Abstract:
:High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can be varied by adjusting the copolymer composition. The PETA-containing (co)polymer networks are not cytotoxic. Upon incubation in macrophage cultures for 14 d, all (co)polymer films and PETA-containing network films erode to varying extents, showing that these materials can be degraded by cell-mediated erosion processes. This method is very useful for the facile preparation of TMC- and DLLA-containing form-stable networks from high-molecular-weight polymers.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Bat E,van Kooten TG,Feijen J,Grijpma DWdoi
10.1002/mabi.201100031subject
Has Abstractpub_date
2011-07-07 00:00:00pages
952-61issue
7eissn
1616-5187issn
1616-5195journal_volume
11pub_type
杂志文章abstract::Multicellular tumor spheroid (MCTS) mimics microenvironment for tumor formation and provides predictive insight for in vivo tests. The hanging drop (HD) method of spheroid generation is cost effective, but it is limited by a long time duration for spheroid development and a low rate of formation of larger spheroids. T...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000180
更新日期:2020-08-01 00:00:00
abstract::Peptide dendrimers assembled by solid-phase peptide synthesis using a branching diamino acid at every 2(nd) or 3(rd) position provide readily accessible synthetic model systems for proteins and enzymes. They adopt a globular shape by topology rather than by folding. Peptide dendrimers of 2(nd) and 3(rd) generation fun...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700036
更新日期:2007-08-07 00:00:00
abstract::Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200800284
更新日期:2009-02-11 00:00:00
abstract::This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spheric...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800094
更新日期:2018-10-01 00:00:00
abstract::The core-shell micelles in aqueous solutions were prepared at low CAC values (<0.1 mg · mL(-1) ) from amphiphilic graft copolymers consisting of poly(methyl methacrylate) backbone (120-165 units) with loosely grafted (17-40%) hydroxyl-capped PEG (9 vs 6 units in side chain) for drug loading. Hydrophobic indomethacin (...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500189
更新日期:2015-11-01 00:00:00
abstract::Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400238
更新日期:2015-03-01 00:00:00
abstract::A microfluidic technique is described to encapsulate living cells in alginate hydrogel microparticles generated from monodisperse double-emulsion templates. A microcapillary device is used to fabricate double emulsion templates composed of an alginate drop surrounded by a mineral oil shell. Hydrogel formation begins w...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100351
更新日期:2012-07-01 00:00:00
abstract::Stereolithography-assisted fabrication of hydrogels of carboxybetaine methacrylamide (CBMAA) and a α,ω-methacrylate poly(d,l-lactide-block-ethylene glycol-block- d,l-lactide) (MA-PDLLA-PEG-PDLLA-MA) telechelic triblock macromer is presented. This technique allows printing complex structures with gyroid interconnected ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800403
更新日期:2019-04-01 00:00:00
abstract::Since the early 1980s, research on the modification of bone implant surfaces by applying coatings has mainly focused on the application of inorganic calcium phosphate (CaP) coatings using physical deposition techniques. Organic components of the extracellular bone matrix, on the other hand, play an essential role in t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201000142
更新日期:2010-11-10 00:00:00
abstract::[Image: see text] Oligosaccharides at cell surfaces are known to play a critical role in many biological processes such as biorecognition, interactions between cells and with artificial surfaces, immune response, infection and inflammation. In order to facilitate studies of the role of sugars, an increasing number of ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600090
更新日期:2006-08-07 00:00:00
abstract::The material surface must be considered in the design of scaffolds for bone tissue engineering so that it supports bone cells adhesion, proliferation and differentiation. A biomimetic approach has been developed as a 3D surface modification technique to grow partially carbonated hydroxyapatite (the bonelike mineral) i...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300017
更新日期:2004-02-20 00:00:00
abstract::The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducibl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600051
更新日期:2016-11-01 00:00:00
abstract::In this work, it is first reported that the poly (3-hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one-step ring-opening polymerization of β-butyrolactone and extra...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800432
更新日期:2019-05-01 00:00:00
abstract::Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300055
更新日期:2004-04-19 00:00:00
abstract::When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and q...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200092
更新日期:2012-08-01 00:00:00
abstract::The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equiva...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900147
更新日期:2009-11-10 00:00:00
abstract::A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create sin...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200004
更新日期:2012-06-01 00:00:00
abstract::Open-pore biodegradable foams with controlled porous architectures were prepared by combining gas foaming and microparticulate templating. Microparticulate composites of poly(epsilon-caprolactone) (PCL) and micrometric sodium chloride particles (NaCl), in concentrations ranging from 70/30 to 20/80 wt.-% of PCL/NaCl we...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700278
更新日期:2008-07-07 00:00:00
abstract::Injectable hydrogels are extensively used in drug delivery and tissue engineering to administer drugs, genes, growth factors and live cells. We report a method to produce tough, in-situ thermogelling, non-toxic, injectable hydrogels made of chitosan and hyaluronic acid co-crosslinked with β-glycerophophate and genipin...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400406
更新日期:2015-04-01 00:00:00
abstract::To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with inc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600256
更新日期:2007-05-10 00:00:00
abstract::In this study we formed and characterized dynamic hydrogel microspheres in which a protein conformational change was used to control microsphere volume changes and the release of an encapsulated drug. In particular, a specific biochemical ligand, trifluoperazine, induced calmodulin's nanometer scale conformation chang...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900382
更新日期:2010-06-11 00:00:00
abstract::Biopolymers are an attractive class of compounds for being used in biomedical applications as they are widely available from biomass. Their drawback is the lack of mechanical stability and the ability to tune this properly. Covalent chemical cross-linking is an often used approach but it limits usability due to legisl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600214
更新日期:2016-11-01 00:00:00
abstract::The aim of this study is to design a novel two-component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin-based dermal scaffold more robust for the treatment of the clinically challenging pres...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700185
更新日期:2017-11-01 00:00:00
abstract::Emphasizing the role of hydrogel stiffness and cellular differentiation, this study develops collagen and elastin-like polypeptide (ELP)-based bone regenerative hydrogels loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) and doxycycline with mechanical properties suitable for osteogenesis. The drug-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900142
更新日期:2019-09-01 00:00:00
abstract::Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800019
更新日期:2018-07-01 00:00:00
abstract::A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400149
更新日期:2014-10-01 00:00:00
abstract::Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, m...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600165
更新日期:2006-12-08 00:00:00
abstract::Tissue adhesives are an attractive class of biomaterials, which can serve as a treatment for meniscus tears. In this study, physicochemical and adhesive properties of novel biodegradable three-armed- and hyperbranched block copolymeric adhesives are evaluated. Additionally, their degradation in vitro and in vivo, and ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700125
更新日期:2017-11-01 00:00:00
abstract::Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS inc...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100518
更新日期:2012-06-01 00:00:00
abstract::A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400176
更新日期:2005-04-19 00:00:00