Reversible Bioconjugation: Biodegradable Poly(phosphate)-Protein Conjugates.

abstract：:Microbial transglutaminase (mTG) and mushroom tyrosinase (MT) are used to crosslink B. mori silk fibroin/gelatin (SF/G) films. Crosslinked and uncrosslinked SF/G films show no phase separation. The thermal behavior and the conformational structure of SF/G films are strongly affected by blending and enzymatic treatment...

journal_title：Macromolecular bioscience

authors： Taddei P,Chiono V,Anghileri A,Vozzi G,Freddi G,Ciardelli G

更新日期：2013-11-01 00:00:00

abstract：:HSVEC behavior under physiological shear stress in vitro is investigated on PET surfaces micropatterned with both RGDS and WQPPRARI peptides. This technique allows (i) creating geometries on surface to guide cell orientation under shear stress and (ii) controlling surface chemical composition in order to modulate cell...

journal_title：Macromolecular bioscience

authors： Chollet C,Bareille R,Rémy M,Guignandon A,Bordenave L,Laroche G,Durrieu MC

更新日期：2012-12-01 00:00:00

abstract：:In this paper we report on the synthesis of diversified linear polyamine architectures with different chain lengths and compositions and their interaction with phosphate groups of DNA/siRNA. The polyplex formation between model nucleotide (dsDNA) and these linear polyamines has been determined at different nitrogen to...

journal_title：Macromolecular bioscience

authors： Fischer W,Brissault B,Prévost S,Kopaczynska M,Andreou I,Janosch A,Gradzielski M,Haag R

更新日期：2010-09-09 00:00:00

abstract：:Stereolithography-assisted fabrication of hydrogels of carboxybetaine methacrylamide (CBMAA) and a α,ω-methacrylate poly(d,l-lactide-block-ethylene glycol-block- d,l-lactide) (MA-PDLLA-PEG-PDLLA-MA) telechelic triblock macromer is presented. This technique allows printing complex structures with gyroid interconnected ...

journal_title：Macromolecular bioscience

authors： Kostina NY,Blanquer S,Pop-Georgievski O,Rahimi K,Dittrich B,Höcherl A,Michálek J,Grijpma DW,Rodriguez-Emmenegger C

更新日期：2019-04-01 00:00:00

abstract：:In pluripotent stem cell differentiation, embryoid bodies (EBs) provide a three-dimensional [3D] multicellular precursor in lineage specification. The internal structure of EBs is not well characterized yet is predicted to be an important parameter to differentiation. Here, we use custom SU-8 molds to generate transpa...

journal_title：Macromolecular bioscience

authors： Tomov ML,Olmsted ZT,Paluh JL

更新日期：2015-07-01 00:00:00

abstract：:Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...

journal_title：Macromolecular bioscience

authors： Awada HK,Johnson NR,Wang Y

更新日期：2014-05-01 00:00:00

abstract：:Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...

journal_title：Macromolecular bioscience

authors： Cappitelli F,Zanardini E,Sorlini C

更新日期：2004-04-19 00:00:00

abstract：:Thermosensitive macroporous scaffolds of poly(N-isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin nanoparticles of 102 ± 6.5 nm diameter are prepared by complex coacervation and loaded into polyNIPA c...

journal_title：Macromolecular bioscience

authors： Peniche H,Reyes-Ortega F,Aguilar MR,Rodríguez G,Abradelo C,García-Fernández L,Peniche C,San Román J

更新日期：2013-11-01 00:00:00

abstract：:Polysaccharide hydrogels have found several applications in the food industry, in biomedicine, and cosmetics. The study of polysaccharide hydrogels offers a challenging scenario of intrinsic heterogeneities in the crosslinking density and large time and space ranges that characterize a number of dynamic processes enta...

journal_title：Macromolecular bioscience

authors： Cavalieri F,Chiessi E,Finelli I,Natali F,Paradossi G,Telling MF

更新日期：2006-08-07 00:00:00

abstract：:To explore the potential of a star-shaped 8-armed poly(ethylene glycol)35K-block-poly(L-lactide)37K (8-armed PEG35K-b-PLLA37K: M(n) of PEG = 35 000, M(n) of PLLA = 37 000) film as a novel bioabsorbable adhesion-prevention membrane, the water structure, surface contact angle, protein adsorption, and cell and platelet a...

journal_title：Macromolecular bioscience

authors： Nagahama K,Ohya Y,Ouchi T

更新日期：2006-06-16 00:00:00

abstract：:Mesenchymal stem cells (MSC), also called marrow stromal cells, are adult cells that have attracted interest for their potential uses in therapeutic applications. There is a pressing need for scalable culture systems due to the large number of cells needed for clinical treatments. Here, a tailorable thin polymer coati...

journal_title：Macromolecular bioscience

authors： Krutty JD,Dias AD,Yun J,Murphy WL,Gopalan P

更新日期：2019-02-01 00:00:00

abstract：:In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross-linking agent for chitosan (CS). This biocompatible material cross-links and gels in minutes. The structure and morphology were characterized by various analyses. The results indicate that t...

journal_title：Macromolecular bioscience

authors： Yu H,Lu J,Xiao C

更新日期：2007-09-11 00:00:00

abstract：:In the last decade, substantial research in the field of post-plasma grafting surface modification has focussed on the introduction of carboxylic acids on surfaces by grafting acrylic acid (AAc). In the present work, we report on an alternative approach for biomaterial surface functionalisation. Thin poly-ε-caprolacto...

journal_title：Macromolecular bioscience

authors： Desmet T,Billiet T,Berneel E,Cornelissen R,Schaubroeck D,Schacht E,Dubruel P

更新日期：2010-12-08 00:00:00

abstract：:In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymer...

journal_title：Macromolecular bioscience

authors： Fan J,Li Y,Jiang H,Tang G,Wang L

更新日期：2008-05-13 00:00:00

abstract：:Recently, the Foresight Institute has pronounced six economic challenges that can be addressed through the progress of nanotechnology. One of these is the health and longevity of human life. Amongst applications anticipated to provide a solution to this challenge, gene therapy appears to be particularly promising. In ...

journal_title：Macromolecular bioscience

authors： Lamarre B,Ryadnov MG

更新日期：2011-04-08 00:00:00

abstract：:Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and respons...

journal_title：Macromolecular bioscience

authors： Aksoy N,Akinci OF

更新日期：2004-05-17 00:00:00

abstract：:Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, ce...

journal_title：Macromolecular bioscience

authors： Dera R,Diliën H,Billen B,Gagliardi M,Rahimi N,Van Den Akker NMS,Molin DGM,Grandfils C,Adriaensens P,Guedens W,Cleij TJ

更新日期：2019-07-01 00:00:00

abstract：:The present study describes the synthesis of novel polypeptides containing O-phospho-L-threonine [Thr(PO(3)H(2))] and L-aspartic acid. Random copolypeptides copoly[Thr(PO(3)H(2))(X)Asp(Y)] (X:Y = 25:75, 50:50, 75:25), were conventionally prepared by copolymerization of Thr(PO(3)Ph(2)) N-carboxyanhydride (NCA) and Asp(...

journal_title：Macromolecular bioscience

authors： Hayashi S,Ohkawa K,Yamamoto H

更新日期：2006-03-14 00:00:00

abstract：:Uniform stereo-complex microparticles ranging from nanometer to micrometer size are prepared by using stereo multiblock co-poly(rac-lactide)s (smb-PLAs) with different stereo-regularity. At comparable molecular weights, as the smb-PLA stereo-regularity decreases from 88% to 76%, the crystallinity of the microparticles...

journal_title：Macromolecular bioscience

authors： Hu J,Tang Z,Qiu X,Han Y,Du Q,Chen X,Jing X

更新日期：2005-12-15 00:00:00

abstract：:In this study, GCC protein was used for the first time to construct a biodegradable conduit for peripheral nerve repair. The GCC was highly stable with a sufficiently high level of mechanical properties and it was non-toxic and non-apoptotic which could maintain the survival and outgrowth of Schwann cells. Noninvasive...

journal_title：Macromolecular bioscience

authors： Wang W,Lin JH,Tsai CC,Chuang HC,Ho CY,Yao CH,Chen YS

更新日期：2011-07-07 00:00:00

abstract：:Fluorescent dye labeled unfunctionalized and functionalized poly(n-butylcyanoacrylate) nanoparticles were prepared using a miniemulsion technique. Amino acid and methoxyPEG functionalization could be introduced by using aqueous solutions as an initiator for the anionic polymerization in the heterophase. All the partic...

journal_title：Macromolecular bioscience

authors： Weiss CK,Lorenz MR,Landfester K,Mailänder V

更新日期：2007-07-09 00:00:00

abstract：:Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrat...

journal_title：Macromolecular bioscience

authors： Jia X,Kiick KL

更新日期：2009-02-11 00:00:00

abstract：:An arginine-leucine block copolypeptide (R60 L20 ) is synthesized, which is capable of forming vesicles with controllable sizes, able to transport hydrophilic cargo across the cell membrane, and exhibit relatively low cytotoxicity. The R60 L20 vesicles also possess the ability to deliver DNA into mammalian cells for t...

journal_title：Macromolecular bioscience

authors： Sun VZ,Choe UJ,Rodriguez AR,Dai H,Deming TJ,Kamei DT

更新日期：2013-05-01 00:00:00

abstract：:3D hydrogels better replicate in vivo conditions, and yield different results from 2D substrates. However, imaging interactions between cells and the hydrogel microenvironment is challenging because of light diffraction and poor focal depth. Here, cryosectioning and vibrating microtomy methods and fixation protocols a...

journal_title：Macromolecular bioscience

authors： Short AR,Czeisler C,Stocker B,Cole S,Otero JJ,Winter JO

更新日期：2017-06-01 00:00:00

abstract：:The aim of this study is to design a novel two-component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin-based dermal scaffold more robust for the treatment of the clinically challenging pres...

journal_title：Macromolecular bioscience

authors： Sharma V,Kohli N,Moulding D,Afolabi H,Hook L,Mason C,García-Gareta E

更新日期：2017-11-01 00:00:00

abstract：:Novel temperature-sensitive poly(N-isopropylacrylamide)/amine-terminated polyamidoamine dendrimer G6-NH2 hydrogels with fast responsive properties were synthesized by forming semi-interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temp...

journal_title：Macromolecular bioscience

authors： Zhang JT,Huang SW,Zhuo RX

更新日期：2004-06-25 00:00:00

abstract：:The design of a novel polymer-modified overlayer composed of PPAPE and GPMS on a silicon wafer for immobilization of DNA molecules is described. After hydroxylation of Si(100) surfaces, GPMS molecules were self-assembled onto these surfaces. PPAPE molecules were then covalently attached to the epoxy-terminated surface...

journal_title：Macromolecular bioscience

authors： Demirel GB,Coşkun S,Kalkan M,Caykara T

更新日期：2009-05-13 00:00:00

abstract：:Although recently a growing number of reports demonstrate that topography or geometry of the substrate also plays an important role in the fate of the stem cells, most of these studies are usually completed by a few distinct patterns such as simple lines, posts, etc. As a result, there is a lack of quantitative analys...

journal_title：Macromolecular bioscience

authors： Seo CH,Furukawa K,Suzuki Y,Kasagi N,Ichiki T,Ushida T

更新日期：2011-07-07 00:00:00

abstract：:Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Theref...

journal_title：Macromolecular bioscience

authors： Greiner AM,Richter B,Bastmeyer M

更新日期：2012-10-01 00:00:00

abstract：:The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis a...

journal_title：Macromolecular bioscience

authors： Kim J,Kim KS,Park SJ,Na K

更新日期：2015-08-01 00:00:00