Abstract:
:We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce cell adhesion. By comparing the film chemistries at the "critical" conditions, we demonstrate the dominant role of primary amines in the cell adhesion mechanism. Quantitative real-time RT-PCR experiments using U937 cells that had adhered to PVP:N materials for up to 24 h are presented. The adhesion induces a transient expression of cytokines, markers of macrophage activation, as well as a more sustained expression of PPAR gamma and ICAM-I.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Girard-Lauriault PL,Truica-Marasescu F,Petit A,Wang HT,Desjardins P,Antoniou J,Mwale F,Wertheimer MRdoi
10.1002/mabi.200800359subject
Has Abstractpub_date
2009-09-09 00:00:00pages
911-21issue
9eissn
1616-5187issn
1616-5195journal_volume
9pub_type
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