it limits usability due to legisl...

journal_title：Macromolecular bioscience

authors： Kühn PT,Meijer TL,Schiavon I,van Poll M,van Aken J,Groen S,Kuijer R,van Kooten TG,van Rijn P

更新日期：2016-11-01 00:00:00

abstract：:Novel molecular ecological techniques were used to study changes in microbial community structure and population during degradation of polylactide (PLA)/organically modified layered silicates (OMLS) nanocomposites. Cloned gene sequences belonging to members of the phyla Actinobacteria and Ascomycota comprized the most...

journal_title：Macromolecular bioscience

authors： Sangwan P,Way C,Wu DY

更新日期：2009-07-07 00:00:00