Cloning of poly(aspartic acid) (PAA) hydrolase-1 gene from Pedobacter sp. KP-2 and hydrolysis of thermally synthesized PAA by its gene product.

abstract：:Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...

journal_title：Macromolecular bioscience

authors： Prasad S,Achazi K,Schade B,Haag R,Sharma SK

更新日期：2018-07-01 00:00:00

abstract：:Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...

journal_title：Macromolecular bioscience

authors： Awada HK,Johnson NR,Wang Y

更新日期：2014-05-01 00:00:00

abstract：:A novel cell-supporting scaffold, Tetronic-oligolactide-heparin (TLH) hydrogel, was prepared by coupling heparin to polymerized Tetronic-oligolactide for use in improving tissue regeneration. Aqueous TLH solutions showed thermosensitive behavior, demonstrating potential for use as injectable hydrogels. The content and...

journal_title：Macromolecular bioscience

authors： Go DH,Joung YK,Lee SY,Lee MC,Park KD

更新日期：2008-12-08 00:00:00

abstract：:Mussel-inspired poly(dopamine) (PDA) coating is proven to be a simple, versatile, and effective strategy to promote cell adhesion onto various substrates. In this study, the initial adhesive behavior of human umbilical vein endothelial cells (HUVECs) is evaluated on a PDA coating under serum-free conditions. It is fou...

journal_title：Macromolecular bioscience

authors： Wang JL,Ren KF,Chang H,Jia F,Li BC,Ji Y,Ji J

更新日期：2013-04-01 00:00:00

abstract：:Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength ...

journal_title：Macromolecular bioscience

authors： Rajkhowa R,Gil ES,Kluge J,Numata K,Wang L,Wang X,Kaplan DL

更新日期：2010-06-11 00:00:00

abstract：:Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

journal_title：Macromolecular bioscience

authors： Ajiro H,Takahashi Y,Akashi M,Fujiwara T

更新日期：2012-10-01 00:00:00

abstract：:High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can b...

journal_title：Macromolecular bioscience

authors： Bat E,van Kooten TG,Feijen J,Grijpma DW

更新日期：2011-07-07 00:00:00

abstract：:Interaction of conjugated polymers with liposomes is an attractive approach that benefits from both systems' characteristics such as electroactivity and enhanced interaction with cells. Conjugated polymer-liposome complexes have been investigated for bioimaging, drug delivery, and photothermal therapy. Their fabricati...

journal_title：Macromolecular bioscience

authors： Eslami M,Zeglio E,Alosaimi G,Yan Y,Ruprai H,Macmillan A,Seidel J,Lauto A,Joukhdar H,Rnjak-Kovacina J,Mawad D

更新日期：2020-11-01 00:00:00

abstract：:Desferrioxamine (DFO) is a clinically approved, high affinity iron chelator used for the treatment of iron overload. Due to its short half-life and toxicity, DFO is administered for 8-12 h per day, 5-7 d per week. In this manuscript, the influence of molecular properties of hyperbranched polyglycerol (HPG)-DFO conjuga...

journal_title：Macromolecular bioscience

authors： Hamilton JL,Ul-Haq MI,Creagh AL,Haynes CA,Kizhakkedathu JN

更新日期：2017-03-01 00:00:00

abstract：:This study aims to develop an effective method to control motile microorganisms and enable their manipulation as functional 'live micro/nano robots'. A novel strategy based on Fe3 O4 nanoparticle-doped alginate hydrogel is developed to fashion an artificial extracellular matrix (ECM) for microbial cells (e.g., Sacchar...

journal_title：Macromolecular bioscience

authors： Shi X,Shi Z,Wang D,Ullah MW,Yang G

更新日期：2016-10-01 00:00:00

abstract：:Uniform chitosan microspheres have been fabricated and weakly crosslinked for potential applications in colon-specific drug delivery. The effects of microsphere size, crosslinking density and electrostatic interactions between the drug and chitosan on drug release were studied, employing model drugs of different acidi...

journal_title：Macromolecular bioscience

authors： Choy YB,Cheng F,Choi H,Kim KK

更新日期：2008-12-08 00:00:00

abstract：:Microparticle drug carriers made of biodegradable functional polyesters were produced. The polyesters consist of a poly(ε-caprolactone) backbone bearing pendant acryloyloxy and methacryloyloxy groups. Stable microparticles were prepared via an oil/water emulsion-solvent evaporation technique eventually combined with a...

journal_title：Macromolecular bioscience

authors： Vaida C,Mela P,Kunna K,Sternberg K,Keul H,Möller M

更新日期：2010-08-11 00:00:00

abstract：:Although chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western world, it remains incurable with conventional chemotherapeutic agents. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an antitumor candidate in cancer therapy. This study examines the proapoptotic effects...

journal_title：Macromolecular bioscience

authors： Franiak-Pietryga I,Ostrowska K,Maciejewski H,Appelhans D,Misiewicz M,Ziemba B,Bednarek M,Bryszewska M,Borowiec M

更新日期：2017-05-01 00:00:00

abstract：:Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inh...

journal_title：Macromolecular bioscience

authors： Chytil P,Koziolová E,Etrych T,Ulbrich K

更新日期：2018-01-01 00:00:00

abstract：:Plant derived flavonoids have not been well explored in tissue engineering applications due to difficulties in efficient formulations with biomaterials for controlled presentation. Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L-lactic acid) (P...

journal_title：Macromolecular bioscience

authors： Madhurakkat Perikamana SK,Lee SM,Lee J,Ahmad T,Lee MS,Yang HS,Shin H

更新日期：2019-04-01 00:00:00

abstract：:The material surface must be considered in the design of scaffolds for bone tissue engineering so that it supports bone cells adhesion, proliferation and differentiation. A biomimetic approach has been developed as a 3D surface modification technique to grow partially carbonated hydroxyapatite (the bonelike mineral) i...

journal_title：Macromolecular bioscience

authors： Zhang R,Ma PX

更新日期：2004-02-20 00:00:00

abstract：:Within this work, a new class of sequence-defined heteromultivalent glycomacromolecules bearing lactose residues and nonglycosidic motifs for probing glycoconjugate recognition in carbohydrate recognition domain (CRD) of galectin-3 is presented. Galectins, a family of β-galactoside-binding proteins, are known to play ...

journal_title：Macromolecular bioscience

authors： Freichel T,Heine V,Laaf D,Mackintosh EE,Sarafova S,Elling L,Snyder NL,Hartmann L

更新日期：2020-09-01 00:00:00

abstract：:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

journal_title：Macromolecular bioscience

authors： Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

更新日期：2007-11-12 00:00:00

abstract：:Uniform stereo-complex microparticles ranging from nanometer to micrometer size are prepared by using stereo multiblock co-poly(rac-lactide)s (smb-PLAs) with different stereo-regularity. At comparable molecular weights, as the smb-PLA stereo-regularity decreases from 88% to 76%, the crystallinity of the microparticles...

journal_title：Macromolecular bioscience

authors： Hu J,Tang Z,Qiu X,Han Y,Du Q,Chen X,Jing X

更新日期：2005-12-15 00:00:00

abstract：:L-, P-, and E-Selectin are cell adhesion molecules that play a crucial role in leukocyte recruitment from the blood stream to the afflicted tissue in an acute and chronic inflammatory setting. Since selectins mediate the initial contact of leukocytes to the vascular endothelium, they have evolved as a valuable therape...

journal_title：Macromolecular bioscience

authors： Weinhart M,Gröger D,Enders S,Riese SB,Dernedde J,Kainthan RK,Brooks DE,Haag R

更新日期：2011-08-11 00:00:00

abstract：:A nanoscale biodegradable polymersome with pH-tuning on-off membrane is prepared via the self-assembly of poly(β-amino ester)-based amphiphilic copolymers. The pH-sensitive polymersome-like vesicle structure includes two layers that can encapsulate either hydrophobic or hydrophilic therapeutic drugs at physiological p...

journal_title：Macromolecular bioscience

authors： Jeong IK,Gao GH,Li Y,Kang SW,Lee DS

更新日期：2013-07-01 00:00:00

abstract：:The present study describes the synthesis of novel polypeptides containing O-phospho-L-threonine [Thr(PO(3)H(2))] and L-aspartic acid. Random copolypeptides copoly[Thr(PO(3)H(2))(X)Asp(Y)] (X:Y = 25:75, 50:50, 75:25), were conventionally prepared by copolymerization of Thr(PO(3)Ph(2)) N-carboxyanhydride (NCA) and Asp(...

journal_title：Macromolecular bioscience

authors： Hayashi S,Ohkawa K,Yamamoto H

更新日期：2006-03-14 00:00:00

abstract：:Chronic non-healing wounds show delayed and incomplete healing processes and in turn expose patients to a high risk of infection. Treatment currently focuses on dressings that prevent microbial infiltration and keep a balanced moisture and gas exchange environment. Antibacterial delivery from dressings has existed for...

journal_title：Macromolecular bioscience

authors： Abrigo M,McArthur SL,Kingshott P

更新日期：2014-06-01 00:00:00

abstract：:The preparation of a novel peptide/dendrimer hybrid is reported in which an elastin-like oligopeptide is successfully assembled onto a poly(amidoamine) dendrimer surface (G4-ELP), and its unique thermo-responsive behavior is discussed. As a result, the G4-ELP is found to exhibit LCST behavior in the pH range 3-10 incl...

journal_title：Macromolecular bioscience

authors： Koga T,Iimura M,Higashi N

更新日期：2012-08-01 00:00:00

abstract：:The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanoco...

journal_title：Macromolecular bioscience

authors： Bannwarth MB,Ebert S,Lauck M,Ziener U,Tomcin S,Jakob G,Münnemann K,Mailänder V,Musyanovych A,Landfester K

更新日期：2014-09-01 00:00:00

abstract：:Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. In recent years, MB have also attracted interest as drug delivery systems. Soft-shelled lipidic MB tend to be more advantageous for US imaging, while hard-shelled polymeric MB appear to be more suitable for drug delivery purposes beca...

journal_title：Macromolecular bioscience

authors： Appold L,Shi Y,Rütten S,Kühne A,Pich A,Kiessling F,Lammers T

更新日期：2017-10-01 00:00:00

abstract：:Poly(vinyl alcohol)-pyrene-anti-metadherin (PVA-Py-(Anti-MTDH)), a novel antibody based water soluble probe containing both fluorescent and target sites in the structure for in vitro imaging of breast cancer cells is reported here. Since breast cancer cells have an excess of MDTH protein expressed on the surface, a PV...

journal_title：Macromolecular bioscience

authors： Medine EI,Odaci D,Gacal BN,Gacal B,Sakarya S,Unak P,Timur S,Yagci Y

更新日期：2010-06-11 00:00:00

abstract：:The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...

journal_title：Macromolecular bioscience

authors： Kaihara S,Osanai Y,Nishikawa K,Toshima K,Doi Y,Matsumura S

更新日期：2005-07-14 00:00:00

abstract：:The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

journal_title：Macromolecular bioscience

authors： Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

更新日期：2018-02-01 00:00:00

abstract：:A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create sin...

journal_title：Macromolecular bioscience

authors： Sun C,Jin X,Holzwarth JM,Liu X,Hu J,Gupte MJ,Zhao Y,Ma PX

更新日期：2012-06-01 00:00:00