Abstract:
:It is of paramount importance to study the cellular uptake processes of particles with defined surface property, especially the uptake pathways and intracellular transportation. In this study, aptamer AS1411 molecules, which are known to specifically bind the over-expressed nucleolin on cancer cell membrane, were conjugated onto bovine serum albumin-decorated poly(D,L-lactide-co-glycolide; PLGA, Φ400 nm) particles with a density of 1-1.7 molecule/10 nm(2). The aptamer-modified PLGA particles were preferably ingested by liver cancer cells with higher amount and faster rate. The clathrin-mediated endocytosis and macropinocytosis pathways played a more important role in uptake of the aptamer modified particles.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Yu D,Zhang Y,Mao Z,Gao Cdoi
10.1002/mabi.201300165subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1413-21issue
10eissn
1616-5187issn
1616-5195journal_volume
13pub_type
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