Abstract:
:Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to bone, cartilage, and skin TE. Current strategies in scaffold-guided TE approaches using polymers of natural origin and their composites are elaborated. Innovative modification techniques in creating functional materials for advanced TE applications are presented. Challenges and possible solutions in the technological innovation in factor molecules incorporation and surface functionalization for improving the fabrication of biomaterials scaffolds for cost-effective TE are also presented.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Khan F,Ahmad SRdoi
10.1002/mabi.201200409subject
Has Abstractpub_date
2013-04-01 00:00:00pages
395-421issue
4eissn
1616-5187issn
1616-5195journal_volume
13pub_type
杂志文章,评审abstract::The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, inclu...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600248
更新日期:2007-04-10 00:00:00
abstract::Biodegradable hydrogels were synthesized by the click reaction of 4-arm azido-terminated PEG differing in molecular weight (2,100 and 8,800) and two alkyne-terminated peptides: [alkyne]-GFLGK-[alkyne] and ([alkyne]-GFLG)(2)K. The physical properties of in situ formed hydrogels were examined. The hydrogels were highly ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900295
更新日期:2010-04-08 00:00:00
abstract::Bone loss through traumatic injury is a significant clinical issue. Researchers have created many scaffold types to mimic an extracellular matrix to provide structural support for the formation of new bone, however functional regeneration of larger scaffolds has not been fully achieved. Newer scaffolds aim to deliver ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000249
更新日期:2021-01-01 00:00:00
abstract::We report on a novel series of biomimetic polymers exhibiting interfacial properties similar to the extracellular matrix. A series of well-defined surfactant polymers were synthesized by simultaneously incorporating arginine-glycine-aspartic acid (RGD) peptide, dextran oligosaccharide, and hexyl ligands with controlle...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300125
更新日期:2004-08-09 00:00:00
abstract::An arginine-leucine block copolypeptide (R60 L20 ) is synthesized, which is capable of forming vesicles with controllable sizes, able to transport hydrophilic cargo across the cell membrane, and exhibit relatively low cytotoxicity. The R60 L20 vesicles also possess the ability to deliver DNA into mammalian cells for t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200383
更新日期:2013-05-01 00:00:00
abstract::Primary human megakaryocytes, the precursor cells of platelets, are difficult to collect and cultivate. Polymers that enrich these cells without affecting their regulation or function are of interest for basic research as well as for cord blood transplantation purposes since co-transplantation of enriched megakaryocyt...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200368
更新日期:2013-04-01 00:00:00
abstract::Novel temperature-sensitive poly(N-isopropylacrylamide)/amine-terminated polyamidoamine dendrimer G6-NH2 hydrogels with fast responsive properties were synthesized by forming semi-interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temp...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400003
更新日期:2004-06-25 00:00:00
abstract::Three types of multilayer films made from poly(L-lysine)/hyaluronan, chitosan/hyaluronan, and poly(allylamine hydrochloride)/poly(L-glutamic acid), were used to investigate the interplay between film mechano-chemical properties and cell adhesion. We showed that C2C12 myoblast adhesion and proliferation depended on the...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000301
更新日期:2011-01-10 00:00:00
abstract::Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800106
更新日期:2009-01-09 00:00:00
abstract::Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and r...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600105
更新日期:2016-11-01 00:00:00
abstract::An insoluble wheat proteins-based polymer networks with new functional groups and positive charges were prepared through grafting-coupling reactions. The networks were also flexible with a lower glass transition temperature since the existence of the grafted mobile segments. The multi-component/multi-phase systems bec...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800156
更新日期:2009-01-09 00:00:00
abstract::Solution-grown chain-folded lamellar single crystals of poly(tetramethylene adipate) (PTMA) were prepared from a dilute solution of 2-methyl-1-propanol by isothermal crystallization. PTMA crystals were hexagonal-shaped and polyethylene decoration of the crystals resulted in a "six cross-sector" surface morphology and ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300086
更新日期:2004-03-15 00:00:00
abstract::The effect of doping graphene oxide (GO) and reduced graphene oxide (rGO) into poly(ε-caprolactone) (PCL) membranes prepared by solvent induced phase separation is evaluated in terms of nanomaterial distribution and compatibility with neural stem cell growth and functional differentiation. Raman spectra analyses demon...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800195
更新日期:2018-11-01 00:00:00
abstract::Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, ce...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900090
更新日期:2019-07-01 00:00:00
abstract::In this study, GCC protein was used for the first time to construct a biodegradable conduit for peripheral nerve repair. The GCC was highly stable with a sufficiently high level of mechanical properties and it was non-toxic and non-apoptotic which could maintain the survival and outgrowth of Schwann cells. Noninvasive...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000498
更新日期:2011-07-07 00:00:00
abstract::A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400149
更新日期:2014-10-01 00:00:00
abstract::Uniform chitosan microspheres have been fabricated and weakly crosslinked for potential applications in colon-specific drug delivery. The effects of microsphere size, crosslinking density and electrostatic interactions between the drug and chitosan on drug release were studied, employing model drugs of different acidi...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800079
更新日期:2008-12-08 00:00:00
abstract::A simple continuous flow wet-spinning method to achieve mechanical reinforcement of the two oppositely charged biopolymers chitosan and gellan gum is described. The mechanical properties of these biopolymers are influenced by the order of addition. Using a facile method for mechanical reinforcement of gellan gum/chito...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800257
更新日期:2009-04-08 00:00:00
abstract::Two different composite scaffolds, solid-freeform-fabricated PCL/β-TCP supplemented with and without collagen nanofibers are fabricated. These scaffolds are evaluated whether a combination of collagen nanofibers with PCL/β-TCP can promote osteogenesis in a mastoid obliteration. To assess the effects of the cellular ac...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200393
更新日期:2013-05-01 00:00:00
abstract::The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000364
更新日期:2021-01-12 00:00:00
abstract::Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Micro...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200317
更新日期:2013-03-01 00:00:00
abstract::Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000186
更新日期:2020-10-01 00:00:00
abstract::To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500249
更新日期:2006-06-16 00:00:00
abstract::Two chondrogenic factors, Dex and TGF-beta1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-beta1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were s...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800187
更新日期:2009-03-10 00:00:00
abstract::Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA-Dex surface functionalized with a mucoadhesive ligand, PBA, were developed as drug carriers with particle sizes ranging from 25 to 28 nm. Using CycA as a model drug, we showed that ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200216
更新日期:2012-12-01 00:00:00
abstract::The aggregative behaviors of hydroxypropylcellulose (HPC) molecules in aqueous solution and on substrates have been observed by employing laser light scattering (LLS) and, after deposition on a mica surface, atomic force microscopy (AFM). LLS studies showed that the HPC molecules formed large aggregates through self-a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600067
更新日期:2006-07-14 00:00:00
abstract::Microbial transglutaminase (mTG) and mushroom tyrosinase (MT) are used to crosslink B. mori silk fibroin/gelatin (SF/G) films. Crosslinked and uncrosslinked SF/G films show no phase separation. The thermal behavior and the conformational structure of SF/G films are strongly affected by blending and enzymatic treatment...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300156
更新日期:2013-11-01 00:00:00
abstract::3D hydrogels better replicate in vivo conditions, and yield different results from 2D substrates. However, imaging interactions between cells and the hydrogel microenvironment is challenging because of light diffraction and poor focal depth. Here, cryosectioning and vibrating microtomy methods and fixation protocols a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600478
更新日期:2017-06-01 00:00:00
abstract::The use of glycopolymer-functionalized resins (Resin-Glc), as a solid support, in column mode for bacterial/protein capture and quantification is explored. The Resin-Glc is synthesized from commercially available chloromethylated polystyrene resin and glycopolymer, and is characterized by fourier transform infrared sp...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000342
更新日期:2020-12-18 00:00:00
abstract::A poly(o-methoxyaniline) (POMA)/DNA [weight fraction of DNA (W(DNA)) = 0.45] hybrid was prepared by mixing their solutions in sterilized double distilled water. The solution turned green upon aging for a longer time, and the doping of POMA by DNA was complete after about 15 d of aging. The doping was confirmed from th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400185
更新日期:2005-05-23 00:00:00