Abstract:
:Microbial transglutaminase (mTG) and mushroom tyrosinase (MT) are used to crosslink B. mori silk fibroin/gelatin (SF/G) films. Crosslinked and uncrosslinked SF/G films show no phase separation. The thermal behavior and the conformational structure of SF/G films are strongly affected by blending and enzymatic treatment. Formation of high thermally stable crosslinked macromolecular species is observed, suggesting the occurrence of strong intermolecular interactions between the two polymers as confirmed by FT-Raman spectroscopy. Preliminary in vitro tests show that MT-crosslinked blends with G amounts ≥40% and mTG-crosslinked SF/G 60/40 films support C2C12 cardiomyocyte adhesion and proliferation.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Taddei P,Chiono V,Anghileri A,Vozzi G,Freddi G,Ciardelli Gdoi
10.1002/mabi.201300156subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1492-510issue
11eissn
1616-5187issn
1616-5195journal_volume
13pub_type
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