Abstract:
:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased with the extension of the polymerization time, while the degradation rate decreased. Rat AF cells proliferated on the POM films and maintained their phenotype. The 3D scaffold also supported the growth of the AF cells, as confirmed by Safranin-O and type II collagen staining. POM also demonstrated a good biocompatibility in an in vivo foreign body response assay, an important prerequisite for tissue engineering applications. This study suggests that elastic POM scaffold may be an ideal candidate for AF tissue engineering.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li Xdoi
10.1002/mabi.200700053subject
Has Abstractpub_date
2007-11-12 00:00:00pages
1217-24issue
11eissn
1616-5187issn
1616-5195journal_volume
7pub_type
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