Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.

abstract：:The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacit...

journal_title：Macromolecular bioscience

authors： Dong X,Lin L,Chen J,Guo Z,Tian H,Li Y,Wei Y,Chen X

更新日期：2013-04-01 00:00:00

abstract：:Peptide dendrimers assembled by solid-phase peptide synthesis using a branching diamino acid at every 2(nd) or 3(rd) position provide readily accessible synthetic model systems for proteins and enzymes. They adopt a globular shape by topology rather than by folding. Peptide dendrimers of 2(nd) and 3(rd) generation fun...

journal_title：Macromolecular bioscience

authors： Delort E,Szöcs E,Widmer R,Siegenthaler H,Reymond JL

更新日期：2007-08-07 00:00:00

abstract：:A ternary complex comprising plasmid DNA, lipopolysaccharide-binding peptide (LBP), and deoxycholic acid-conjugated polyethylenimine (PEI-DA) is prepared for combinational therapy of acute lung injury (ALI). The LBP is designed as an anti-inflammatory peptide based on the lipopolysaccharide (LPS)-binding domain of HMG...

journal_title：Macromolecular bioscience

authors： Kim JY,Piao C,Kim G,Lee S,Lee MS,Jeong JH,Lee M

更新日期：2017-08-01 00:00:00

abstract：:Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...

journal_title：Macromolecular bioscience

authors： Jia X,Kiick KL

更新日期：2009-02-11 00:00:00

abstract：:Polycations, mimicking activity of antibacterial peptides, belong to an important class of molecules investigated as a support or as an alternative to antibiotics. In this work, studies of modified linear amphiphilic statistical polymethyloxazoline (PMOX) and polyethyleneimine copolymers (PMOX_PEI) series are presente...

journal_title：Macromolecular bioscience

authors： Kozon D,Mierzejewska J,Kobiela T,Grochowska A,Dudnyk K,Głogowska A,Sobiepanek A,Kuźmińska A,Ciach T,Augustynowicz-Kopeć E,Jańczewski D

更新日期：2019-12-01 00:00:00

abstract：:The present study describes the synthesis of novel polypeptides containing O-phospho-L-threonine [Thr(PO(3)H(2))] and L-aspartic acid. Random copolypeptides copoly[Thr(PO(3)H(2))(X)Asp(Y)] (X:Y = 25:75, 50:50, 75:25), were conventionally prepared by copolymerization of Thr(PO(3)Ph(2)) N-carboxyanhydride (NCA) and Asp(...

journal_title：Macromolecular bioscience

authors： Hayashi S,Ohkawa K,Yamamoto H

更新日期：2006-03-14 00:00:00

abstract：:The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new ...

journal_title：Macromolecular bioscience

authors： Houshyar S,Bhattacharyya A,Khalid A,Rifai A,Dekiwadia C,Kumar GS,Tran PA,Fox K

更新日期：2021-01-12 00:00:00

abstract：:In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

journal_title：Macromolecular bioscience

authors： Fan J,Li Y,Jiang H,Tang G,Wang L

更新日期：2008-05-13 00:00:00

abstract：:Three different microbial wild-type strains are compared with respect to their potential as industrial scale polyhydroxyalkanoate (PHA) producers from the feed stock whey lactose. The halophilic archaeon Haloferax mediterranei as well as two eubacterial strains (Pseudomonas hydrogenovora and Hydrogenophaga pseudoflava...

journal_title：Macromolecular bioscience

authors： Koller M,Hesse P,Bona R,Kutschera C,Atlić A,Braunegg G

更新日期：2007-02-12 00:00:00

abstract：:Bleeding complications usually cause significant morbidity and mortality in civilian and military populations. In clinical application, hemostatic sponges, gauzes, hydrogel, and bandages are widely used as the traditional effective hemostatic products for hemorrhage. However, the traditional hemostatic devices or agen...

journal_title：Macromolecular bioscience

authors： Chen Y,Wu L,Li P,Hao X,Yang X,Xi G,Liu W,Feng Y,He H,Shi C

更新日期：2020-04-01 00:00:00

abstract：:L-, P-, and E-Selectin are cell adhesion molecules that play a crucial role in leukocyte recruitment from the blood stream to the afflicted tissue in an acute and chronic inflammatory setting. Since selectins mediate the initial contact of leukocytes to the vascular endothelium, they have evolved as a valuable therape...

journal_title：Macromolecular bioscience

authors： Weinhart M,Gröger D,Enders S,Riese SB,Dernedde J,Kainthan RK,Brooks DE,Haag R

更新日期：2011-08-11 00:00:00

abstract：:Metastasis is a pathogenic spread of cancer cells from the primary site to surrounding tissues and distant organs, making it one of the primary challenges for effective cancer treatment and the major cause of cancer mortality. Heparin-based biomaterials exhibit significant inhibition of cancer cell metastasis. In this...

journal_title：Macromolecular bioscience

authors： Andrgie AT,Mekuria SL,Addisu KD,Hailemeskel BZ,Hsu WH,Tsai HC,Lai JY

更新日期：2019-05-01 00:00:00

abstract：:The fabrication of 3D cell microenvironments exploiting versatile, long-term stable passivating poly(acryl amide) brushes in a microwell format and the study of the behavior of fibroblast and pancreatic tumor cells in wells of systematically varied shape and size is reported. The microwells, which are obtained by comb...

journal_title：Macromolecular bioscience

authors： Lilge I,Jiang S,Schönherr H

更新日期：2017-05-01 00:00:00

abstract：:In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: I...

journal_title：Macromolecular bioscience

authors： Dimde M,Sahle FF,Wycisk V,Steinhilber D,Camacho LC,Licha K,Lademann J,Haag R

更新日期：2017-10-01 00:00:00

abstract：:Thermosensitive macroporous scaffolds of poly(N-isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin nanoparticles of 102 ± 6.5 nm diameter are prepared by complex coacervation and loaded into polyNIPA c...

journal_title：Macromolecular bioscience

authors： Peniche H,Reyes-Ortega F,Aguilar MR,Rodríguez G,Abradelo C,García-Fernández L,Peniche C,San Román J

更新日期：2013-11-01 00:00:00

abstract：:The properties of poly(D,L-lactide)-block-poly(2-hydroxyethyl acrylate) (PLA-b-PHEA) block copolymers by means of in vitro / in vivo (rat) degradation are investigated and compared to those of PLA homopolymer. Over 12 weeks, we observe mass loss and molecular weight decrease. In vitro and in vivo findings are very sim...

journal_title：Macromolecular bioscience

authors： Clément B,Decherchi P,Féron F,Bertin D,Gigmes D,Trimaille T,Marqueste T

更新日期：2011-09-09 00:00:00

abstract：:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

journal_title：Macromolecular bioscience

authors： Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

更新日期：2007-11-12 00:00:00

abstract：:The naturally occurring edible biopolymer poly(gamma-glutamic acid) (gamma-PGA) is shown to be an efficient chelating agent of vanadium(IV). The structure of poly(gamma-glutamic acid)oxovanadium(IV) (VO-gamma-PGA) complex in solution has been analyzed by electron spin resonance and UV-visible absorption spectra. The e...

journal_title：Macromolecular bioscience

authors： Karmaker S,Saha TK

更新日期：2008-02-11 00:00:00

abstract：:The immobilization of enzymes into polymer hydrogels is a versatile approach to improve their stability and utility in biotechnological and biomedical applications. However, these systems typically show limited enzyme activity, due to unfavorable pore dimensions and low enzyme accessibility. Here, 3D jet writing of wa...

journal_title：Macromolecular bioscience

authors： Steier A,Schmieg B,Irtel von Brenndorff Y,Meier M,Nirschl H,Franzreb M,Lahann J

更新日期：2020-09-01 00:00:00

abstract：:Numerous hydrogel-based culture systems are used to create in vitro model for prevascularization. Hydrogels used to induce a microenvironment conducive to microvessel formation are typically soft and fast degradable, but often suffer from maintaining a lasting perfusable channel in vitro. Here, a dual hydrogel system ...

journal_title：Macromolecular bioscience

authors： Kim S,Pan CC,Yang YP

更新日期：2020-10-01 00:00:00

abstract：:Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro releas...

journal_title：Macromolecular bioscience

authors： Ouimet MA,Fogaça R,Snyder SS,Sathaye S,Catalani LH,Pochan DJ,Uhrich KE

更新日期：2015-03-01 00:00:00

abstract：:Protein hydrophobic interaction has been considered the most important factor dominating protein folding, aggregation, gelling, self-assembly, adhesion, and cohesion properties. In this paper, morphology and phase separation of hydrophobic clusters, networks, and aggregates of soy globular protein polymers, induced by...

journal_title：Macromolecular bioscience

authors： Sun XS,Wang D,Zhang L,Mo X,Zhu L,Bolye D

更新日期：2008-04-09 00:00:00

abstract：:Protein-polymer conjugates are widely used to improve the pharmacokinetic properties of therapeutic proteins. Commercially available conjugates employ poly(ethylene glycol) (PEG) as the protective polymer; however, PEG has a number of shortcomings, including non-biodegradability and immunogenicity, that call for the d...

journal_title：Macromolecular bioscience

authors： Steinbach T,Becker G,Spiegel A,Figueiredo T,Russo D,Wurm FR

更新日期：2017-10-01 00:00:00

abstract：:Extraction processes of natural fibers can be performed by different procedures that include mechanical, chemical and biological methods. Each method presents different advantages or drawbacks according to the amount of fiber produced or the quality and properties of fiber bundles obtained. In this study, biological n...

journal_title：Macromolecular bioscience

authors： Gañán P,Zuluaga R,Velez JM,Mondragon I

更新日期：2004-10-20 00:00:00

abstract：:Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...

journal_title：Macromolecular bioscience

authors： Fukushima K,Furuhashi Y,Sogo K,Miura S,Kimura Y

更新日期：2005-01-14 00:00:00

abstract：:In this study, PLLA nanofibers are fabricated by electrospinning and their surfaces are modified by laminin/chitosan (LN/CS) polyelectrolyte multilayer. Surface C/N ratio determined by XPS analysis quantitatively indicates of discrete coating layers on the nanofibers. The amount of LN deposited sustainably increases w...

journal_title：Macromolecular bioscience

authors： He L,Tang S,Prabhakaran MP,Liao S,Tian L,Zhang Y,Xue W,Ramakrishna S

更新日期：2013-11-01 00:00:00

abstract：:Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl ...

journal_title：Macromolecular bioscience

authors： Koschella A,Inngjerdingen K,Paulsen BS,Morris GA,Harding SE,Heinze T

更新日期：2008-01-09 00:00:00

abstract：:In this study, GCC protein was used for the first time to construct a biodegradable conduit for peripheral nerve repair. The GCC was highly stable with a sufficiently high level of mechanical properties and it was non-toxic and non-apoptotic which could maintain the survival and outgrowth of Schwann cells. Noninvasive...

journal_title：Macromolecular bioscience

authors： Wang W,Lin JH,Tsai CC,Chuang HC,Ho CY,Yao CH,Chen YS

更新日期：2011-07-07 00:00:00

abstract：:The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

journal_title：Macromolecular bioscience

authors： Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

更新日期：2018-02-01 00:00:00

abstract：:BSA adsorption onto negatively and positively charged polystyrene nanoparticles was investigated. The nanoparticles were characterized in terms of particle size, zeta potential, surface group density, and morphology. The adsorption behavior of BSA on the particle surface, as a function of pH and overall charge of the ...

journal_title：Macromolecular bioscience

authors： Baier G,Costa C,Zeller A,Baumann D,Sayer C,Araujo PH,Mailänder V,Musyanovych A,Landfester K

更新日期：2011-05-12 00:00:00