Transfection of mammalian cells using block copolypeptide vesicles.

abstract：:Local, micromechanical environment is known to influence cellular function in heterogeneous hydrogels, and knowledge gained in micromechanics will facilitate the improved design of biomaterials for tissue regeneration. In this study, a system comprising microstructured resilin-like polypeptide (RLP)-poly(ethylene glyc...

journal_title：Macromolecular bioscience

authors： Lau HK,Rattan S,Fu H,Garcia CG,Barber DM,Kiick KL,Crosby AJ

更新日期：2020-05-01 00:00:00

abstract：:In drug delivery to the human brain, blood vessels are a significant hurdle because they restrict the entry of most solutes to protect brain. To overcome this hurdle, an in vitro 3D model for brain endothelial barrier is developed using a microfluidic device with hydrogel providing a 3D extracellular matrix scaffold. ...

journal_title：Macromolecular bioscience

authors： Chung B,Kim J,Nam J,Kim H,Jeong Y,Liu HW,Cho Y,Kim YH,Oh HJ,Chung S

更新日期：2020-06-01 00:00:00

abstract：:Traditionally, conductive materials for electrodes are based on high modulus metals or alloys. Development of bioelectrodes that mimic the mechanical properties of the soft, low modulus tissues in which they are implanted is a rapidly expanding field of research. Many polymers exist that more closely match tissue mech...

journal_title：Macromolecular bioscience

authors： Patton AJ,Poole-Warren LA,Green RA

更新日期：2016-08-01 00:00:00

abstract：:The phase behavior of a water/hydroxypropyl cellulose/maleic acid-styrene copolymer (H2O/HPC/MAc-S) system was investigated in the semi-dilute range by turbidimetry, rheology, and optical microscopy. The two polymers under investigation form interpolymer complexes via hydrogen bonding. In the case of a total polymer c...

journal_title：Macromolecular bioscience

authors： Bumbu GG,Eckelt J,Wolf BA,Vasile C

更新日期：2005-10-20 00:00:00

abstract：:Interaction of conjugated polymers with liposomes is an attractive approach that benefits from both systems' characteristics such as electroactivity and enhanced interaction with cells. Conjugated polymer-liposome complexes have been investigated for bioimaging, drug delivery, and photothermal therapy. Their fabricati...

journal_title：Macromolecular bioscience

authors： Eslami M,Zeglio E,Alosaimi G,Yan Y,Ruprai H,Macmillan A,Seidel J,Lauto A,Joukhdar H,Rnjak-Kovacina J,Mawad D

更新日期：2020-11-01 00:00:00

abstract：:A novel cell-supporting scaffold, Tetronic-oligolactide-heparin (TLH) hydrogel, was prepared by coupling heparin to polymerized Tetronic-oligolactide for use in improving tissue regeneration. Aqueous TLH solutions showed thermosensitive behavior, demonstrating potential for use as injectable hydrogels. The content and...

journal_title：Macromolecular bioscience

authors： Go DH,Joung YK,Lee SY,Lee MC,Park KD

更新日期：2008-12-08 00:00:00

abstract：:Gliadin, a component of gluten and a known epitope, is implicated in celiac disease (CeD) and results in an inflammatory response in CeD patients when consumed. Acrylamide-based polyelectrolytes are employed as models to determine the effect of molecular weight and pendent group on non-covalent interaction modes with ...

journal_title：Macromolecular bioscience

authors： Bristol AN,Carpenter BP,Davis AN,Kemp LK,Rangachari V,Karim S,Morgan SE

更新日期：2020-08-01 00:00:00

abstract：:Microbial transglutaminase (mTG) and mushroom tyrosinase (MT) are used to crosslink B. mori silk fibroin/gelatin (SF/G) films. Crosslinked and uncrosslinked SF/G films show no phase separation. The thermal behavior and the conformational structure of SF/G films are strongly affected by blending and enzymatic treatment...

journal_title：Macromolecular bioscience

authors： Taddei P,Chiono V,Anghileri A,Vozzi G,Freddi G,Ciardelli G

更新日期：2013-11-01 00:00:00

abstract：:This study describes the development and cell culture application of nanometer thick photocrosslinkable thermoresponsive polymer films prepared by physical adsorption. Two thermoresponsive polymers, poly(N-isopropylacrylamide (NIPAm)-co-acrylamidebenzophenone (AcBzPh)) and poly(NIPAm-co-AcBzPh-co-N-tertbutylacrylamide...

journal_title：Macromolecular bioscience

authors： Healy D,Nash ME,Gorelov A,Thompson K,Dockery P,Beloshapkin S,Rochev Y

更新日期：2017-02-01 00:00:00

abstract：:The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacit...

journal_title：Macromolecular bioscience

authors： Dong X,Lin L,Chen J,Guo Z,Tian H,Li Y,Wei Y,Chen X

更新日期：2013-04-01 00:00:00

abstract：:BSA adsorption onto negatively and positively charged polystyrene nanoparticles was investigated. The nanoparticles were characterized in terms of particle size, zeta potential, surface group density, and morphology. The adsorption behavior of BSA on the particle surface, as a function of pH and overall charge of the ...

journal_title：Macromolecular bioscience

authors： Baier G,Costa C,Zeller A,Baumann D,Sayer C,Araujo PH,Mailänder V,Musyanovych A,Landfester K

更新日期：2011-05-12 00:00:00

abstract：:Injectable hydrogels are extensively used in drug delivery and tissue engineering to administer drugs, genes, growth factors and live cells. We report a method to produce tough, in-situ thermogelling, non-toxic, injectable hydrogels made of chitosan and hyaluronic acid co-crosslinked with β-glycerophophate and genipin...

journal_title：Macromolecular bioscience

authors： Jalani G,Rosenzweig DH,Makhoul G,Abdalla S,Cecere R,Vetrone F,Haglund L,Cerruti M

更新日期：2015-04-01 00:00:00

abstract：:The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...

journal_title：Macromolecular bioscience

authors： Kaihara S,Osanai Y,Nishikawa K,Toshima K,Doi Y,Matsumura S

更新日期：2005-07-14 00:00:00

abstract：:Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...

journal_title：Macromolecular bioscience

authors： Fukushima K,Furuhashi Y,Sogo K,Miura S,Kimura Y

更新日期：2005-01-14 00:00:00

abstract：:3D printing has become an essential part of bone tissue engineering and attracts great attention for the fabrication of bioactive scaffolds. Combining this rapid manufacturing technique with chemical precipitation, biodegradable 3D scaffold composed of polymer matrix (polylactic acid and polyethylene glycol), ceramics...

journal_title：Macromolecular bioscience

authors： Li X,Wang Y,Wang Z,Qi Y,Li L,Zhang P,Chen X,Huang Y

更新日期：2018-06-01 00:00:00

abstract：:The chain length and end groups of linear PEG grafted on smooth surfaces is known to influence protein adsorption and thrombocyte adhesion. Here, it is explored whether established structure function relationships can be transferred to application relevant, rough surfaces. Functionalization of poly(ether imide) (PEI) ...

journal_title：Macromolecular bioscience

authors： Neffe AT,von Ruesten-Lange M,Braune S,Luetzow K,Roch T,Richau K,Jung F,Lendlein A

更新日期：2013-12-01 00:00:00

abstract：:Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...

journal_title：Macromolecular bioscience

authors： Strzelczyk AK,Paul TJ,Schmidt S

更新日期：2020-10-01 00:00:00

abstract：:Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. In recent years, MB have also attracted interest as drug delivery systems. Soft-shelled lipidic MB tend to be more advantageous for US imaging, while hard-shelled polymeric MB appear to be more suitable for drug delivery purposes beca...

journal_title：Macromolecular bioscience

authors： Appold L,Shi Y,Rütten S,Kühne A,Pich A,Kiessling F,Lammers T

更新日期：2017-10-01 00:00:00

abstract：:The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis a...

journal_title：Macromolecular bioscience

authors： Kim J,Kim KS,Park SJ,Na K

更新日期：2015-08-01 00:00:00

abstract：:Although recently a growing number of reports demonstrate that topography or geometry of the substrate also plays an important role in the fate of the stem cells, most of these studies are usually completed by a few distinct patterns such as simple lines, posts, etc. As a result, there is a lack of quantitative analys...

journal_title：Macromolecular bioscience

authors： Seo CH,Furukawa K,Suzuki Y,Kasagi N,Ichiki T,Ushida T

更新日期：2011-07-07 00:00:00

abstract：:pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lip...

journal_title：Macromolecular bioscience

authors： Zheng C,Yao X,Qiu L

更新日期：2011-03-10 00:00:00

abstract：:Bioinks play a key role in determining the capability of the biofabricatoin processes and the resolution of the printed constructs. Excellent biocompatibility, tunable physical properties, and ease of chemical or biological modifications of gelatin methacryloyl (GelMA) have made it an attractive choice as bioinks for ...

journal_title：Macromolecular bioscience

authors： Kumar H,Sakthivel K,Mohamed MGA,Boras E,Shin SR,Kim K

更新日期：2021-01-01 00:00:00

abstract：:Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhes...

journal_title：Macromolecular bioscience

authors： Hsiong SX,Cooke PH,Kong HJ,Fishman ML,Ericsson M,Mooney DJ

更新日期：2008-06-11 00:00:00

abstract：:In the present study, a pH responsive dendritic polyglycerol nanogel (dPG-NG) is developed to measure the pH values inside the hair follicle (HF) using an ex vivo porcine ear model. The macromolecular precursors are labeled with a pH sensitive indodicarbocyanine dye (pH-IDCC) and a control dye (indocarbocyanine dye: I...

journal_title：Macromolecular bioscience

authors： Dimde M,Sahle FF,Wycisk V,Steinhilber D,Camacho LC,Licha K,Lademann J,Haag R

更新日期：2017-10-01 00:00:00

abstract：:Poly(N-methylvinylamines) with secondary amines can form complexes with plasmid DNA (pDNA) and provide transfection efficiency in HeLa cells in the same order as linear polyethyleneimine but with higher cell viability. Chemical modifications of poly(N-methylvinylamine) backbones are performed to further improve transf...

journal_title：Macromolecular bioscience

authors： Dréan M,Debuigne A,Jérôme C,Goncalves C,Midoux P,Rieger J,Guégan P

更新日期：2018-04-01 00:00:00

abstract：:The role viscoelasticity in fibrotic disease progression is an emerging area of interest. Here, a fast-relaxing hydrogel system is exploited to investigate potential crosstalk between calcium signaling and mechanotransduction. Poly(ethylene glycol) (PEG) hydrogels containing boronate and triazole crosslinkers are synt...

journal_title：Macromolecular bioscience

authors： Ma H,Macdougall LJ,GonzalezRodriguez A,Schroeder ME,Batan D,Weiss RM,Anseth KS

更新日期：2020-12-01 00:00:00

abstract：:Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...

journal_title：Macromolecular bioscience

authors： Ignatova M,Manolova N,Rashkov I

更新日期：2013-07-01 00:00:00

abstract：:A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

journal_title：Macromolecular bioscience

authors： Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

更新日期：2007-11-12 00:00:00

abstract：:The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to ...

journal_title：Macromolecular bioscience

authors： Albuquerque LJC,Alavarse AC,Carlan da Silva MC,Zilse MS,Barth MT,Bellettini IC,Giacomelli FC

更新日期：2018-02-01 00:00:00

abstract：:Considerable efforts have been devoted to enhancing the cell penetration of nanoparticles by coating cell-penetrating peptides (CPPs) on the surface. However, the internalization mechanism for a CPP at different concentrations varies a lot. It is acknowledged that the mechanism is restricted to endocytic pathway at re...

journal_title：Macromolecular bioscience

authors： Ming Y,Xiao Y,Tian Y,Zhou S

更新日期：2019-04-01 00:00:00