Abstract:
:Tissue adhesives are an attractive class of biomaterials, which can serve as a treatment for meniscus tears. In this study, physicochemical and adhesive properties of novel biodegradable three-armed- and hyperbranched block copolymeric adhesives are evaluated. Additionally, their degradation in vitro and in vivo, and the tissue reaction after subcutaneous injection in rats are assessed. The developed adhesives have sufficient adhesive strength to meniscus tissue after curing (66-88 kPa). Networks based on the three-armed adhesive have tensile properties that are in the same range as human meniscus. After 26 weeks, networks based on the hyperbranched adhesive show a faster mass loss (25.4%) compared to networks prepared from the three-armed ones (5.5%). Both adhesives induce an inflammatory reaction, however, no necrosis and only initial toxic effects on peripheral tissues are observed. The proposed materials are suitable candidates for the use as resorbable tissue adhesives for meniscus repair.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Bochyńska AI,Hannink G,Rongen JJ,Grijpma DW,Buma Pdoi
10.1002/mabi.201700125subject
Has Abstractpub_date
2017-11-01 00:00:00issue
11eissn
1616-5187issn
1616-5195journal_volume
17pub_type
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