Vitamin Bc -Bearing Hydrophilic Photosensitizer Conjugate for Photodynamic Cancer Theranostics.

Abstract:

:The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis and photodynamic therapy of a tumor. The synthesized vitamin Bc -bearing hydrophilic photosensitizer conjugate has been characterized for the folic acid receptor expressing the ability to target tumor cells, which is facilitated by the chemical conjugation with folic acid. The vitamin Bc -bearing hydrophilic photosensitizer conjugate internalization mechanism was identified through a competitive inhibition test with free folic acid. We optimized the laser-sensitive, cytotoxicity changeable, vitamin Bc -bearing hydrophilic photosensitizer conjugate concentration, which is non-cytotoxic under normal conditions and specifically cytotoxic toward cancer cells (maximum 69.15%) under laser irradiation conditions used for theranostic agents. The cancer therapeutic and diagnosis effects of synthesized conjugate were confirmed in MDA-MB-231 cells and MDA-MB-231-bearing mice. As a result, the vitamin Bc -bearing hydrophilic photosensitizer conjugate exhibited a highly photodynamic therapeutic effect, which enabled the selective detection of a folic acid receptor expressing cancer using optical imaging.

journal_name

Macromol Biosci

authors

Kim J,Kim KS,Park SJ,Na K

doi

10.1002/mabi.201500060

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1081-90

issue

8

eissn

1616-5187

issn

1616-5195

journal_volume

15

pub_type

杂志文章
  • Polymersomes from polypeptide containing triblock Co- and terpolymers for drug delivery against pancreatic cancer: asymmetry of the external hydrophilic blocks.

    abstract::Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(γ-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two polymers exhibit similar PBLG(-d7) composition, while in the ABC, the volume fraction of PEO block is ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201400137

    authors: Iatrou H,Dimas K,Gkikas M,Tsimblouli C,Sofianopoulou S

    更新日期:2014-09-01 00:00:00

  • Synthesis of linear polyamines with different amine spacings and their ability to form dsDNA/siRNA complexes suitable for transfection.

    abstract::In this paper we report on the synthesis of diversified linear polyamine architectures with different chain lengths and compositions and their interaction with phosphate groups of DNA/siRNA. The polyplex formation between model nucleotide (dsDNA) and these linear polyamines has been determined at different nitrogen to...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000082

    authors: Fischer W,Brissault B,Prévost S,Kopaczynska M,Andreou I,Janosch A,Gradzielski M,Haag R

    更新日期:2010-09-09 00:00:00

  • A comparison of thiolated and disulfide-crosslinked polyethylenimine for nonviral gene delivery.

    abstract::Branched polyethylenimine (25 kDa) is thiolated and compared with redox-sensitive crosslinked derivatives. Both polymers thiol contents are assessed; the thiolated polymers have 390-2300 mmol SH groups/mol, whereas the crosslinked polymers have lower thiol contents. Cytotoxicity assays show that both modified polymers...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201300103

    authors: Aravindan L,Bicknell KA,Brooks G,Khutoryanskiy VV,Williams AC

    更新日期:2013-09-01 00:00:00

  • Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration.

    abstract::Injectable delivery systems have been widely used in tissue engineering as they can deliver cells into the body in a minimally invasive manner. In this study, it is hypothesized that microspheres with a similar size of cells could effectively form a shear reversible aggregate in the presence of cells and the aggregate...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201300365

    authors: Woo E,Park H,Lee KY

    更新日期:2014-05-01 00:00:00

  • Random and sequential copolypeptides containing O-phospho-L-threonine and L-aspartic acid; roles in CaCO3 biomineralization.

    abstract::The present study describes the synthesis of novel polypeptides containing O-phospho-L-threonine [Thr(PO(3)H(2))] and L-aspartic acid. Random copolypeptides copoly[Thr(PO(3)H(2))(X)Asp(Y)] (X:Y = 25:75, 50:50, 75:25), were conventionally prepared by copolymerization of Thr(PO(3)Ph(2)) N-carboxyanhydride (NCA) and Asp(...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200500211

    authors: Hayashi S,Ohkawa K,Yamamoto H

    更新日期:2006-03-14 00:00:00

  • Development, Validation, and Performance of Chitosan-Based Coatings Using Catechol Coupling.

    abstract::The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201900253

    authors: Souza Campelo C,Chevallier P,Loy C,Silveira Vieira R,Mantovani D

    更新日期:2020-01-01 00:00:00

  • Formation of wheat-protein-based biomaterials through polymer grafting and crosslinking reactions to introduce new functional properties.

    abstract::An insoluble wheat proteins-based polymer networks with new functional groups and positive charges were prepared through grafting-coupling reactions. The networks were also flexible with a lower glass transition temperature since the existence of the grafted mobile segments. The multi-component/multi-phase systems bec...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200800156

    authors: Kurniawan L,Qiao GG,Zhang X

    更新日期:2009-01-09 00:00:00

  • Merging organic and polymer chemistries to create glycomaterials for glycomics applications.

    abstract::[Image: see text] Oligosaccharides at cell surfaces are known to play a critical role in many biological processes such as biorecognition, interactions between cells and with artificial surfaces, immune response, infection and inflammation. In order to facilitate studies of the role of sugars, an increasing number of ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200600090

    authors: Coullerez G,Seeberger PH,Textor M

    更新日期:2006-08-07 00:00:00

  • Galactose-functionalized gelatin hydrogels improve the functionality of encapsulated HepG2 cells.

    abstract::The present study investigates the effect of galactosylated gelatin on encapsulated HepG2 cells. Methacrylamide modified gelatin is evaluated and compared with its galactosylated counterpart with respect to effects on viability, morphological characteristics, proliferation, and the expression of hepatocyte specific ma...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201300320

    authors: Gevaert E,Billiet T,Declercq H,Dubruel P,Cornelissen R

    更新日期:2014-03-01 00:00:00

  • Morphology and phase separation of hydrophobic clusters of soy globular protein polymers.

    abstract::Protein hydrophobic interaction has been considered the most important factor dominating protein folding, aggregation, gelling, self-assembly, adhesion, and cohesion properties. In this paper, morphology and phase separation of hydrophobic clusters, networks, and aggregates of soy globular protein polymers, induced by...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200700235

    authors: Sun XS,Wang D,Zhang L,Mo X,Zhu L,Bolye D

    更新日期:2008-04-09 00:00:00

  • Direct biomolecule binding on nonfouling surfaces via newly discovered supramolecular self-assembly of lysozyme under physiological conditions.

    abstract::When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and q...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200092

    authors: Yang P

    更新日期:2012-08-01 00:00:00

  • Self-assembling viral mimetics: one long journey with short steps.

    abstract::Recently, the Foresight Institute has pronounced six economic challenges that can be addressed through the progress of nanotechnology. One of these is the health and longevity of human life. Amongst applications anticipated to provide a solution to this challenge, gene therapy appears to be particularly promising. In ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.201000330

    authors: Lamarre B,Ryadnov MG

    更新日期:2011-04-08 00:00:00

  • Facile synthesis and structural characterization of amylose-Fatty Acid inclusion complexes.

    abstract::Amylose-fatty acid inclusion complexes can be easily prepared by simple mixing in hot aqueous solutions. Above a critical chain length (C6) of the fatty acid insoluble complexes between amylose and each fatty acid (C8, C10, C12, C14, C16) were precipitated from the solution, and characterized by FT-IR, XRD, DSC, and S...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201400464

    authors: Cao Z,Woortman AJ,Rudolf P,Loos K

    更新日期:2015-05-01 00:00:00

  • Collagen-polymer guidance of vessel network formation and stabilization by endothelial colony forming cells in vitro.

    abstract::Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial c...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201300128

    authors: Whittington CF,Yoder MC,Voytik-Harbin SL

    更新日期:2013-09-01 00:00:00

  • Polymers for the cell-specific immobilisation of megakaryocytic cell lines.

    abstract::Primary human megakaryocytes, the precursor cells of platelets, are difficult to collect and cultivate. Polymers that enrich these cells without affecting their regulation or function are of interest for basic research as well as for cord blood transplantation purposes since co-transplantation of enriched megakaryocyt...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200368

    authors: Hansen A,Corless S,Cleland A,Petrik J,Gilbert N,Bradley M

    更新日期:2013-04-01 00:00:00

  • Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration.

    abstract::A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased wi...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200700053

    authors: Wan Y,Feng G,Shen FH,Balian G,Laurencin CT,Li X

    更新日期:2007-11-12 00:00:00

  • The biodeterioration of synthetic resins used in conservation.

    abstract::Synthetic resins have been extensively employed by artists in their works of art, e.g. as paint binders, or by conservators for conservation treatments, e.g. as stone consolidants and protectives. It is generally thought that synthetic resins are less prone to chemical, physical and biological deterioration than other...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.200300055

    authors: Cappitelli F,Zanardini E,Sorlini C

    更新日期:2004-04-19 00:00:00

  • Transfection of mammalian cells using block copolypeptide vesicles.

    abstract::An arginine-leucine block copolypeptide (R60 L20 ) is synthesized, which is capable of forming vesicles with controllable sizes, able to transport hydrophilic cargo across the cell membrane, and exhibit relatively low cytotoxicity. The R60 L20 vesicles also possess the ability to deliver DNA into mammalian cells for t...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200383

    authors: Sun VZ,Choe UJ,Rodriguez AR,Dai H,Deming TJ,Kamei DT

    更新日期:2013-05-01 00:00:00

  • DNA polyplexes formed using PEGylated biodegradable hyperbranched polymers.

    abstract::A novel PEGylated biodegradable hyperbranched PEG-b-PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide-based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.200900378

    authors: Tao L,Chou WC,Tan BH,Davis TP

    更新日期:2010-06-11 00:00:00

  • A topographically optimized substrate with well-ordered lattice micropatterns for enhancing the osteogenic differentiation of murine mesenchymal stem cells.

    abstract::Although recently a growing number of reports demonstrate that topography or geometry of the substrate also plays an important role in the fate of the stem cells, most of these studies are usually completed by a few distinct patterns such as simple lines, posts, etc. As a result, there is a lack of quantitative analys...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000477

    authors: Seo CH,Furukawa K,Suzuki Y,Kasagi N,Ichiki T,Ushida T

    更新日期:2011-07-07 00:00:00

  • Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH.

    abstract::The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine and phenylalanine peptide synthons allow the assembly/disassembly to be adjusted in a physiologically relevant range of pH 5.3-6.0. Co...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700111

    authors: Ahlers P,Frisch H,Holm R,Spitzer D,Barz M,Besenius P

    更新日期:2017-10-01 00:00:00

  • Degradable polyesters through chain linking for packaging and biomedical applications.

    abstract::The major route to convert lactic acid to high-molecular-weight polymers is ring-opening polymerization of lactide. We have investigated alternative synthesis routes based on oligomerization and chain linking to produce high-molecular-weight thermoplastic degradable polymers cost-effectively. Chain linking also offers...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章,评审

    doi:10.1002/mabi.200300105

    authors: Seppälä JV,Helminen AO,Korhonen H

    更新日期:2004-03-15 00:00:00

  • A Novel Small-Caliber Bacterial Cellulose Vascular Prosthesis: Production, Characterization, and Preliminary In Vivo Testing.

    abstract::Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose (BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall p...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201500251

    authors: Leitão AF,Faria MA,Faustino AM,Moreira R,Mela P,Loureiro L,Silva I,Gama M

    更新日期:2016-01-01 00:00:00

  • Hybrid polyglycerols with long blood circulation: synthesis, biocompatibility, and biodistribution.

    abstract::Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and bra...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201400152

    authors: Imran ul-haq M,Lai BF,Kizhakkedathu JN

    更新日期:2014-10-01 00:00:00

  • Characterization of Hydrogels Made of a Novel Spider Silk Protein eMaSp1s and Evaluation for 3D Printing.

    abstract::Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into sc...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700141

    authors: Thamm C,DeSimone E,Scheibel T

    更新日期:2017-11-01 00:00:00

  • Enhanced efficacy of pluronic copolymer micelle encapsulated SCR7 against cancer cell proliferation.

    abstract::5,6-Bis(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside the cells. In spite of the promising potential as an anticancer agent, hydrophobicity of SC...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201400480

    authors: John F,George J,Vartak SV,Srivastava M,Hassan PA,Aswal VK,Karki SS,Raghavan SC

    更新日期:2015-04-01 00:00:00

  • Polylactide block copolymers using trimethylene carbonate with methoxyethoxy side groups for dual modification of hydrophilicity and biodegradability.

    abstract::Novel block copolymers using the monomers 5-(2-methoxyethyoxymethyl)-5-methyl-[1,3]-dioxa-2-one (TMCM-MOE1OM) as a hydrophilic segment and lactides as a hydrophobic segment were designed in order to prepare controllable degradation polymers by dynamic polymer rearrangement based on the hydrophilicity. When the copolym...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201200143

    authors: Ajiro H,Takahashi Y,Akashi M,Fujiwara T

    更新日期:2012-10-01 00:00:00

  • Construction of a hyperbranched supramolecular polymer as a bifunctional antioxidative enzyme model.

    abstract::A HBSP has been designed as a novel bifunctional enzyme model with SOD and GPx activity by host/guest-directed self-assembly of MnTPyP-M-Ad and 6-Te-diCD. The structure of the host/guest complex was elucidated by (1) H NMR spectra, and the HBSP was characterized by SEM, DLS and measurement of catalytic properties. In ...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201000478

    authors: Yu S,Zhang W,Zhu J,Yin Y,Jin H,Zhou L,Luo Q,Xu J,Liu J

    更新日期:2011-06-14 00:00:00

  • Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles.

    abstract::Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential veh...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700200

    authors: Borke T,Najberg M,Ilina P,Bhattacharya M,Urtti A,Tenhu H,Hietala S

    更新日期:2018-01-01 00:00:00

  • Design of a Novel Two-Component Hybrid Dermal Scaffold for the Treatment of Pressure Sores.

    abstract::The aim of this study is to design a novel two-component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin-based dermal scaffold more robust for the treatment of the clinically challenging pres...

    journal_title:Macromolecular bioscience

    pub_type: 杂志文章

    doi:10.1002/mabi.201700185

    authors: Sharma V,Kohli N,Moulding D,Afolabi H,Hook L,Mason C,García-Gareta E

    更新日期:2017-11-01 00:00:00